2011
DOI: 10.1111/j.1369-1600.2010.00295.x
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Abstract: A major problem in treating alcohol use disorders (AUDs) is the high rate of relapse due to stress and re-exposure to cues or an environment previously associated with alcohol use. Stressors can induce relapse to alcohol seeking in humans or reinstatement in rodents. Delta opioid peptide receptors (DOP-Rs) play a role in cue-induced reinstatement of ethanol-seeking, however their role in stress-induced reinstatement of ethanol-seeking is not known. The objective of this study was to determine the role of DOP-R… Show more

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Cited by 31 publications
(39 citation statements)
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References 68 publications
(99 reference statements)
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“…Statistical analysis of inactive lever pressing using a twoway ANOVA revealed an overall effect of yohimbine dose (0 or 2 mg/kg) (F(1,47) ¼ 9.06, po0.01; Table 1), but no effect of pretreatment dose of mifepristone or interaction between mifepristone dose  yohimbine dose. Yohimbineinduced increases in inactive lever presses have been reported in the literature (Le et al, 2011;Marinelli et al, 2007); however, these effects are inconsistent as our group and others have failed to find such an effect (Le et al, 2005;Nielsen et al, 2011;Richards et al, 2008). More evidence of this inconsistency is offered in this study, where we show that inactive lever responding is increased only in the animals trained to respond for 10% ethanol, and not 20% ethanol or 5% sucrose.…”
Section: Effect Of Mifepristone On Yohimbine-induced Reinstatement Ofcontrasting
confidence: 39%
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“…Statistical analysis of inactive lever pressing using a twoway ANOVA revealed an overall effect of yohimbine dose (0 or 2 mg/kg) (F(1,47) ¼ 9.06, po0.01; Table 1), but no effect of pretreatment dose of mifepristone or interaction between mifepristone dose  yohimbine dose. Yohimbineinduced increases in inactive lever presses have been reported in the literature (Le et al, 2011;Marinelli et al, 2007); however, these effects are inconsistent as our group and others have failed to find such an effect (Le et al, 2005;Nielsen et al, 2011;Richards et al, 2008). More evidence of this inconsistency is offered in this study, where we show that inactive lever responding is increased only in the animals trained to respond for 10% ethanol, and not 20% ethanol or 5% sucrose.…”
Section: Effect Of Mifepristone On Yohimbine-induced Reinstatement Ofcontrasting
confidence: 39%
“…We have previously shown that animals trained to self-administer both 10 and 20% ethanol have an exaggerated CORT response to yohimbine when compared with sucrose controls . We have also shown that yohimbine treatment alters receptor signaling in the pooled midbrain (including the amygdala) of ethanol-experienced animals: changes that are not present in ethanol-naïve animals (Nielsen et al, 2011). Moreover, clinical evidence suggests that the cortisol response to yohimbine challenge in patients with a history of ethanol dependence is elevated compared with controls (Krystal et al, 1994(Krystal et al, , 1996.…”
Section: Discussionmentioning
confidence: 99%
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“…The administration of DOP-R antagonists decreases ethanol consumption and seeking in rats (Franck et al, 1998;Hyytia & Kiianmaa, 2001;June et al, 1999;Krishnan-Sarin et al, 1995b;Marinelli et al, 2009;Nielsen et al, 2011;Nielsen et al, 2008). However, DOP-R antagonists also have been shown to not affect (Ingman et al, 2003;Stromberg et al, 1998a) or increase ethanol intake (Margolis et al, 2008) (Table 1).…”
Section: Ethanol Consumption and Seeking With Dop-r Antagonistsmentioning
confidence: 99%
“…DOR activation was found to control inflammatory (4,5) as well as neuropathic pain (6,7) , treat/prevent migraine attacks (8) , enhance the analgesic potency of mu receptor agonists while reducing tolerance and dependence (9) , attenuate hyperalgesia (10) , modulate urinary bladder functions (11) and promote locomotion through differential signalling pathways (12) . On the other hand, DOR antagonists have been found to reduce alcohol seeking and abuse (13) . Moreover, DOR antagonists modulate gastrointestinal motility with mixed mu activation, which may serve as potential antidiarrheal agents in irritable bowel syndrome (14) .…”
Section: Introductionmentioning
confidence: 99%