The Development or Exacerbation of Eating Disorder Symptoms After Topiramate Initiation

Lebow, Jocelyn; Chuy, Jeffrey A.; Cedermark, Kyle; Cook, Katlyn E.; Sim, Leslie

doi:10.1542/peds.2014-3413

Cited by 17 publications

(13 citation statements)

References 26 publications

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“…However, cases of topiramate triggering eating disorder symptoms in adolescents have been reported. 185 Other drugs, including naltrexone and ondansetron, are being used with some success in adult BN, although data are lacking to recommend their use more broadly. 169 Pharmacotherapy for BED…”

Section: Pharmacotherapy For Bnmentioning

confidence: 99%

Identification and Management of Eating Disorders in Children and Adolescents

2021

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Eating disorders are serious, potentially life-threatening illnesses afflicting individuals through the life span, with a particular impact on both the physical and psychological development of children and adolescents. Because care for children and adolescents with eating disorders can be complex and resources for the treatment of eating disorders are often limited, pediatricians may be called on to not only provide medical supervision for their patients with diagnosed eating disorders but also coordinate care and advocate for appropriate services. This clinical report includes a review of common eating disorders diagnosed in children and adolescents, outlines the medical evaluation of patients suspected of having an eating disorder, presents an overview of treatment strategies, and highlights opportunities for advocacy.

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Section: Pharmacotherapy For Bnmentioning

confidence: 99%

Identification and Management of Eating Disorders in Children and Adolescents

2021

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“…Further, topiramate in fixed dose combination with phentermine was reported to benefit binge eating behaviors in BED and BN 111 . However, there is a case report of an individual with ED misusing topiramate to promote weight loss 112 and another of several adolescents developing or exacerbating ED after initiating topiramate 113 . Thus, with caveats and the lack of studies in comorbid ED and SUD, topiramate may be of benefit for select persons with AUD and BN/BED.…”

Section: Managementmentioning

confidence: 99%

Identifying and Managing Eating Disorders in Persons Presenting for Addiction Treatment

Norris

Dahl

Jericho

et al. 2021

Canadian Journal of Addiction

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Objectives: Eating disorders (ED) are common in substance use disorders (SUD), yet often go unrecognized when presenting for addiction treatment. Unrecognized ED can potentially worsen treatment outcomes for both SUD and ED. Means to screen, diagnose, and manage ED when a person presents for addiction treatment are reviewed. Methods: Systematic searches using MEDLINE, Google Scholar, and PubMed augmented by references of found articles were completed using the search terms: eating disorder, anorexia nervosa, bulimia nervosa, alcohol, drugs, substance-related disorders, comorbidity, screening, diagnosis, management and treatment. Screening instruments and treatment options applicable to ED or SUD were reviewed for their applicability to persons with comorbid ED and SUD. Results: The SCOFF, Eating Attitudes Test-26 item version and Eating Disorder Examination-Questionnaire are means to screen for ED in persons with SUD. There were no screening instruments designed for both ED and SUD nor were there any pharmacologic treatment trials for comorbid ED and SUD. Psychotherapy trials of DBT and mindfulness incorporated into CBT for comorbid ED and SUD are supportive. Data from studies of ED or SUD alone suggest potential roles for specific medications and other psychotherapies for comorbid ED and SUD. Conclusions: ED often go undetected when a person enters addiction treatment, potentially worsening treatment outcomes. Standardized screening for ED is recommended for all persons, particularly women, entering addiction treatment followed by monitoring of ED behaviors during recovery. Pharmacotherapy currently is only adjunctive, whereas DBT or mindfulness incorporated into CBT have best evidence for comorbid ED and SUD. Objectifs: Les troubles de l’alimentation (TA) sont courants dans les troubles liés à l’utilisation de substances (TUS), mais passent souvent inaperçus lorsqu’ils se présentent pour un traitement de la dépendance. Un TA non reconnu peut potentiellement aggraver les résultats du traitement pour le TUS et le TA. Les moyens de dépister, de diagnostiquer et de gérer la dysfonction érectile lorsqu’une personne se présente pour un traitement de l’addiction sont examinés. Méthodes: Des recherches systématiques utilisant MEDLINE, Google Scholar et PubMed complétées par des références d’articles trouvés ont été complétées en utilisant les termes de recherche: trouble de l’alimentation, anorexie mentale, boulimie nerveuse, alcool, drogues, troubles liés à la substance, comorbidité, dépistage, diagnostic, gestion et traitement. Les instruments de dépistage et les options de traitement applicables aux TA ou TUS ont été examinés pour leur applicabilité aux personnes présentant des comorbidités de TA et TUS. Résultats: Le SCOFF, Eating Attitudes Test-26 item version (EAT-26) et Eating Disorder Examination-Questionnaire (EDE-Q) sont des moyens de dépister la dysfonction érectile chez les personnes atteintes de TUS. Il n’y avait aucun instrument de dépistage conçu à la fois pour les TA et TUS, ni d’essais de traitement pharmacologique pour les TA et TUS comorbides. Les essais de psychothérapie sur la DBT et la pleine conscience incorporés dans la CBT pour les comorbidités des TA et TUS sont favorables. Les données d’études sur les TA ou TUS seuls suggèrent des rôles potentiels pour des médicaments spécifiques et d’autres psychothérapies pour les comorbidités des TA et TUS. Conclusions: La dysfonction érectile passe souvent inaperçue lorsqu’une personne entame un traitement contre l’addiction, ce qui peut aggraver les résultats du traitement. Un dépistage standardisé de la dysfonction érectile est recommandé pour toutes les personnes, en particulier les femmes, entrant dans un traitement d’addiction suivi d’une surveillance des comportements du TA pendant la récupération. La pharmacothérapie n’est actuellement qu’un complément, alors que la DBT ou la pleine conscience incorporée à la CBT ont les meilleures preuves de comorbidité des TA et TUS.

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“…This research suggests conducting more thorough screening for a range of eating and weight concerns would be of benefit to all adolescents undergoing evaluation for orthostatic intolerance, no matter what their current BMI. 25 Because POTS symptoms contribute to abdominal pain and nausea, youth with orthostatic intolerance may be more likely to meet criteria for avoidant restrictive food intake disorder (ARFID). Unlike more well-known eating disorder diagnoses such as anorexia or bulimia nervosa, ARFID does not center on body image concerns or fear of weight gain.…”

Section: Implications For Practicementioning

confidence: 99%

Postural Orthostatic Tachycardia Syndrome and Disordered Eating: Clarifying the Overlap

Benjamin

Sim

Owens

et al. 2020

J Dev Behav Pediatr

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Objective: Postural orthostatic tachycardia syndrome (POTS) is estimated to occur in up to 1% of adolescents, with symptoms of dizziness, fatigue, and pain impacting daily functioning. However, many risk factors and symptoms for POTS overlap with those of youth with disordered eating, and adolescents with POTS may be at increased risk for developing eating disorders. Therefore, the present study sought to better understand this overlap. We hypothesized that patients with POTS would have higher than expected rates of weight change, restrictive eating patterns, and food sensitivities. Methods: We conducted a retrospective chart review of 96 adolescents and young adults diagnosed with POTS who were participating in a 3-week intensive interdisciplinary pain rehabilitation program. We conducted descriptive and correlational statistical analyses on data from self-report measures, biomarkers of nutritional status, and abstracted information about eating and weight concerns from medical notes. Results: Nearly 3 quarters of participants described engaging in restrictive eating, and more than half of them described experiencing weight loss. They also endorsed experiencing food allergies, celiac disease, and eating disorder at higher rates than would be expected in the general population. One-fifth of the sample had experienced invasive interventions to correct for nutritional imbalances, such as having a feeding tube. Conclusion: Weight and eating are clear areas of risk for patients with orthostatic intolerance. It is essential that treatment team members thoroughly screen for eating disturbances and make recommendations that support regular and balanced eating habits.

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The Development or Exacerbation of Eating Disorder Symptoms After Topiramate Initiation

Cited by 17 publications

References 26 publications

Identification and Management of Eating Disorders in Children and Adolescents

Identification and Management of Eating Disorders in Children and Adolescents

Identifying and Managing Eating Disorders in Persons Presenting for Addiction Treatment

Postural Orthostatic Tachycardia Syndrome and Disordered Eating: Clarifying the Overlap

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