The design and synthesis of metallophthalocyanine–gold nanoparticle hybrids as biological agents

Farajzadeh, Nazli; Aftab, Javaria; Yenilmez, H. Yasemin; Özdemir, Sadin; Gonca, Serpil; Bayır, Zehra Altuntaş

doi:10.1039/d2nj00484d

Cited by 19 publications

(35 citation statements)

References 89 publications

(108 reference statements)

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“…The size of nanoparticles functionalized with phthalocyanines slightly increased as the π-π stacking between the modifying phthalocyanines led to H-aggregates 46,47 and the approach of adjacent nanoparticles (larger single or twinned particles). [48][49][50] The TEM images of NG and NG-3 are depicted in Fig. 2.…”

Section: Tem Analysismentioning

confidence: 99%

New phthalonitrile/metal phthalocyanine–gold nanoparticle conjugates for biological applications

et al. 2022

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Section: Tem Analysismentioning

confidence: 99%

New phthalonitrile/metal phthalocyanine–gold nanoparticle conjugates for biological applications

et al. 2022

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“…The antioxidant properties of phthalocyanine–gold nanoconjugates have been included in our previous studies for the first time. 49,50…”

Section: Introductionmentioning

confidence: 99%

The effect of phthalocyanine's periphery on the biological activities of carbazole-containing metal phthalocyanines

et al. 2023

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“…In recent years, many synthetic chlorins (Chl), porphyrins (Por), and Pcsporphyrinoids (second-generation PS) have been prepared, and some of them have been approved for use in the treatment of various types of cancer. Especially Pcs, one of the most important agents used as PSs, are used in PDT applications with their outstanding properties. − Their chemical structures are easily modified by the addition of peripheral, non-peripheral, and central metals and axial functional groups. − These modifications ensure easy regulation of the chemical and physical properties and biological distribution of Pcs. ,, …”

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confidence: 99%

Combination of Light and Ultrasound: Exploring Sono–Photochemical Activities of Phthalocyanine-Based Sensitizers

et al. 2023

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Recently, there has been increasing interest in photodynamic therapy (PDT) compared to traditional methods (immunotherapy, surgery, chemotherapy, or radiotherapy) in the treatment of cancer. Also, sonodynamic therapy (SDT) is a non-invasive therapeutic modality that enables high tissue penetration by triggered ultrasound (US). Phthalocyanines (Pcs) are known as one of the most important classes of sensitizers used in PDT and SDT. Motivated by these facts, in this study, to assess potentials for sono-PDT (SPDT), the preparation of peripherally substituted metal-free (2), zinc (3), and indium (4) Pcs was completed by 3-methoxybenzyloxy substituents. The resulting compounds were characterized by applying spectroscopic techniques including 1 H NMR, FT-IR, UV−vis, and MS. In sono−photochemical studies, the calculated singlet oxygen quantum yield (Φ Δ ) values were 0.68 for ZnPc (3) and 0.83 for InPc (4) after light irradiation; these values increased to 0.81 for 3 and 0.94 for 4 after combination US and light irradiation. The obtained data proved that the singlet oxygen production increased considerably by changing the method from light irradiation to US/light. This research will enrich the literature on increasing singlet oxygen production by the SPDT method. Theoretical calculations based on density functional theory (DFT) give further explanations of the optical and (photo)chemical processes behind the singlet oxygen generation. Our calculations are able to provide the energy of the excited states with excellent agreement with the experimental results, and they also allow us to understand and predict the activity of these Pcs based on their excited states and a clear enhancement of the spin−orbit coupling (SOC) when a metal center is included in the Pcs. This work thus exploits new insights into the advanced sono-photodynamic properties of potential sensitizers for efficient SPDT applications.

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The design and synthesis of metallophthalocyanine–gold nanoparticle hybrids as biological agents

Abstract: This study presents the synthesis of 4-2-(4-ethynyl-N,N-dimethylaniline)pthalonitrile (1) and its new peripherally tetra-substituted metal phthalocyanines {M= Co (2), Zn (3)}. Characterization of the prepared compounds was carried out by performing...

Cited by 19 publications

References 89 publications

New phthalonitrile/metal phthalocyanine–gold nanoparticle conjugates for biological applications

New phthalonitrile/metal phthalocyanine–gold nanoparticle conjugates for biological applications

The effect of phthalocyanine's periphery on the biological activities of carbazole-containing metal phthalocyanines

Combination of Light and Ultrasound: Exploring Sono–Photochemical Activities of Phthalocyanine-Based Sensitizers

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