The detection and measurement of interleukin-6 in venous and capillary blood samples, and in sweat collected at rest and during exercise

Faulkner, Simon; Spilsbury, Kate L.; Harvey, Janet; Jackson, Andrew P.; Huang, Jingfeng; Platt, Mark; Tok, Alfred Iing Yoong; Nimmo, Myra A.

doi:10.1007/s00421-014-2851-8

Cited by 32 publications

(25 citation statements)

References 37 publications

(55 reference statements)

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“…Firefighters' HR decreased across the simulation, but there were no significant differences found between conditions. Conclusion Findings highlight the protective role an 8-h sleep opportunity between shifts of firefighting work has on and norepinephrine) caused by the activation of the sympathetic-adrenal-medullary (SAM) system (Chandola et al 2010;Faulkner et al 2014). The release of catecholamines can reduce activity of the parasympathetic nervous system, resulting in an increased heart rate (HR; Chandola et al 2010;Faulkner et al 2014).…”

Section: Introductionmentioning

confidence: 88%

“…Conclusion Findings highlight the protective role an 8-h sleep opportunity between shifts of firefighting work has on and norepinephrine) caused by the activation of the sympathetic-adrenal-medullary (SAM) system (Chandola et al 2010;Faulkner et al 2014). The release of catecholamines can reduce activity of the parasympathetic nervous system, resulting in an increased heart rate (HR; Chandola et al 2010;Faulkner et al 2014). Under normal circumstances, activation of these physiological functions is expected to occur; however, exposure to particularly intense, or long periods of occupational-related stress over multiple days, can exacerbate and dysregulate the HPA-axis and SAM system response resulting in the sustained elevation of cortisol (Dabrowski 2008;Wolkow et al 2015) and HR (Meier-Ewert et al 2004;van Leeuwen et al 2009).…”

Section: Introductionmentioning

confidence: 95%

“…This indicates that exposure to sleep restriction could be a significant stressor for emergency workers that may contribute to a simultaneous dysregulation of cortisol and HR. The cumulative effects may pose a risk to chronic health outcomes (Dabrowski 2008;Faulkner et al 2014;Mackin and Young 2004;Silverman and Sternberg 2012;Tanskanen et al 2011), and thus, the impact of sleep restriction and physical work on HR and cortisol among firefighters requires further investigation.…”

Section: Introductionmentioning

confidence: 98%

“…Under normal circumstances, activation of these physiological functions is expected to occur; however, exposure to particularly intense, or long periods of occupational-related stress over multiple days, can exacerbate and dysregulate the HPA-axis and SAM system response resulting in the sustained elevation of cortisol (Dabrowski 2008;Wolkow et al 2015) and HR (Meier-Ewert et al 2004;van Leeuwen et al 2009). Chronic dysregulation of these systems has been associated with adverse health outcomes such as cardiovascular disease (CVD) and depression (Dabrowski 2008;Faulkner et al 2014;Mackin and Young 2004;Silverman and Sternberg 2012;Tanskanen et al 2011), both prevalent in firefighting populations Carey et al 2011;Cook and Mitchell 2013;Kales et al 2007;Wolkow et al 2014). As occupational stressors pose a potential risk to firefighters' health, there is a need to understand their effect on neuroendocrine responses in order to inform future evidence-based recommendations aimed at ensuring the safety of firefighting personnel.…”

Section: Introductionmentioning

confidence: 98%

“…These include the release of cortisol from the hypothalamic-pituitary-adrenal (HPA)-axis (Chandola et al 2010;Faulkner et al 2014;Tsigos and Chrousos 2002) and the secretion of catecholamines (epinephrine…”

Section: Introductionmentioning

confidence: 99%

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The impact of sleep restriction while performing simulated physical firefighting work on cortisol and heart rate responses

Wolkow

Aisbett

Reynolds

et al. 2015

Int Arch Occup Environ Health

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Findings highlight the protective role an 8-h sleep opportunity between shifts of firefighting work has on preserving normal cortisol levels when compared to a 4-h sleep opportunity which resulted in elevated afternoon and evening cortisol. Given the adverse health outcomes associated with chronically high cortisol, especially later in the day, future research should examine how prolonged exposure to firefighting work (including restricted sleep) affects firefighters' cortisol levels long term. Furthermore, monitoring cortisol levels post-deployment will determine the minimum recovery time firefighters need to safely return to the fire-ground.

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Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The impact of sleep restriction while performing simulated physical firefighting work on cortisol and heart rate responses

Wolkow

Aisbett

Reynolds

et al. 2015

Int Arch Occup Environ Health

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Wearable Sweat Management Technologies

Wei,

Li,

Dai

et al. 2024

Adv Materials Technologies

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The aging population and increasing prevalence of diseases among younger individuals have heightened the pressing demand for wearable health monitoring devices among the general public. In comparison to self‐health monitoring at physical signal level, wearable biochemical monitoring can provide more comprehensive and insightful information regarding one's own health status. Wearable sweat‐sensing technologies hold great potential for non‐invasive and continuous biochemical monitoring, and have emerged as a focal point of wearable health monitoring research. The effective management of sweat, encompassing convenient induction, reliable collection, and efficient flow control and storage, is fundamental in wearable sweat sensing. To elucidate the research progression in these aspects, this review first summarizes sweat secretion mechanisms, induction method, and sampling mode. Additionally, detailed summaries and discussion on sweat sampling and transport modes are provided. Furthermore, within the context of epidermal microfluidics, the technologies on sweat flow control and storage management based on microvalves are discussed. Lastly, current commercialization and key challenges are summarized.

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Myokine secretion during moderate‐intensity physical activity: Dose–response of interleukin 6 to walking duration

Kistner,

Tavormina,

Lieberman

2024

American J Hum Biol

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During vigorous physical activity, contracting muscles secrete a variety of immunomodulatory and metabolic factors called myokines that perform a variety of functions. Foremost among these is interleukin 6 (IL‐6), which increases fatty acid mobilization and stimulates anti‐inflammatory cytokine release. Despite being well characterized in vigorous exercise contexts, whether IL‐6 is secreted during moderate‐intensity activities such as walking is unclear. This is especially pertinent as regular walking is one of the oldest and most common forms of physical activity and comes with a variety of health benefits, which may be coordinated in part by IL‐6 signaling. To test the hypothesis that IL‐6 release occurs during evolutionarily normal physical activity contexts like long distance walking, we performed a dose–response experiment to test the effect of walking duration on IL‐6 secretion. Thirteen participants completed four moderate‐intensity walking trials (55% HRmax) of varying durations (30 min, 1 h, 2 h, and 3 h) in a randomized order with intervening washout periods of at least 1 week. Using a linear mixed effects model, we found that IL‐6 levels modestly increased during only the 2 h and 3 h walking trials. These results suggest that small frequent increases in IL‐6 signaling may be an important mechanism underlying the health benefits of regular walking. Furthermore, this finding raises the possibility that IL‐6 secretion is an adaptation to fuel physical activity, especially during periods of negative energy balance.

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The detection and measurement of interleukin-6 in venous and capillary blood samples, and in sweat collected at rest and during exercise

Cited by 32 publications

References 37 publications

The impact of sleep restriction while performing simulated physical firefighting work on cortisol and heart rate responses

The impact of sleep restriction while performing simulated physical firefighting work on cortisol and heart rate responses

Wearable Sweat Management Technologies

Myokine secretion during moderate‐intensity physical activity: Dose–response of interleukin 6 to walking duration

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