The development of compartmental macrocyclic Schiff bases and related polyamine derivatives

Vigato, P.A.; Tamburini, S.; Bertolo, L.

doi:10.1016/j.ccr.2006.11.016

Cited by 357 publications

(153 citation statements)

References 150 publications

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“…These ligands are readily available, versatile and, depending on the nature of the starting materials (primary amines and carbonyl precursors), they exhibit various denticities and functionalities. Moreover, the number, the nature, and the relative position of the donor atoms of a Schiff base ligand allow a good control over the stereochemistry at the metallic centers, as well as over the number of the metal ions within homo-and heteropolynuclear complexes [3]. All these advantages make Schiff bases very good candidates in the effort to synthesize metal complexes of interest in bioinorganic chemistry, catalysis, encapsulation, transport and separation processes, and magnetochemistry.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis, Crystal Structure and Electrochemical Studies of a Hydrazone Schiff Base Complex of Titanium(IV)

Hosseini‐Monfared

Nazari²,

Mayer³

et al. 2009

Zeitschrift Für Naturforschung B

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Section: Introductionmentioning

confidence: 99%

“…A red-orange crystal of 1 (0.174 × 0.065 × 0.03 mm 3 ) was investigated at 200(2) K on a Nonius Kappa CCD diffractometer with monochromatized MoK α radiation (λ = 0.71073Å) obtained from graded multilayer X-ray op- …”

Section: X-ray Structure Determinationmentioning

confidence: 99%

Synthesis, Crystal Structure and Electrochemical Studies of a Hydrazone Schiff Base Complex of Titanium(IV)

Hosseini‐Monfared

Nazari²,

Mayer³

et al. 2009

Zeitschrift Für Naturforschung B

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“…在众多的大环化合物中, 含氮、氧等杂原子的大环配体具有环腔大小可控、环内配位供体原子(氮、氧原子)数目可变 [4,5] , 特别是大环结构刚、柔性易于调整, 使得类似大环在同金属离子进行配位键合作用时, 一方面因为环缘上的氮、氧原子配位取向灵活多变, 易于得到新颖的配合物结构 [6,7] ; 另一方面, 有利于提高其与金属离子配位作用的选择性 [8] . 因此设计、合成含氮、氧等杂原子的有机大环, 并开展其与金属离子之间的配位化学研究一直受到人们的普遍青睐 [9] . [12] (有关晶体学数据详见辅助材料表 S1).…”

Section: Synthesis Structures Of Macrocyclic Compounds and Study On unclassified

Synthesis, Structures of Macrocyclic Compounds and Study on Recognition for La(Ⅲ) Ion

欧敏¹,

邓雅欣²,

王芳芳³

et al. 2013

Chin. J. Org. Chem.

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NMR, IR, MS and elemental analysis, respectively. The X-ray single crystal analysis reveals that the macrocycle 3 has a folding structure, and 4 shows a twisted unfolding structure. The study for the reaction of the macrocyclic compound 3 or 4 with a series of the rare earth ions is performed by UV-Vis absorption spectra technique, and the results show that the macrocycle 3 displayed a selective recognition for La 3＋ ion. Moreover, the JOB plot exhibited a 1∶1 (host∶guest) stoichiometry between the host 3 and La 3＋ , and the binding constant (K) was determined using UV-vis titration method, K＝7.59×10 3 .

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“…Schiff bases derived from an amine and carboxylic compounds belong to a class of ligands involved in the coordination of metal ions via azomethine nitrogen 10 . The C=N linkage is crucial for biological activity in azomethine derivatives, and it was reported that various azomethines are characterized to have roles against bacteria, fungi and cancer 11 .…”

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confidence: 99%

Antiproliferative Effects of Fluorine Substitute 3,5-di-<i>tert</i>-butylphenol Bearing Schiff Bases Using CFSE-Based Cell Proliferation Assay

Gürol¹,

Kasim²,

Süzergöz³

2017

Current Science

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The determination of antiproliferative properties of compounds on tumour cells is important for assessment of their efficacy in cancer treatment. CFSElabelled K562 cells were incubated with doxorubicin and ortho-or para-fluorosubstitute Schiff bases (compounds 1 and 2 respectively). CFSE intensities were analysed using flow cytometry. K562 cells treated with doxorubicin resulted in homogeneous high intensity fluorescence after 96 h of incubation. Schiff bases exhibited antiproliferative effects, but lower than doxorubicin. Our results reveal that CFSE assay can be used for determining in vitro antiproliferative features of anticancer drugs and/or compounds from herbal or chemical sources.Keywords: Cancer, CFSE, doxorubicin.THERE have been many attempts to explore new chemotherapeutic agents from chemical and herbal sources worldwide. The determination of cytotoxic and antiproliferative effects of organic compounds has crucial importance in the evaluation of anticancer potential 1 . Although there are some precise methods such as 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) or ATP-based tumour chemosensitivity (ATP-TCA) assays to determine the cytotoxic capacity of herbal or chemical compounds [2][3][4] , there are no precise methods to quantitively determine the antiproliferative effects of compounds or assess multiparameters in anticancer research.The carboxyfluorescein diacetate succinimidyl ester (CFSE) assay is currently used to determine cell proliferation with flow cytometry 5 . The CFSE assay is based on general protein labelling by CFSE in which an aminoreactive dye forms stable covalent bonds with cell proteins [6][7][8] . An equal and progressive division of CFSE fluorescence occurs within daughter cells after each cellular division which suggests in vitro cell proliferation 9 . This fluorescent cell tracking assay can be a powerful tool to study the antiproliferative effects of anticancer drugs or herbal and chemical compounds in vitro.Schiff bases derived from an amine and carboxylic compounds belong to a class of ligands involved in the coordination of metal ions via azomethine nitrogen 10 . The C=N linkage is crucial for biological activity in azomethine derivatives, and it was reported that various azomethines are characterized to have roles against bacteria, fungi and cancer11 . An appreciable amount of Schiff-base complexes are quite successful models of biological compounds 12 . Fluorinated compounds have recently drawn attention due to their therapeutic applications in various medical areas 13 . 5-Fluorouracil (5-FU), a synthetic flourinated antineoplastic agent, is being used as an antimetabolite to treat malignancies such as breast, head, neck and gastrointestinal malignancies 14 . 5-FU irreversibly inhibiting thymidylate synthase can cause the death of rapidly dividing cancerous cells 15 . Tamoxifen is another fluorinated compound used for treatment of hormonedependent breast cancer as an oestrogen antagonist 16 . Gemcitabine is another fluorinated compound used in the...

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The development of compartmental macrocyclic Schiff bases and related polyamine derivatives

Cited by 357 publications

References 150 publications

Synthesis, Crystal Structure and Electrochemical Studies of a Hydrazone Schiff Base Complex of Titanium(IV)

Synthesis, Crystal Structure and Electrochemical Studies of a Hydrazone Schiff Base Complex of Titanium(IV)

Synthesis, Structures of Macrocyclic Compounds and Study on Recognition for La(Ⅲ) Ion

Antiproliferative Effects of Fluorine Substitute 3,5-di-<i>tert</i>-butylphenol Bearing Schiff Bases Using CFSE-Based Cell Proliferation Assay

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