The development of genomics applied to dairy breeding

Silva, Marcos V. B.; Santos, Daniel Jordan de Abreu; Boison, Solomon Antwi; Utsunomiya, Adam Taiti Harth; Carmo, Adriana Santana do; Sonstegard, Tad S.; Cole, J.B.; Tassell, C. P. van

doi:10.1016/j.livsci.2014.05.017

Cited by 23 publications

(21 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, conventional breeding strategies basing on phenotypic selection has met with a quite limited success for low heritability traits like clinical mastitis and its indicator somatic cell score (SCS) (Hinrichs et al, 2011). The emergency of genomic selection for udder health traits has provided a promising tool for the genetic improvement for mastitis resistance (Hayes and Goddard, 2001) and it has been successfully implemented in the breeding programs of dairy cattle in several countries due to their potential cost reduction and accuracy (Silva et al, 2014). However, since most single nucleotide polymorphisms (SNPs) used for genomic selection are linked to unknown causative mutations, the linkage disequilibrium must be readjusted over time due to recombination and genetic background in different populations (Abdel-Shafy et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Genetic mutations potentially cause two novel NCF1 splice variants up-regulated in the mammary gland, blood and neutrophil of cows infected by Escherichia coli

Zhang

Wang

et al. 2015

Microbiological Research

View full text Add to dashboard Cite

Neutrophil cytosolic factor 1 (NCF1) plays a crucial role in host defense against microbial pathogens. In this study, we investigated the potential alternative splicing patterns, expression and splice-relevant single nucleotide polymorphisms (SNPs) of the bovine NCF1 gene to increase insights into its potential role against bovine mastitis caused by Escherichia coli infection. Using RT-PCR and clone sequencing methods, we found two novel splice variants designed as NCF1-TV1 (retained intron 6) and NCF1-TV2 (retained part of intron 8), respectively, encoding two putative truncated proteins (239AA and 283AA). Two splice variants were drastically up-regulated in the mastitis-infected cows' mammary tissues, blood and neutrophils compared with these of healthy cows using real-time RT-PCR. Genomic sequencing analysis identified four novel SNPs g.10112 G>A, g.10766 T>C, SNPs g.12085 G>A and g.12430 T>C at the ends of intron 6 and intron 8 of NCF1. ESE motif predicted that the SNP (g.10766 T>C) might affect the binding with splicing-related factors and subsequently caused the production of aberrant splice variant NCF1-TV1, which is one of the potential reasons that the functional SNP was associated with increased milk somatic cell score in cow. Our results would help in better understanding the NCF1 gene function in the process against pathogen infection, and the effect of splicing-related SNP on the production of aberrant splice variant and careful functional characterization in dairy cattle.

show abstract

Section: Introductionmentioning

confidence: 99%

Genetic mutations potentially cause two novel NCF1 splice variants up-regulated in the mammary gland, blood and neutrophil of cows infected by Escherichia coli

Zhang

Wang

et al. 2015

Microbiological Research

View full text Add to dashboard Cite

show abstract

“…A significant shift in animal breeding occurred with the implementation of genomic selection in the United States, Great Britain, Ireland, New Zealand, Australia, the Netherlands, France, the Scandinavian countries, and Germany (Silva et al, 2014). Huge numbers of genomics markers of the livestock genome (single nucleotide polymorphisms-SNP) are available and, for instance, have been demonstrated for production traits such as lactation curve, milk, fat, and protein (Oliveira et al, 2019) and various health traits such as displaced abomasum (Zerbin et al, 2015;Lehner et al, 2018), cystic ovaries, displaced abomasum, ketosis, lameness, mastitis, metritis, retained placenta (Parker Gaddis et al, 2014), mastitis, metritis, retained placenta, displaced abomasum, ketosis, and lameness, (Vukasinovic et al, 2017), association between reproductive performance and serum IGF-1 (Gobikrushanth et al, 2018), ketosis (Parker Gaddis et al, 2018;Kroezen et al, 2018), and somatic cell score (Oliveira et al, 2019).…”

Section: Production and Reproductionmentioning

confidence: 99%

Transition Period of the Dairy Cow Revisited: II. Homeorhetic Stimulus and Ketosis With Implication for Fertility

Martens¹

2020

JAS

View full text Add to dashboard Cite

Dairy cows have been selected during the last century primarily for milk production, which has been increased by a factor 3-5 per lactation during this period without a concomitantly adequate increase of dry matter intake (DMI). This discrepancy between input and output is caused by a negative or minutely positive genetic correlation between milk yield and DMI and leads, in high-producing dairy cows in early lactation, to a severe and long-lasting negative energy balance (NEB) with distinct hormonal and metabolic alterations. Milk production during this period is regulated by homeorhesis with high priority for this trait, which is relatively uncoupled from DMI, and hence with possible restrictions of other functions. The extent and duration of the current NEB is a health risk and is probably one of the reasons for genetic correlations between milk yield and disease. The gap between input and output is closed by the mobilization of reserves characterized by a rapid increase of non-esterified fatty acids (NEFA) above the acute requirement, in turn leading to ectopic fat disposition in the liver and other organs. Therefore, fat liver and ketosis occur during early lactation within a phase of the priority of the homeorhetic (genetic) regulation of milk production at insufficient DMI. Ketosis is correlated with an impairment of fertility. The correlation between an early cause (ketosis) and a later effect (impaired fertility) cannot be explained satisfactorily, but possible epigenetic alterations look promising for future research. The revealed connection between homeorhesis, fat liver and ketosis, and the impairment of fertility provides an approach for discussions of these topics as a complex. The convergence between these issues should furthermore be extended to other production diseases. Since the genetic background of this interaction must not be neglected, the current breeding system should include further health traits with a predominant emphasis on parameters of metabolism and energy balance.

show abstract

“…The dairy industry had the advantage of having access to DNA repositories owing to the wide use of artificial insemination, which accelerated the building of training populations (Wiggans et al, 2009). In most European countries and North America, genomics are included in routine genetic evaluations of dairy cattle, with international AI bulls being marketed with GEBV (Silva et al, 2014). A number of beef cattle breeds has also invested in genomics with large numbers genotyped in North and South American countries as well as in the UK and on the European continent (Berry et al, 2016).…”

Section: Application Of Genomic Selectionmentioning

confidence: 99%

Genomics for the advancement of livestock production: A South African perspective

Marle-Köster

Visser

2018

SA J. An. Sci.

View full text Add to dashboard Cite

Most of the growth of human populations worldwide will be in developing countries, including South Africa. Natural resources are under immense pressure and animal scientists are faced with the challenges for increased efficiency and long-term sustainability of livestock production. Since the completion of the Human Genome Project, animal genomes have been mapped with genomics, enabling new opportunities for application in farm animal species. The use of microsatellite markers has made significant contributions to the insight in genetic characterisation of indigenous and local developed breeds in most farm species in South Africa and Africa. The single nucleotide polymorphic (SNP) marker discovery and development of commercial SNP arrays made genomic selection possible and genomic enhanced breeding values (GEBVs) are used widely in the First World. In South Africa, genomic programmes for beef and dairy cattle were established in 2015 and 2016, with the focus on building training populations for genomic selection. The SA Bonsmara breed was the first to receive GEBV. The availability of hard-to-measure phenotypes is limited, and these are the traits that hold the most potential for genomic selection and answering to the challenges of methane (CH 4) emissions and higher efficiency. Genome editing, which involves zinc-finger nucleases (ZFNs), transcription-activators such as endonucleases (TALEN) and RNA-programmable genome editor (CRISPR/CAS9), includes the most recent technology for application in precision genetics. Welfare and ethical concerns will be an important consideration in the acceptability of genome editing to consumers. Applications that benefit the animals are more acceptable to the public. The use of genome editing to produce polled cattle is one of the first applications with a direct welfare impact as it nullifies the need for painful dehorning. In this paper, genomic technology is reviewed with the focus on the most recent research trends and commercial application of genomics towards the genetic improvement of livestock with specific reference to South Africa.

show abstract

The development of genomics applied to dairy breeding

Cited by 23 publications

References 95 publications

Genetic mutations potentially cause two novel NCF1 splice variants up-regulated in the mammary gland, blood and neutrophil of cows infected by Escherichia coli

Genetic mutations potentially cause two novel NCF1 splice variants up-regulated in the mammary gland, blood and neutrophil of cows infected by Escherichia coli

Transition Period of the Dairy Cow Revisited: II. Homeorhetic Stimulus and Ketosis With Implication for Fertility

Genomics for the advancement of livestock production: A South African perspective

Contact Info

Product

Resources

About