The Danish PET/depression project: Performance on Stroop's test linked to white matter lesions in the brain

Videbech, Poul; Ravnkilde, Barbara; Gammelgaard, Lise; Egander, A.; Clemmensen, Karin; Rasmussen, N. A.; Gjedde, Albert; Rosenberg, Raben

doi:10.1016/j.pscychresns.2003.10.002

Cited by 41 publications

(39 citation statements)

References 55 publications

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“…Impairments of selective attention in depression have been linked to white matter abnormalities (Videbech et al, 2004), but appear related to global slowing. The lack of impairment in CPT performance, and in reaction times to Word and Color conditions of the Stroop indicate that is not the case here.…”

Section: Discussionmentioning

confidence: 99%

Attention deficit in depressed suicide attempters

Keilp

Gorlyn

Oquendo

et al. 2008

Psychiatry Research

186

127

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Attention is typically impaired in depression and may play a role in risk for suicidal behavior. In this study, 66 non-patients, 83 depressed subjects with no past history of suicide attempt, 53 depressed subjects with one or more low lethality suicide attempts, and 42 depressed subjects with at least one high lethality attempt were compared on two computerized measures of attention, a Continuous Performance Test (CPT) and a Stroop task. All subjects were medication free at the time of assessment. Attention was impaired in all depressed subjects but worse in those with a past history of suicidal behavior. CPT performance did not differ among the groups, but Stroop interference was significantly poorer in all depressed subjects relative to non-patients, and poorer still in high lethality suicide attempters relative to all other groups. Interference score correlated modestly with subjective depression, functional level, suicide ideation, number of past suicide attempts, and lethality of past attempts. Depression-related impairments of attention, especially susceptibility to interference, are accentuated in those with a past history of suicidal behavior. Fundamental deficits in attention control may play a role in risk for suicidal behavior, and may contribute to a variety of cognitive deficits in suicidal patients. Brain mechanisms subserving attention control, which overlap considerably with regions implicated in affective disorders, may be a useful target for studies seeking to characterize neuropsychological factors associated with suicidal behavior.

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Section: Discussionmentioning

confidence: 99%

Attention deficit in depressed suicide attempters

Keilp

Gorlyn

Oquendo

et al. 2008

Psychiatry Research

186

127

View full text Add to dashboard Cite

show abstract

“…Limitations of MRI include the incompatibility of the procedure with intra-cranial or intra-abdominal metallic implants, devices, clips, and other monitoring equipment (e.g., pacemaker) (76,77). Moreover, the single unit of MRI resolution (1 mm 3 ) encompasses a large cell number (>10,000 neurons) rendering the detection of a smaller, yet clinically significant, cellular loss difficult.…”

Section: Evaluating the Hypothesis: Are Mood Disorders Associated Witmentioning

confidence: 99%

Neuroimaging Approaches in Mood Disorders: Technique and Clinical Implications

Konarski¹,

McIntyre²,

Soczynska³

et al. 2007

Annals of Clinical Psychiatry

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Advances in neuroimaging technology have refined models of disease pathophysiology in mood disorders and the mechanistic basis of antidepressant action. Multivariate analysis of functional and structural neuroimaging data, longitudinal analysis in the depressed and remitted states, and inclusion of representative patients with medical and psychiatric comorbidities will enhance the clinical translation of future research findings.

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“…Trotz der schlechteren Verhaltensleistungen wurden in dieser Studie weder in frontalen noch in subkortikalen Regionen funktionelle Unterschiede gefunden [94,93]. Eine beobachtete vermehrte frontale Aktivität im Verlauf der Erkrankung wurde als Zeichen der Kompensation und Anpassung an die bestehende Störung gedeutet.…”

Section: Tab 1 Befunde Bildgebender Studien Mit Spezifischen Neuropsunclassified

Exekutive Funktionen bei depressiven Patienten

Vasić

Walter

2007

Nervenarzt

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Depression is a multifarious disease, having an impact on most aspects of everyday life. Cognitive deficits cause considerable impairments and restraints in performance and have become one of the major clinical and research foci in recent years. According to previous work, deficits in executive functioning seem to be particularly prominent. At present only a few functional neuroimaging studies investigated the neurofunctional correlates aimed at these deficits by using specific activation tasks. These findings are somewhat controversial, revealing prefrontal hypo- as well as hyperactivation as a substrate of executive performance. This paper reviews current functional neuroimaging findings within a framework of depression as a dysfunction in limbic-cortical circuits. As a conclusion, the concept of "simple" hypofrontality does not offer a satisfactory explanation. Rather, a more dynamic model will be necessary in order to achieve a more realistic concept of executive deficits in depression.

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The Danish PET/depression project: Performance on Stroop's test linked to white matter lesions in the brain

Cited by 41 publications

References 55 publications

Attention deficit in depressed suicide attempters

Attention deficit in depressed suicide attempters

Neuroimaging Approaches in Mood Disorders: Technique and Clinical Implications

Exekutive Funktionen bei depressiven Patienten

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