The Detailed Distribution of MHC Class Ii Antigens in Normal Human Organs

As, Daar; Fuggle, Susan V.; Fabre, John W.; Ting, A.; Morris, Peter J.

doi:10.1097/00007890-198409000-00019

Cited by 397 publications

(160 citation statements)

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“…It has been reported that no LC with typical Birbeck granules were apparent in normal human (28) or rat tracheal epithelium, but such cells have been detected in tracheal tissue in vitamin A deficiency (29), and in alveolar tissue in certain disease states (28). Although the expression of MHC class II antigens by nonlymphoid tissues has been extensively studied, bronchial epithelium has been described as either diffusely positive (8,30) or completely negative (31,32). In tissue samples from 3 of our 15 patients, anti-class II reagents produced diffuse staining; however, in the epithelial cells from the other 12 patients, the test results were negative.…”

Section: Discussionmentioning

confidence: 81%

Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura.

Sertl¹,

Takemura²,

Tschachler³

et al. 1986

The Journal of Experimental Medicine

340

184

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In this study, we identified a population of dendritic cells (DC) that exists throughout human and mouse pulmonary tissues, including the trachea, bronchi, alveoli, and visceral pleura. In human tissue, these DC were shown to be positive for HLA-DR and T200 antigens. In the mouse, the DC expressed not only Ia and the T200 antigen, but also Fc-IgG and C3bi receptors. Unlike alveolar macrophages, the DC were negative for nonspecific esterase staining and shared ultrastructural similarities with the DC described by Steinman (1), and with Langerhans' cells, even though they did not contain Birbeck granules. We were able to demonstrate that mouse pulmonary DC function in antigen presentation, as observed with the other DC. Thus, the respiratory tract contains DC that are capable of functioning in antigen presentation and that may be important in pulmonary immune responses.

show abstract

Section: Discussionmentioning

confidence: 81%

Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura.

Sertl¹,

Takemura²,

Tschachler³

et al. 1986

The Journal of Experimental Medicine

340

184

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“…In normal livers MHC class I antigens are expressed on the sinusoidal cells, large vessel and sinusoidal endothelia, biliary epithelium, dendritic cells and weakly, if at all, on hepatocytes. Class II antigens are found only on the sinusoidal cells, capillary endothelium and dendritic cells found in the portal connective tissue and in the connective tissue immediately subjacent to the terminal hepatic venules (5)(6)(7)25). Mter liver transplantation, alterations occur in the distribution of these antigens.…”

Section: Discussionmentioning

confidence: 99%

Recognition of major histocompatibility complex antigens on cultured human biliary epithelial cells by alloreactive lymphocytes

et al. 1991

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We have developed an in vitro system to study the interactions between biliary epithelium and lymphocytes using cultured human biliary epithelial cells. No class II antigens were detected by immunoperoxidase staining of the normal biliary epithelial cells, but alloactivated lymphocyte culture supernatants were able to induce class II expression. The activity of the supernatants was blocked with an anti-γ-interferon monoclonal antibody. In addition, recombinant human γ-interferon alone induced the expression of class II antigens and increased the intensity of class I staining of cultured biliary epithelial cells. Biliary epithelial cell-induced proliferation of alloreactive T lymphocytes demonstrated that the major histocompatibility complex molecules carry functional lymphocyte-activating determinants. The recognition of major histocompatibility complex determinants was confirmed by monoclonal antibody-blocking studies and by stimulation of an alloreactive T-cell clone. However, the biliary epithelial cells were much less potent stimulators than arterial endothelial cells tested in the same assay system.The biliary epithelium is a major target of lymphocytic attack in human liver allograft rejection and in many immunologically mediated liver diseases such as PBC (1,2). The immune damage in these disorders is thought to be mediated primarily by T cells. Major histocompatibility complex (MHC) antigens are likely the target of lymphocytic attack in rejection (3), and, although the target antigens in PBC have not yet been identified, the aberrant expression of class II antigens seen on the bile ducts in PBC livers has been hypothesized to playa role in the disease (4).The biliary epithelium in normal livers expresses class I but not class II human leukocyte antigens (HLA) (5-7). However, all three class II subregion products, namely HLA-DR, HLA-DP and HLA-DQ, have been detected on bile ducts in transplanted livers during rejection and other complications (5,8), in hepatic graft vs. host disease after bone marrow transplantation (9) and in PBC (4). It has been hypothesized that this expression is induced by soluble inflammatory mediators released from the invading mononuclear cells. Although the pathogenic role of this aberrant class II expression is unclear, we have previously shown that the increased destruction of bile duct epithelium during rejection is associated with HLA class II-specific lymphocytes invading the allograft (10). NIH Public Access Author ManuscriptHepatology. Author manuscript; available in PMC 2010 November 4. Published in final edited form as:Hepatology. 1991 February ; 13(2): 239-246. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author ManuscriptWe have established an in vitro model system to study the interactions between biliary epithelium and lymphocytes using cultured normal human biliary epithelial cells (BEC). The cultured BEC have been used to investigate the cytokines responsible for the up-regulation of class II MHC antigens and whether these MHC molecules were fu...

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“…Daar et al, 1984b). The so-called 'aberrant expression' of Class II products on normal epithelial cells is associated with immunological, inflammatory as well as hormonal stimuli (Klareskog et al, 1980;Lampert et al, 1981;Mason et al, 1981;Selby et al, 1983) and similar stimuli could promote their expression on malignant epithelial cells.…”

Section: Discussionmentioning

confidence: 99%

Expression of MHC products and leucocyte differentiation antigens in gynaecological neoplasms: An immunohistological analysis of the tumour cells and infiltrating leucocytes

Ferguson¹,

Moore²,

Fox³

1985

Br J Cancer

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The Detailed Distribution of MHC Class Ii Antigens in Normal Human Organs

Cited by 397 publications

References 0 publications

Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura.

Dendritic cells with antigen-presenting capability reside in airway epithelium, lung parenchyma, and visceral pleura.

Recognition of major histocompatibility complex antigens on cultured human biliary epithelial cells by alloreactive lymphocytes

Expression of MHC products and leucocyte differentiation antigens in gynaecological neoplasms: An immunohistological analysis of the tumour cells and infiltrating leucocytes

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