The determination of acrylamide in environmental and drinking waters by large-volume injection – hydrophilic-interaction liquid chromatography and tandem mass spectrometry

Backe, Will J.; Yingling, Virginia; Johnson, Todd M.

doi:10.1016/j.chroma.2014.02.005

Cited by 56 publications

(27 citation statements)

References 35 publications

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“…At present, a great number of methods have been developed to quantitatively analyze the AM monomer, including different extraction and cleanup procedures for different food matrixes. Most detection methods reported in the literature are mainly based on gas chromatography (GC) (Blanch et al 2013), liquid chromatography (LC) (Backe et al 2014), LC-MS (Bagdonaite et al 2008), and GC-MS (Soares et al 2006). Although these methods have reliable sensitivity, they often require qualified personnel, complex pretreatment steps, and high cost.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Sensor based on Imprinted Sol-Gel Polymer on Au NPs-MWCNTs-CS Modified Electrode for the Determination of Acrylamide

et al. 2015

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A sensitive molecularly imprinted electrochemical sensor was successfully constructed for the detection of acrylamide (AM). It is based on a glassy carbon electrode modified with a composites prepared from gold nanoparticles, multiwalled carbon nanotubes, and chitosan along with a sol-gel-based molecularly imprinted polymer (MIP) film. The latter was prepared using AM as the template molecule, 3-aminopropyltrimethoxysilane as the functional monomer, and tetraethoxysilane as the cross-linker. The MIP sensor showed a linear current response to the target AM concentration in the range from 0.05 to 5 μg mL −1 at a working voltage of 0-0.4 V with a lower detection limit of 0.028 μg mL −1 (S/N=3). It was successfully applied to the detection of AM in potato chips. HPLC analysis was also conducted to detect AM in the same samples to demonstrate the applicability of the electrochemical MIP sensor.

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Section: Introductionmentioning

confidence: 99%

Electrochemical Sensor based on Imprinted Sol-Gel Polymer on Au NPs-MWCNTs-CS Modified Electrode for the Determination of Acrylamide

et al. 2015

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“…At the same time, the improved desolvation within the ESI mass source offers a better sensitivity and a lower limit of detection [18]. HILIC has been successfully applied to the analysis of several classes of compounds such as acrylamide [19], saponins [16], organophosphorus [20], and so on, but the application to the determination of phenethylamines, a main class of ˇ2-adrenoceptor agonists, has not been reported yet. In addition, unlike RPLC, so far the retention mechanisms of HILIC are still not well identified [21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of bambuterol and its two major metabolites in human plasma by hydrophilic interaction ultra-performance liquid chromatography–tandem mass spectrometry

Zhou

Cheng

Zou

et al. 2014

Journal of Chromatography B

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“…This postulation is based on the review by Jandera et al 63 who attributed this on-column focussing to weak eluents. Related to this observation is the use of dichloromethane in place of water for injection of acrylamide by Backe et al 65 While both dichloromethane and THF have similar polarity (polarity indices of 3.1 and 4 respectively), THF has the advantage of 100 % solubility in water. This implies that THF has the ability to penetrate the pseudo-stagnant aqua layer on the surface of the HILIC column thereby enhancing the partitioning of the analytes into the aqua layer.…”

Section: The Moderately Polar Aprotic Diluent For Analyte Injectionmentioning

confidence: 99%

Comparative study of different column types for the separation of polar basic hallucinogenic alkaloids

et al. 2016

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The number of hallucinogenic compounds that have been separated simultaneously by liquid chromatography is limited. This research aimed to identify a column(s) that can allow for separation of several hallucinogens. The extent of separation of seven polar hallucinogenic tryptamine and phenethylamine derived alkaloids containing a basic N atom that becomes protonated at low pH values were investigated on five reverse-based columns and one hydrophilic interaction liquid chromatography (HILIC) column. An RP-phenyl and a negatively charged fused core HILIC were identified and recommended as effective columns in this regard. This research is the first to introduce a HILIC column in separation of hallucinogenic alkaloids and to simultaneously study the separation of the two principal psychoactive agents, muscimol and psilocin. The results of this study showed that better separation in HILIC columns can be achieved if an aprotic diluent of relatively lower polarity is used to introduce analytes into a mobile phase of higher polarity. Tetrahydrofuran was recommended where acetonitrile is used as the organic component of the mobile phase.

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The determination of acrylamide in environmental and drinking waters by large-volume injection – hydrophilic-interaction liquid chromatography and tandem mass spectrometry

Cited by 56 publications

References 35 publications

Electrochemical Sensor based on Imprinted Sol-Gel Polymer on Au NPs-MWCNTs-CS Modified Electrode for the Determination of Acrylamide

Electrochemical Sensor based on Imprinted Sol-Gel Polymer on Au NPs-MWCNTs-CS Modified Electrode for the Determination of Acrylamide

Simultaneous determination of bambuterol and its two major metabolites in human plasma by hydrophilic interaction ultra-performance liquid chromatography–tandem mass spectrometry

Comparative study of different column types for the separation of polar basic hallucinogenic alkaloids

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