The Development of the Interventricular Septum of the Human Heart; Correlative Morphogenetic Study

Goor, Daniel A.; Edwards, Jesse E.; Lillehei, C. Walton

doi:10.1378/chest.58.5.453

Cited by 76 publications

(35 citation statements)

References 13 publications

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“…It is evident, therefore, that the division of the membranous septum into its components cannot be dependent upon separate processes of development, as suggested by Odgers (1938) and endorsed by Kramer (1942) and Goor et al (1970). The different mechanisms invoked by these investigations may well be instrumental in closing the interventricular foramen, though this is also a contentious point.…”

Section: Discussionmentioning

confidence: 92%

“…However, can we be sure how these components are produced? Odgers (1938), endorsed by Goor et al (1970), argued that the atrioventricular component resulted from fusion of the right bulbar ridge with the right lateral atrioventricular cushion, while the interventricular component was formed by proliferating tubercles so as to obliterate the embryonic interventricular foramen. While this may be the mechanism of closure of the foramen, it is hard to envisage it producing two components of the membranous septum.…”

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confidence: 99%

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Developmental anatomy of the membranous part of the ventricular septum in the human heart.

Allwork¹,

Anderson²

1979

Heart

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suMMARY The anatomy of the membranous part of the ventricular septum is described in 25 hearts from patients ranging in age from 15 weeks of gestation to the ninth decade of adult life. Both atrioventricular and interventricular components were recognised in all the adult subjects, and the atrioventricular component was evident in all 25. The interventricular membranous septum was present in only 1 of the fetal hearts and 4 of the infant subjects. We consider that these findings indicate that the transformation of the membranous septum into atrioventricular and interventricular components occurs in the late fetal and early postnatal period rather than during closure of the embryonic interventricular foramen. It is associated with the liberation of the medial leaflet of the tricuspid valve from the muscular ventricular septum.The morphology of the membranous part of the ventricular septum is well described, particularly its division into atrioventricular and interventricular components (Walmsley, 1930;Odgers, 1938). However, can we be sure how these components are produced? Odgers (1938), endorsed by Goor et al. (1970), argued that the atrioventricular component resulted from fusion of the right bulbar ridge with the right lateral atrioventricular cushion, while the interventricular component was formed by proliferating tubercles so as to obliterate the embryonic interventricular foramen. While this may be the mechanism of closure of the foramen, it is hard to envisage it producing two components of the membranous septum. This is because the septum is divided into its portions by the annular attachment of the tricuspid valve leaflets, and these leaflets are as yet unformed at the time of closure of the secondary interventricular foramen. This fact has important consequences, because defects of the two components of the membranous septum are explained on the basis of different anomalous growth pattern (Goor and Lillehei, 1975). If the tricuspid leaflets are indeed formed late, this explanation would not be possible because any hole in the position of the membranous septum would be atrioventricular. Presence of an interventricular Received for publication 27 June 1978 defect would be dependent upon the secondary formation of the tricuspid annulus and its relation to the membranous septum. In an attempt, therefore, to elucidate the mode of formation of the components of the membranous septum, we have studied its morphology in fetal, infant, and adult human hearts. SubjectsTwenty-five hearts were studied. Five were from fetuses of 15 to 26 weeks' gestation, 10 were from infants from stillbirth to 1 year of age, and the remaining 10 were from subjects aged from 3 years to 85 years. This latter group was designated 'adult', though 3 hearts were from children aged 3, 5, and 8, respectively. These were considered as juvenile adults for the purpose of this study. None of the subjects had died from heart disease but coronary artery disease was evident in some of the elderly subjects. The fetal hearts were studied by his...

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Section: Discussionmentioning

confidence: 92%

mentioning

confidence: 99%

Developmental anatomy of the membranous part of the ventricular septum in the human heart.

Allwork¹,

Anderson²

1979

Heart

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“…VSD, as it was mentioned in the Introduction, is a heterogeneous CCVA including different developmental errors of ventricular septum [11][12][13][14][15][16][17][18], only the membranous and muscular groups of VSD were included to the study. However, cases with common ventricle (i.e.…”

Section: Study Design Of Cases With Vsdmentioning

confidence: 99%

“…The objective of our project is to estimate the possible etiological factors in the origin of different CCVA-types. VSD was evaluated in the first step; however, VSD is a heterogeneous CCVA including different developmental errors of ventricular septum [11][12][13][14][15][16][17][18] because it is composed from 4 parts: septum membranaceum, anterior septum, posterior smooth septum and posterior trabeculated septum. These 4 components of the ventricular septum are derived of 3 developmental processes: (i) the posterior septum forms from the ventricle, (ii) anterior septum from the conotruncal crest and (iii) the septum membranaceum from the endocardial cushions.…”

Section: Introductionmentioning

confidence: 99%

Ventricular septal defects in function of maternal sociodemographic aspects

Vereczkey¹,

Kósa²,

Csáky-Szunyogh

et al. 2012

Open Medicine

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AbstractThe objective of our project is to reveal the possible etiological factors of different congenital cardiovascular abnormalities. In this study, we evaluated single ventricular septal defect (VSD) after surgical correction or with lethal outcome. The birth outcomes of these cases in the function of maternal socio-demographic features were evaluated. Data are based on 1,659 VSD cases, 2,534 matched controls and 38,151 all controls without any defects, in addition in the mothers of 19,393 malformed controls with other isolated defects in the population-based large dataset of the Hungarian Case-Control Surveillance of Congenital Abnormalities. VSD had mild female excess with a higher rate of preterm birth and mainly low birth weight indicating intrauterine growth restriction of affected fetuses, particularly in males and full-term or average weighted cases. The mothers of cases with VSD had lower socioeconomic status and higher rate of smoking and particularly drinking habit. The evaluation of medically recorded pregnancy complications showed an association of gestational diabetes with a higher risk of VSD. In conclusion, the association of small localized size of VDS and obvious fetal growth restriction needs further explanation in these cases, while gestational diabetes, lower socioeconomic status and adverse lifestyle of pregnant women may have a role in the origin of VSD.

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“…These wax plate reconstruction methods were used by many other investigators until the early 1900s 1 . Subsequently serial histological sections of human embryos have been used to further investigate human cardiac development [2][3][4][5][6] . Based on analysis of histological sections and scaled reproductions of human embryos, Grant showed a large cushion in the developing heart at 6 6/7 weeks (CS 14) and separate AV valves at 9 1/7 weeks (CS 22) 2 .…”

Section: Introductionmentioning

confidence: 99%