The diagnostic and clinicopathological value of trefoil factor 3 in patients with gastric cancer: a systematic review and meta-analysis

Zhang, Chenxing; Wu, Chutian; Xiao, Lin; Tang, Shaohui

doi:10.1080/1354750x.2020.1871411

“…Accelerated dynamic acquisition enhanced scan of gastric volume, slice thickness 5 mm, and slice interval 1 mm. The patient was given an intravenous injection of 1.5 ml/s of 15 ml of meglumine spray, and all data were input to the ADW4.5 processing station for high-density and multiplanar projection imaging [ 2 , 16 ]. The patient was scanned with a GE Lightspeed QX/ICT scanner, the tube voltage was 120 kV, the tube current was adjusted according to the actual situation of the test (250~300 mA), the layer thickness was 1.0 mm, the pitch was 3, and the scanning time was 8 ~ 10 s. Half an hour before the multispiral CT scan, 20 mg of intramuscular anisodamine hydrochloride muscles prevents the normal peristalsis of the gastrointestinal tract, and none of the patients had the stomach inflated through a gastric tube.…”

Section: Methodsmentioning

confidence: 99%

“…When the patient has onset, the early symptoms are not obvious, some patients are often accompanied by nausea, belching, abdominal discomfort, and other symptoms, and serious complications such as pathological tissue changes, upper gastrointestinal symptoms, melena, perforation of tumor ulcers, and jaundice may occur in patients with advanced disease. To this end, it should be detected and treated early [ 2 ]. The direction of preoperative evaluation of gastric cancer mainly includes lymph node metastasis and tumor invasion depth.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of Spiral CT and Magnetic Resonance Imaging Scanning in Gastric Cancer and Precancerous Lesions

Zhen

¹

,

Xie

²

,

Liu

³

2022

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In order to explore the diagnostic value of spiral CT and magnetic resonance imaging scanning in gastric cancer and precancerous lesions, the author selected 56 gastric cancer patients treated in a medical center (group) as the experimental subjects, and all patients underwent MRI, multislice spiral CT scan, and enhanced CT scan two weeks before surgery; at the same time, the gastric cancer staging results of patients were diagnosed according to surgical pathology. All patients were examined under the condition of knowledge and performed breath-holding exercise before examination. The status, location, and extent of tumor lesions were evaluated. In comparison of T staging of gastric cancer patients with magnetic resonance scanning imaging and postoperative pathological examination results, among them, T staging of 3 patients did not match the results of pathological examination, the accuracy rates of T staging on magnetic resonance scanning imaging were T 1 = 94.7 % , T 2 = 87.6 % , T 3 = 91.2 % , and T 4 = 94.7 % , and the total accuracy was 92.1%. Comparison of helical CT scan imaging and postoperative pathological examination results is as follows. Among them, T staging of 8 patients did not match the results of pathological examination, 3 patients were ulcerative, 5 were protuberance, the accuracy rates of T staging in spiral CT scan imaging were T 1 = 90.8 % , T 2 = 82.2 % , T 3 = 76.9 % , and T 4 = 87.6 % , and the total accuracy was 84.5%. The total accuracy rate of imaging N staging was 77.5%, and the total accuracy rate of spiral CT scanning imaging N staging was 80.8%. The accuracy rates of M0 and M1 staging in magnetic resonance imaging were 100.0% and 96.5%, respectively, and the accuracy rates of M0 and M1 staging in spiral CT scan imaging were 96.5% and 96.5%, respectively. The accuracy rate of magnetic resonance imaging for the diagnosis of gastric cancer N staging was 77.4%, and the reason for the low accuracy rate was mainly because the enhancement effect was not obvious due to insufficient enhancement. The accuracy rate of spiral CT in diagnosing N staging of gastric cancer was 80.9%, which was mainly due to the small diameter of the middle celiac artery lymph nodes. Magnetic resonance and spiral CT scans have high value in the early diagnosis and staging of gastric cancer.

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“…Moreover, a deep learning computed tomography (CT) signature was developed to predict the prognosis and benefit from adjuvant chemotherapy in gastric cancer [ 61 ]. Many single biomarkers such as MTA1 [ 62 ], TFF3 [ 63 ], and CA72-4 [ 64 ] were also reported to be related to the prognosis of gastric cancer with systemic therapy. As a simple and feasible biomarker, NLR is easily obtained from the regular blood tests, which highlights its practicability in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Pretreatment neutrophil-to-lymphocyte ratio predicts the benefit of gastric cancer patients with systemic therapy

Du

¹

,

Fang

²

,

Lin

³

et al. 2021

Aging

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Pretreatment neutrophil-to-lymphocyte ratio (NLR) has been reported to be associated with the prognosis of inoperable gastric cancer patients with systemic therapy. However, no consensus on the association has been reached. In this study, we mainly evaluated whether pretreatment NLR predicted the benefit of inoperable gastric cancer patients with systemic therapy, including chemotherapy, targeted therapy and immunotherapy. PubMed, Embase and Cochrane Library databases were systematically searched from inception up to September 16th, 2020. A total of 36 studies including 8614 patients were involved in the meta-analysis. Pooled data revealed that high pretreatment NLR was significantly associated with poor outcomes of OS (HR = 1.78, 95% CI = [1.59, 1.99]) and PFS (HR = 1.63, 95% CI = [1.39, 1.91]) in gastric cancer. Subgroup analyses stratified by country, study type, case load, analysis of HR, cutoff of pretreatment NLR, or treatment types arrived at the same conclusion. Pooled data based on different effect models and sensitivity analyses did not change the conclusion. Overall, high pretreatment NLR predicts the poor prognosis of inoperable gastric cancer patients with systemic therapy. Measurement of pretreatment NLR will assist clinicians with patient counseling and clinical treatment guiding accordingly.

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“…The goal is to increase the accuracy of detection to distinguish goblet cells from pseudogoblet cells. In addition, TFF3 showed strong staining on the mucosal surface biopsy of Barrett esophagus CaSPER samples [19]. TFF3 has a trefoil characteristic which contains 40 amino acids composed of three conserved disulfides.…”

Section: Casper (Cellulose Sponge the Detector Of Esophageal Cancer)mentioning

confidence: 97%

Cellulose Sponge, the Detector of Esophageal Cancer: Innovation for Early Detection of Esophageal Cancer without Biopsy?: A Mini Review

Hidayah

¹

,

Salsabila

²

2022

Open Access Maced J Med Sci

0

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Patients with esophageal cancer each year can reach 400,000 people. Inefficient screening methods and worsening symptoms, patients often come late. Squamous cell carcinoma, which is the cause of esophageal cancer, has percentage of 84% of all cancer incidences. So far, the current screening strategy is endoscopy with biopsy. This screening has the main side effect of bleeding in metaplastic area. Cellulose Sponge, the Detector of Esophageal Cancer (CaSPER), can be used for screening without a biopsy using a cellulose sponge. The method used in this mini review is an evidence-based method that focuses on evaluating pre-existing journals. The result is that CaSPER is able to provide strong cellular results of 98%, specificity of 100%, and sensitivity of 97%. Capsules made of glucose and cytosponge of cellulose will bring the metaplastic cells to the sponge. This screening is feasible, safe, comfortable, and without side effects. Using trefoil factor 3 as biomarker is able to distinguish between goblet and pseudogoblet cells. CaSPER is minimally invasive, cheaper, and easily accepted, so that in the future it is hoped that it can be mass produced, especially for areas with high esophageal cancer.

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The diagnostic and clinicopathological value of trefoil factor 3 in patients with gastric cancer: a systematic review and meta-analysis

Cited by 8 publications

References 39 publications

Diagnostic Value of Spiral CT and Magnetic Resonance Imaging Scanning in Gastric Cancer and Precancerous Lesions

Diagnostic Value of Spiral CT and Magnetic Resonance Imaging Scanning in Gastric Cancer and Precancerous Lesions

Pretreatment neutrophil-to-lymphocyte ratio predicts the benefit of gastric cancer patients with systemic therapy

Cellulose Sponge, the Detector of Esophageal Cancer: Innovation for Early Detection of Esophageal Cancer without Biopsy?: A Mini Review

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