The detection of hepatocellular carcinoma (HCC) from patients’ breath using canine scent detection: a proof-of-concept study

Kitiyakara, Taya; Redmond, Susan; Unwanatham, Nattawut; Rattanasiri, Sasivimol; Thakkinstian, A; Tangtawee, Pongsatorn; Mingphruedhi, Somkit; Sobhonslidsuk, Abhasnee; Intaraprasong, Pongphob; Kositchaiwat, Chomsri

doi:10.1088/1752-7163/aa7b8e

Cited by 22 publications

(23 citation statements)

References 35 publications

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“…In 2010, Willis et al published a clinical investigation on bladder cancer [8], after having published a proof-of-principle study in 2004 [9]. Subsequent studies have been performed to investigate the ability of dogs to detect colorectal cancer [10], lung [11][12][13], prostate [14][15][16], and liver [17] cancers, and melanoma [18,19]. Regarding other non-infectious diseases, several studies have suggested that dogs can be used as "alert dogs" for diabetic [20][21][22] and epileptic patients [23], to improve patient quality of life.…”

Section: Introductionmentioning

confidence: 99%

Can the detection dog alert on COVID-19 positive persons by sniffing axillary sweat samples? A proof-of-concept study

Sarkis²,

et al. 2020

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The aim of this proof-of-concept study was to evaluate if trained dogs could discriminate between sweat samples from symptomatic COVID-19 positive individuals (SARS-CoV-2 PCR positive) and those from asymptomatic COVID-19 negative individuals. The study was conducted at 2 sites (Paris, France, and Beirut, Lebanon), followed the same training and testing protocols, and involved six detection dogs (three explosive detection dogs, one search and rescue dog, and two colon cancer detection dogs). A total of 177 individuals were recruited for the study (95 symptomatic COVID-19 positive and 82 asymptomatic COVID-19 negative individuals) from five hospitals, and one underarm sweat sample per individual was collected. The dog training sessions lasted between one and three weeks. Once trained, the dog had to mark the COVID-19 positive sample randomly placed behind one of three or four olfactory cones (the other cones contained at least one COVID-19 negative sample and between zero and two mocks). During the testing session, a COVID-19 positive sample could be used up to a maximum of three times for one dog. The dog and its handler were both blinded to the COVID-positive sample location. The success rate per dog (i.e., the number of correct indications divided by the number of trials) ranged from 76% to 100%. The lower bound of the 95% confidence interval of the estimated success rate was most of the time higher than the success rate obtained by chance after removing the number of mocks from calculations. These results provide some evidence that detection dogs may be able to discriminate between sweat samples from symptomatic COVID-19 individuals and those from asymptomatic COVID-19 negative individuals. However, due to the limitations of this proof-of-concept study (including using some COVID-19 samples more than once and potential confounding biases), these results must be confirmed in validation studies.

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Section: Introductionmentioning

confidence: 99%

Can the detection dog alert on COVID-19 positive persons by sniffing axillary sweat samples? A proof-of-concept study

Sarkis²,

et al. 2020

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“…Numerous studies have suggested that dogs seem able to detect human diseases [4], such as bladder [5,6], colon [7,8], prostate [9][10][11], and liver [12] cancers, melanoma [13,14], diabetes [15][16][17][18],epileptic fits [19], malaria [20], and bacteriological diseases [21,22]. The high performances of the dogs in these studies encouraged further research [23].…”

Section: Introductionmentioning

confidence: 99%

Use Of Canine Olfactory Detection For COVID-19 Testing Study On U.A.E. Trained Detection Dog Sensitivity

Marzooqi¹,

Lecoq-Julien

Hammadi³

et al. 2021

Preprint

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This study aimed to evaluate the sensitivity of 21 dogs belonging to different United Arab Emirates (UAE) Ministry of Interior (MOI), trained for COVID-19 olfactory detection.The study involved 17 explosives detection dogs, two cadaver detection dogs and two dogs with no previous detection training. Training lasted two weeks before starting the validation protocol. Sequential five and seven-cone line-ups were used with axillary sweat samples from symptomatic COVID-19 individuals (SARS-CoV-2 PCR positive) and from asymptomatic COVID-19 negative individuals (SARS-CoV-2 PCR negative). A total of 1368 trials were performed during validation, including 151 positive and 110 negative samples. Each line-up had one positive sample and at least one negative sample. The dog had to mark the positive sample, randomly positioned behind one of the cones. The dog, handler and data recorder were blinded to the positive sample location.The calculated overall sensitivities were between 71% and 79% for three dogs, between83% and 87% for three other dogs, and equal to or higher than 90% for the remaining 15 dogs (more than two thirds of the 21 dogs).After calculating the overall sensitivity for each dog using all line-ups, “matched” sensitivities were calculated only including line-ups containing COVID-19 positive and negative samples strictly comparable on confounding factors such as diabetes, anosmia, asthma, fever, body pain, diarrhoea, sex, hospital, method of sweat collection and sampling duration. Most of the time, the sensitivities increased after matching.Pandemic conditions in the U.A.E., associated with the desire to use dogs as an efficient mass-pretesting tool has already led to the operational deployment of the study dogs.Future studies will focus on comparatives fields-test results including the impact of the main COVID-19 comorbidities and other respiratory tract infections.

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“…However, the following studies have demonstrated canine cancer detection for cancer screening is promising, feasible, and safe (Table 3) [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

“…Detection threshold has been shown to be as low as 1.5 parts per trillion (ppt) [10]. Trained dogs can successfully discriminate between patients with cancers of skin [11,12], bladder [13], lung [14][15][16][17][18], breast [14,19,20], prostate [20][21][22] ovary [23][24][25], colorectal [19,26], liver [27], uterine cervix [28] from controls on the basis of odors in breath, urine, blood or cell culture medium. However, the canine cancer detection testing for breast cancer using human urine samples has not yet been attempted.…”

Section: Introductionmentioning

confidence: 99%

Breast Cancer Detection From a Urine Sample by Dog Sniffing

Kure

Iida

Yamada

et al. 2020

Preprint

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Background: Breast cancer is a leading cause of cancer death worldwide. Several studies have demonstrated that dog can sniff and detect cancer in the breath or urine sample of a patient. Objective: The aim of this study is to assess whether the trained dog can detect breast cancer from urine samples.Methods: A nine-year-old female Labrador Retriever was trained to identify cancer from urine samples of breast cancer patients. Urine samples from patients histologically diagnosed with primary breast cancer, those with non-breast malignant diseases, and healthy volunteers were obtained, and a double-blind test was performed. Results: 40 patients with breast cancer, 142 patients with non-breast malignant diseases, and 18 healthy volunteers were enrolled, and their urine samples were collected. In 40 times out of 40 runs of a double-blind test, the trained dog could correctly identify urine samples of breast cancer patients. Sensitivity and specificity of this breast cancer detection method using dog sniffing were both 100%.Conclusions: The trained dog in this study could accurately detect breast cancer from urine samples of breast cancer patients. These results indicate the feasibility of a method to detect breast cancer from urine samples using dog sniffing in the diagnosis of breast cancer.

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The detection of hepatocellular carcinoma (HCC) from patients’ breath using canine scent detection: a proof-of-concept study

Cited by 22 publications

References 35 publications

Can the detection dog alert on COVID-19 positive persons by sniffing axillary sweat samples? A proof-of-concept study

Can the detection dog alert on COVID-19 positive persons by sniffing axillary sweat samples? A proof-of-concept study

Use Of Canine Olfactory Detection For COVID-19 Testing Study On U.A.E. Trained Detection Dog Sensitivity

Breast Cancer Detection From a Urine Sample by Dog Sniffing

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