The Development of a Polysulfone Membrane

Streicher, E; Schneider, H.

doi:10.1159/000410761

Cited by 37 publications

(14 citation statements)

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“…Backfiltration is the local movement of fluid from the dialysis solution to the blood stream that has been previously predicted to occur during hemodialysis with highly permeable membranes [4][5][6][7][8][9], The present study permits for the first time a comparison between direct experimental measurements of backfiltration and previous theoretical predictions.…”

Section: Discussionmentioning

confidence: 82%

“…Last, the backfiltration rate measured in the present study at a blood flow rate of 210 ml/ min compares favorably with that predicted in certain previous theoretical studies. Un der similar conditions, for example, Streicher and Schneider [5] predicted a backfiltration rate of 6 ml/min. Bosch et al [6] one of 5 ml/min.…”

Section: Discussionmentioning

confidence: 94%

“…These latter issues regarding the use of dialyzers containing highly perme able membranes have effected today's heightened concern over the quality of dialy sis solution [1][2][3]. Such concerns over dialy sis solution quality become particularly acute when membranes having a high water permeability are employed, since fluid movement from the dialysis solution to the bloodstream, a phenomenon termed backfiltration [4][5][6][7][8][9], can occur. Although the occur rence of and the clinical consequences result ing from dialysate-borne contaminations during chronic hemodialysis treatment are at present unclear, it seems prudent to employ both a dialysis solution of the highest quality and dialyzers that eliminate or, at the very least, minimize backfiltration.…”

Section: Introductionmentioning

confidence: 99%

“…Previous work concerning backfiltration in hemodialyzers with highly permeable membranes has been confined primarily to theoretical studies [4][5][6][7][8][9]. Empirical values of input and output blood pressure, input and output dialysate pressure, and membrane wa ter permeability have been employed in theo retical models to predict backfiltration rates for the Hemoflow F60 hemodialvzer, ranging from approximately 5 ml/min [5][6][7] to 20 ml/ min [4] when operating under typical clinical conditions.…”

Section: Introductionmentioning

confidence: 99%

“…Empirical values of input and output blood pressure, input and output dialysate pressure, and membrane wa ter permeability have been employed in theo retical models to predict backfiltration rates for the Hemoflow F60 hemodialvzer, ranging from approximately 5 ml/min [5][6][7] to 20 ml/ min [4] when operating under typical clinical conditions. The predicted rates of backfiltra tion vary because of different assumptions made in formulating the theoretical models.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Measurement of Backfiltration Rates during Hemodialysis with Highly Permeable Membranes

Leypoldt¹,

Schmidt²,

Gurland³

1991

Blood Purif

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A method for determining local transmembrane fluid movement in a commercial hemodialyzer at low dialysate flow rates by measuring changes along the dialyzer length in the local concentration of a marker macromolecule added to the dialysis solution has been developed. The method was evaluated in vitro at zero net ultrafiltration using dialyzers containing polysulfone (n = 4) and cuprophane (n = 3) membranes. The local concentration of the marker macromolecule along the dialyzer length was higher than the input dialysate concentration only during experiments with dialyzers containing polysulfone membranes. These observations provide direct empirical evidence that fluid movement in the dialysate to blood direction, i.e., backfiltration, occurs during hemodialysis with this highly permeable membrane. Net rates of backfiltration for the dialyzer containing the polysulfone membrane were also calculated from changes in the local concentration of the marker macromolecule and mass balance considerations. The calculated backfiltration rates increased with increasing blood flow rate and trended upward with increasing dialysate flow rate. The described methodology provides a novel approach for the further characterization of fluid and solute transport during hemodialysis with highly permeable membranes.

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