The Diagnosis of Pleural Tumors Other Than Mesothelioma

Attanoos, Richard; Pugh, Matthew

doi:10.5858/arpa.2017-0537-ra

Cited by 38 publications

(19 citation statements)

References 119 publications

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“…According to some authors, even benign PSFT can be unpredictable (10-15% of cases), especially if the size of the tumor is larger than 10 cm and has infiltrated the pleural margins [7]. This is the reason why in the case of our patients, tumor resection was done with oncological margins of 2 cm and in association with histopathological examination from pleural margins (37 cases, 82.22%).…”

Section: Discussionmentioning

confidence: 87%

“…A Ki67 level <1% is suggestive for the lack of malignancy [1]. A more biological aggressiveness of PSFT is characterised by higher values of Ki-67 and p53 and variable CD-34 levels [7].…”

Section: Discussionmentioning

confidence: 99%

“…Stout and Murray (1942) were the first to identify the mesenchymal origin of pleural tumors, which was later confirmed by electronic microscopy and immunohistochemistry [6]. Over time, these tumors have had different names: localised mesothelioma, benign mesothelioma, fibrous mesothelioma, pleural fibroma, benign pleural fibroma, pleural fibromyxoma, localised fibrous tumor, and so on [7].…”

Section: Introductionmentioning

confidence: 99%

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Pleural Solitary Fibrous Tumors—A Retrospective Study on 45 Patients

et al. 2020

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Introduction: The purpose of this paper is to study the type, the clinical presentation, and the best diagnostic methods for pleural solitary fibrous tumors (PSFTs), as well as to evaluate which is the most appropriate treatment, especially as PSFTs represent a rare occurrence in the thoracic pathology. Material and Method: A retrospective study was conducted on a group of 45 patients submitted to surgery between January 2015 and December 2019. In most cases, the diagnosis was established through imaging studies—thoracic computed tomography (CT) scan with or without contrast—but also using magnetic resonance imaging (MRI) or positron emission tomography (PET) scans when data from CT scans were scarce. All patients were submitted to surgery with curative intent. Results: Most patients included in this study were asymptomatic, with this pathology being more common in patients over 60 years of age, and more common in women. The occurrence of malignant PSFT in our study was 17.77% (8 cases). All cases were submitted to surgery with curative intent, with a single case developing further recurrence. In order to achieve complete resection en bloc resection of the tumor with the chest wall, resection was performed in two cases, while lower lobectomy, pneumectomy, and hemidiaphragm resection, respectively, were needed in each case. Postoperative mortality was null. Conclusion: Thoracic CT scan remains the most important imagistic investigation in diagnosing. MRI is superior to thoracic CT, especially in cases that involved the larger blood vessels within the thorax, spinal column, or diaphragm. Complete surgical resection is the gold standard in treatment of PSFT, and the prognosis in benign cases is very good.

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Section: Discussionmentioning

confidence: 87%

“…A Ki67 level <1% is suggestive for the lack of malignancy [1]. A more biological aggressiveness of PSFT is characterised by higher values of Ki-67 and p53 and variable CD-34 levels [7].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pleural Solitary Fibrous Tumors—A Retrospective Study on 45 Patients

et al. 2020

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“…Imaging studies can rarely distinguish the primary lesion from a metastatic lesion [ 1 , 7 ]. Our primary mass has an obtuse margin with the chest wall, nodularity of the pleura, and local lymphadenopathy.…”

Section: Discussionmentioning

confidence: 99%

Primary Pleural Epithelioid Angiosarcoma With Extensive and Rapid Metastasis to Brain and Bilateral Adrenal Glands

Sinkler

Ullah

Wehrle

et al. 2020

Cureus

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A 64-year-old male presents with shoulder pain, arm pain, and a chronic cough. CT imaging of the thorax shows a large 8.0 x 6.7 cm mass with central necrosis in the left upper lung lobe with invasion into the chest wall with partial destruction of the second and third ribs, and left axillary adenopathy. Bilateral adrenal nodules are identified via CT imaging and subsequently biopsied. Histologically, the mass reveals sheets of atypical epithelioid cells with round nuclei and abundant eosinophilic cytoplasm. Immunostaining is positive for CD31, CD34, FLI-1, AE1/AE3, and CK7, diagnostic of primary epithelioid angiosarcoma. The patient developed symptoms of confusion, dizziness, and ataxia. An MRI showed metastatic brain lesions. One month later, the patient had worsening symptoms. Repeat imaging demonstrates enlargement of the bilateral adrenal masses, a new lesion posterior to the left kidney, and doubling of the size of the brain lesions. This case illustrates the metastatic potential and pattern of the spread of an aggressive primary pleural angiosarcoma that is not described elsewhere in current literature. It also highlights the importance of timely intervention based on the rapid metastatic progression of this neoplasm.

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“…Malignant mesothelioma (MM) is a rare aggressive tumor-family of pleura and lung, with an incidence of about 0.002% [ 1 , 2 ]. In most of the cases, MMs are located in pleural mesothelium, and only rarely in peritoneal cavities, tunica vaginalis or pericardium.…”

Section: Introductionmentioning

confidence: 99%

Cytogenomic characterization of three murine malignant mesothelioma tumor cell lines

et al. 2020

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Background Malignant mesothelioma (MM) is a rare aggressive cancer primary located in pleura and lung. MMs can be divided into biphasic, epithelioid and sarcomatoid subtypes. In majority of cases MMs are induced by asbestos fiber exposure. As latency period after asbestos exposure ranges between ~ 10 and 60 years MMs are mainly observed in elder people. Human MM, being a rare tumor type, lacks detailed cytogenetic data, while molecular genetic studies have been undertaken more frequently. However, murine MM cell lines are also regularly applied to get more insight into MM biology and to test new therapy strategies. Results Here the murine MM cell lines AB1, AB22 and AC29 were studied by molecular cytogenetics and molecular karyotyping. Interestingly, yet there were no genetic or genomic studies undertaken for these already in 1992 established cell lines. The obtained data on genomic imbalances in these murine cell lines was translated into the human genome as previously reported based on human and murine genomic browsers. Conclusions It turned out that all three cell lines showed high similarities in copy number variants as observed typically in human MM. Also, all three cell lines were most similar to human epithelioid MMs, and should be used as models therefore.

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The Diagnosis of Pleural Tumors Other Than Mesothelioma

Cited by 38 publications

References 119 publications

Pleural Solitary Fibrous Tumors—A Retrospective Study on 45 Patients

Pleural Solitary Fibrous Tumors—A Retrospective Study on 45 Patients

Primary Pleural Epithelioid Angiosarcoma With Extensive and Rapid Metastasis to Brain and Bilateral Adrenal Glands

Cytogenomic characterization of three murine malignant mesothelioma tumor cell lines

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