The diagnostic and prognostic value of biomarkers in women with coronary artery disease and osteoporosis

Abstract

Valeur diagnostique et pronostique des biomarqueurs chez les femmes atteintes de maladie coronarienne et d'ostéoporose Introduction. Depuis le début de la ménopause chez la population féminine, l'incidence des pathologies cardiovasculaires et les modifications de la densité minérale osseuse (DMO) ont considérablement augmenté Le but de l'étude. Étudier la valeur diagnostique et pronostique des biomarqueurs du remodelage osseux et vasculaire en déterminant leur relation avec les facteurs de progression de la maladie coronarienne en combinaison avec l'ostéoporose post-ménopause (PMOS). Matériels et méthodes. L'étude comprenait 115 femmes ménopausées chez lesquelles on avait diagnostiqué une maladie coronarienne. En fonction de l'état de la DMO, les patientes sont divisées en trois groupes: (1) avec une DMO normale, (2) avec une ostéopénie, (3) avec une ostéoporose. Le groupe de contrôle était ABSTRACT Introduction. Since the onset of menopause, the incidence of cardiovascular pathology and changes in bone mineral density (BMD) in the female population significantly increase. The objective of the study. To determine the diagnostic and prognostic value of bone and cardiovascular remodeling biomarkers in terms of determining their interrelationship with coronary artery disease (CAD) progression on the background of postmenopausal osteoporosis (PMOS). Material and methods. The study involved 115 women in the postmenopausal period, with a diagnosis of CAD. Depending on the BMD state, patients were divided into three groups: (1)-with normal BMD, (2)with osteopenia, (3)-with osteoporosis. The selected control group consisted of 12 relatively healthy women of the corresponding age. Daily monitoring of electrocardiogram by Holter, two-dimensional echocardiography, intima-media thickness (IMT) measurement, the

The Role of Lyophilized Xenodermotransplants in Repairing the Atria’s Structure and the Peculiarities of Regenerative Processes after Thermal Trauma in an Experiment

“…Exogenous and endogenous intoxication is a significant contributor to the changes observed in the myocardium following severe burns. Burn wounds are a common source of such intoxication, and consequently, reducing toxin levels in the body represents a promising avenue for treatment [8][9][10][11]. One area of recent interest in wound treatments is the development and application of biologically active dressings that can release substances that aid in reparative processes.…”

“…These changes are often caused by the exogenous and endogenous intoxication of the body, with burn wounds being a frequent source. Therefore, the use of tools to reduce the level of toxins in the body is promising for the treatment of severe burns [8][9][10][11]. In recent years, Life 2023, 13, 1470 2 of 13 lyophilized xenodermografts have increasingly been used in combustiology to temporarily close wound surfaces and repair biological membranes [12].…”

Vegetative and electrical disorders in women with chronic coronary syndrome depending on the state of bone mineral density

“…The BMD state was assessed with the help of the ultrasound osteodensitometry on the Omnisense 7000 apparatus (Israel) according to the criteria specified in our previous works [13][14][15]. Electrical and ischemic parameters were investigated using Holter ECG daily moni toring with the use of a Cardiosens K instrument (KhAI MEDICA, Ukraine) according to the recommendations of the European Society of Cardiologists, and the Ukrainian Association of Cardiologists.…”