The development of cross-tolerance between morphine and nicotine in mice

Zarrindast, Mohammad‐Reza; Khoshayand, Mohammad-Reza; Shafaghi, Bijan

doi:10.1016/s0924-977x(98)00030-3

Cited by 60 publications

(37 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The observation that nicotine ameliorates naloxone-precipitated opiate withdrawal in rats (Zarrindast and Farzin 1996) suggests that common neurobiological substrates may mediate nicotine and opiate withdrawal. Furthermore, in addition to the development of tolerance to the pharmacological actions of the respective drug, chronic opiate or nicotine administration in mice was shown to induce cross-tolerance to the antinociceptive and hypothermia-inducing effects of the other drug (Zarrindast et al 1999(Zarrindast et al , 2001. All these effects of opiates and nicotine are mediated by receptors that are abundant in the central nervous system: that is, metabotropic opioid receptors and nicotinic acetylcholine receptors, which are ionotropic pentameric complexes composed of different subunits (Gotti and Clementi 2004).…”

Section: Introductionmentioning

confidence: 97%

Neurosteroids in nicotine and morphine dependence

et al. 2005

View full text Add to dashboard Cite

Changes in neurosteroid concentrations mediated by activation of the HPA axis may both contribute to the early acquisition phase of nicotine or morphine addiction and serve to counteract the anxiety-like behavior associated with nicotine or morphine withdrawal. However, the evidence that nicotine withdrawal did not increase neurosteroids, unless precipitated by mecamylamine, suggests that the role of these neurosteroids in spontaneous nicotine withdrawal may not be clear.

show abstract

Section: Introductionmentioning

confidence: 97%

Neurosteroids in nicotine and morphine dependence

et al. 2005

View full text Add to dashboard Cite

show abstract

“…There are few articles on rodent dependence models, and the majority of these studies have utilized rats and/or focused on somatic signs as the sole behavioral measure of withdrawal (although see Damaj et al 2003). In addition, although tolerance to nicotine-induced hypothermia has been examined (see Salminen and Ahtee 2000), few articles have examined tolerance to nicotine-mediated analgesia (see Zarrindast et al 1999) in the mouse. Given that chronic nicotine produces behaviors other than somatic signs during withdrawal (see Damaj et al 2003) and hypothermia during tolerance, mouse dependence and tolerance models that incorporate additional behavioral assays may provide more complete models of these processes.…”

Section: Introductionmentioning

confidence: 98%

Nicotine physical dependence and tolerance in the mouse following chronic oral administration

et al. 2004

View full text Add to dashboard Cite

show abstract

“…In particular, cross-tolerance between morphine and nicotine has been proposed in the antinociception (Zarrindast et al, 1999;Biala and Weglinska, 2006), catalepsy (Zarrindast et al, 2002), and conditioned place preference paradigms . Neuronal nicotinic systems play an important role in learning, memory, and cognition (Rezvani and Levin, 2001).…”

Section: Introductionmentioning

confidence: 99%

Nicotine improves morphine‐induced impairment of memory: Possible involvement of N‐methyl‐D‐aspartate receptors in the nucleus accumbens

Ahmadi

Zarrindast

Haeri-Rohani

et al. 2007

Developmental Neurobiology

View full text Add to dashboard Cite

The possible involvement of N-methyl-D-aspartate (NMDA) receptors in the nucleus accumbens (NAc) in nicotine's effect on impairment of memory by morphine was investigated. A passive avoidance task was used for memory assessment in male Wistar rats. Subcutaneous (s.c.) administration of morphine (5 and 10 mg/kg) after training impaired memory performance in the animals when tested 24 h later. Pretest administration of the same doses of morphine reversed impairment of memory because of post-training administration of the opioid. Moreover, administration of nicotine (0.2 and 0.4 mg/kg, s.c.) before the test prevented impairment of memory by morphine (5 mg/kg) given after training. Impairment of memory performance in the animals because of post-training administration of morphine (5 mg/kg) was also prevented by pretest administration of a noncompetitive NMDA receptor antagonist, MK-801 (0.75 and 1 microg/rat). Interestingly, an ineffective dose of MK-801 (0.5 microg/rat) in combination with low doses (0.075 and 0.1 mg/kg) of nicotine, which had no effects alone, synergistically improved memory performance impaired by morphine given after training. On the other hand, pretest administration of NMDA (0.1 and 0.5 microg/rat), which had no effect alone, in combination with an effective dose (0.4 mg/kg, s.c.) of nicotine prevented the improving effect of nicotine on memory impaired by pretreatment morphine. The results suggest a possible role for NMDA receptors of the NAc in the improving effect of nicotine on the morphine-induced amnesia.

show abstract

The development of cross-tolerance between morphine and nicotine in mice

Cited by 60 publications

References 37 publications

Neurosteroids in nicotine and morphine dependence

Neurosteroids in nicotine and morphine dependence

Nicotine physical dependence and tolerance in the mouse following chronic oral administration

Nicotine improves morphine‐induced impairment of memory: Possible involvement of N‐methyl‐D‐aspartate receptors in the nucleus accumbens

Contact Info

Product

Resources

About