“…3 There are historical reports of the use of barbiturates, amphetamines, neuroleptics, etcVall with no consistent benefit. 10,11 More recently, case reports of the effectiveness of antidepressants including selective serotonin reuptake inhibitors (SSRIs) 12 and a small controlled trial clomipramine 13 suggested some sporadic responsiveness. However, this initial promise has not been supported by a recent placebo-controlled, double-blind study of fluoxetine in 54 patients with DPD.…”
Section: Pharmacology Of Depersonalizationmentioning
The results of this trial suggest that a significant number of patients with DPD may respond to lamotrigine when combined with antidepressant medication. The results are sufficiently positive to prompt a larger controlled evaluation of lamotrigine as "add-on" treatment in DPD.
“…3 There are historical reports of the use of barbiturates, amphetamines, neuroleptics, etcVall with no consistent benefit. 10,11 More recently, case reports of the effectiveness of antidepressants including selective serotonin reuptake inhibitors (SSRIs) 12 and a small controlled trial clomipramine 13 suggested some sporadic responsiveness. However, this initial promise has not been supported by a recent placebo-controlled, double-blind study of fluoxetine in 54 patients with DPD.…”
Section: Pharmacology Of Depersonalizationmentioning
The results of this trial suggest that a significant number of patients with DPD may respond to lamotrigine when combined with antidepressant medication. The results are sufficiently positive to prompt a larger controlled evaluation of lamotrigine as "add-on" treatment in DPD.
“…I used to say ‘ we ’ rather than ‘ I ’. It is as though I had transcended personality, as if ‘myself’ had receded to an image which I regarded objectively, and which is not identified with the whole of me (Shorvon, , 784, emphasis mine)…”
Section: Pathological Self‐doubtmentioning
confidence: 99%
“…I must be someone, I am someone, everybody else feels someone, but I am not myself. I suddenly felt I am in half, there is two of me (Shorvon, , 782). I live as if I were double . .…”
Section: Pathological Self‐doubtmentioning
confidence: 99%
“…A subject is minimally rational if she masters the reflexive rule RR. Self‐doubters can justify their reluctance to use ‘I’ by appeal to the fact that their thoughts do not seem to have (i) a thinker, (ii) a unique thinker, (iii) or themselves for thinker (the patient of Shorvon's (, 784) quoted above is a particularly clear example, see also §7). This strongly suggests that they know that ‘I’ must refer to its thinker—that they master, that is, RR—and that this precisely why they feel uncomfortable using it.…”
Section: Self‐doubt and Rationalist Theoriesmentioning
Basic self‐awareness is the kind of self‐awareness reflected in our standard use of the first‐person. Patients suffering from severe forms of depersonalization often feel reluctant to use the first‐person and can even, in delusional cases, avoid it altogether, systematically referring to themselves in the third‐person. Even though it has been neglected since then, depersonalization has been extensively studied, more than a century ago, and used as probe for understanding the nature and the causal mechanisms of basic self‐awareness. In this paper, I argue that depersonalized patients indeed have an impaired basic self‐awareness, and that their study allows us both to favor one specific theory of basic self‐awareness and to understand what is wrong with its rivals. According to the favored theory, which I call Cartesian, we are basically self‐aware in virtue of being acquainted with ourselves through introspection.
“…… Everything around me is very far away and tiny. …" (Shovron, 1946), "I enter the house I lived in for the past 7 years and feel like I've never seen it before. … I look at my hand and it does not belong to me, it looks large and foreign.…" (PRMS).…”
Section: The Phenomenon Of Depersonalizationmentioning
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