The de Lange Syndrome

Ophthalmologic Findings in the Cornelia de Lange Syndrome

“…Synophrys is apparent in 85-100% of CdLS patients. 1,[2][3][4][5][6][7][8][13][14][15][16][17]19,[21][22][23][24][25] In the present study, we found synophrys to be present in 99% of the children. Only 4 children did not have this finding.…”

“…Many authors have been impressed by the long and curved eye lashes described in 7-100% of patients. 1,[2][3][4][5][6][7][15][16][17][20][21][22][25][26][27] In the present series, we found long lashes were present in 99% of the children. Only one child was noted not to have this finding.…”

“…[2][3][4][5][6][7]8,16,17,22 In our study 60% of the children had myopia. It has not been determined if the myopia is due to corneal, lenticular, or axial elements.…”

“…5,11 In a previous series, 26 59% of the patients in the group had blepharitis, chronic conjunctivitis, recurrent hordeolum, or nasolacrimal duct obstruction. In our current series, 25% of the patients examined suffered from blepharitis, 5.8% of the patients had a sty, 10% of the patients had a red lid margin, and 16% of the patients had history of nasolacrimal duct obstruction.…”

Medical Disorders with Associated Dermatoglyphic Abnormalities

“…(1969Pashayan et ai. ( , 1970, Passarge et al (1971), Payne and Maeda (1965), Pearce et al (1967), Podhradska et al (1968), Ptacek et al (1963), Richter (1961), Salazar (1966), Schlesinger et al (1963), Schuster and Johnson (1966), Silver (1964, Smithells (1965), Verma (1970), Vischer (1965), WaIbaum et al (1969), and our own unpublished data.…”