The distribution of labelled aminotriazole in mice

Autoradiographic and biochemical studies of drug distribution in the liver III. [14C] Aminotriazole

“…For the third case, the distribution pattern of certain radioactive compounds in the liver (5,6) changes from a homogeneous to heterogeneous one, which is in problem in the present paper.…”

Autoradiographic and biochemical studies of drug distribution in the liver III. [14C] Aminotriazole

“…For the third case, the distribution pattern of certain radioactive compounds in the liver (5,6) changes from a homogeneous to heterogeneous one, which is in problem in the present paper.…”

Autoradiographic and biochemical studies of drug distribution in the liver I. [14C] Dehydrocorydaline

“…Heterogeneous -distribution pattern of radioactive compounds in the liver has been reported in some macroautoradiography investigations with various expression such as spotted (10), uneven (12), mottled (29) and others (7,8). However, neither its histological features nor its cause has been studied.…”

“…Such heterogeneous distribution pattern in the liver has been occasionally observed by autoradiography for labeled chloropromazine (5), irnipraSend reprint requests to: T. Fujii, Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Enoki 33-94, Suita, Osaka, 564 Japan. mine (6), aminotriazole (7), chloroform (8), hexachlorobinephyl (9) and others (10)(11)(12)(13)(14). The pattern is rather rare since, in general, radioactive compounds are distributed relatively evenly in the liver.…”

Autoradiographic and biochemical studies of drug distribution in the liver II. [35S] chlorpromazine and [14C] imipramine

“…The cellular radioactivity was then gradually decreased, which may imply that active elimination of unchanged drug or biotransformation might occur since the decrease was not seen when cells were incubated at 0-5°C (data not cited). Despite the decrease, however, their cellular levels were [3][4] times as high as those of ['4C]salicylic acid whose distribution pattern in the liver is homogeneous in the macroautoradiography (17). …”

Autoradiographic and biochemical studies of drug distribution in the liver III. [14C] Aminotriazole

“…For the third case, the distribution pattern of certain radioactive compounds in the liver (5,6) changes from a homogeneous to heterogeneous one, which is in problem in the present paper.…”

Autoradiographic and biochemical studies of drug distribution in the liver I. [14C] Dehydrocorydaline

“…Heterogeneous -distribution pattern of radioactive compounds in the liver has been reported in some macroautoradiography investigations with various expression such as spotted (10), uneven (12), mottled (29) and others (7,8). However, neither its histological features nor its cause has been studied.…”

“…Such heterogeneous distribution pattern in the liver has been occasionally observed by autoradiography for labeled chloropromazine (5), irnipraSend reprint requests to: T. Fujii, Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Enoki 33-94, Suita, Osaka, 564 Japan. mine (6), aminotriazole (7), chloroform (8), hexachlorobinephyl (9) and others (10)(11)(12)(13)(14). The pattern is rather rare since, in general, radioactive compounds are distributed relatively evenly in the liver.…”

Autoradiographic and biochemical studies of drug distribution in the liver II. [35S] chlorpromazine and [14C] imipramine

“…The cellular radioactivity was then gradually decreased, which may imply that active elimination of unchanged drug or biotransformation might occur since the decrease was not seen when cells were incubated at 0-5°C (data not cited). Despite the decrease, however, their cellular levels were [3][4] times as high as those of ['4C]salicylic acid whose distribution pattern in the liver is homogeneous in the macroautoradiography (17). …”

Autoradiographic and biochemical studies of drug distribution in the liver III. [14C] Aminotriazole

“…For the third case, the distribution pattern of certain radioactive compounds in the liver (5,6) changes from a homogeneous to heterogeneous one, which is in problem in the present paper.…”

Autoradiographic and biochemical studies of drug distribution in the liver I. [14C] Dehydrocorydaline

“…Heterogeneous -distribution pattern of radioactive compounds in the liver has been reported in some macroautoradiography investigations with various expression such as spotted (10), uneven (12), mottled (29) and others (7,8). However, neither its histological features nor its cause has been studied.…”

“…Such heterogeneous distribution pattern in the liver has been occasionally observed by autoradiography for labeled chloropromazine (5), irnipraSend reprint requests to: T. Fujii, Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Enoki 33-94, Suita, Osaka, 564 Japan. mine (6), aminotriazole (7), chloroform (8), hexachlorobinephyl (9) and others (10)(11)(12)(13)(14). The pattern is rather rare since, in general, radioactive compounds are distributed relatively evenly in the liver.…”

Autoradiographic and biochemical studies of drug distribution in the liver II. [35S] chlorpromazine and [14C] imipramine

“…The cellular radioactivity was then gradually decreased, which may imply that active elimination of unchanged drug or biotransformation might occur since the decrease was not seen when cells were incubated at 0-5°C (data not cited). Despite the decrease, however, their cellular levels were [3][4] times as high as those of ['4C]salicylic acid whose distribution pattern in the liver is homogeneous in the macroautoradiography (17). …”