The dangers of DNA vaccination

Dc, Górecki; Simons, Paul

doi:10.1038/5473

Cited by 10 publications

(10 citation statements)

References 5 publications

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“…While the DNA vaccine platform might have the potential to generate protective responses, the risk of random insertion mutagenesis resulting from integration in the host genome, anti-DNA antibody generation, and auto-immune diseases will remain [ 64 ].…”

Section: Major Covid-19 Vaccine Candidates and Their Responsesmentioning

confidence: 99%

COVID-19 Vaccines Currently under Preclinical and Clinical Studies, and Associated Antiviral Immune Response

et al. 2020

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With a death toll of over one million worldwide, the COVID-19 pandemic caused by SARS-CoV-2 has become the most devastating humanitarian catastrophe in recent decades. The fear of acquiring infection and spreading to vulnerable people has severely impacted society’s socio-economic status. To put an end to this growing number of infections and deaths as well as to switch from restricted to everyday living, an effective vaccine is desperately needed. As a result, enormous efforts have been made globally to develop numerous vaccine candidates in a matter of months. Currently, over 30 vaccine candidates are under assessment in clinical trials, with several undergoing preclinical studies. Here, we reviewed the major vaccine candidates based on the specific vaccine platform utilized to develop them. We also discussed the immune responses generated by these candidates in humans and preclinical models to determine vaccine safety, immunogenicity, and efficacy. Finally, immune responses induced in recovered COVID-19 patients and their possible vaccine development implications were also briefly reviewed.

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Section: Major Covid-19 Vaccine Candidates and Their Responsesmentioning

confidence: 99%

COVID-19 Vaccines Currently under Preclinical and Clinical Studies, and Associated Antiviral Immune Response

et al. 2020

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“…The use of the cytomegalovirus promoter/enhancer however may raise some safety concerns (Gorecki and Simons, 1999). These issues must be addressed particularly in light of recent evidence suggesting that injecting genes into muscle results in the uptake by motorneurones (Keir et al, 1995;Ribota et al, 1997).…”

Section: Immunisation Of Non Human Primates Against Carcinoembryonic mentioning

confidence: 97%

The Use Of Skeletal Muscle To Express Genes For The Treatment Of Cancer

Coe

Harron

Winslet

et al. 2002

Advances in Experimental Medicine and Biology

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“…Vaccine-specific safety concerns including thromboembolic events following the AstraZeneca [8] or Jansen COVID-19 vaccines [9], myocarditis or pericarditis following mRNA vaccines [10], and neurological manifestations (Bell's palsy or Guillain-Barrétype presentation) among others have been reported. The association of genomic information encoding vaccines with carcinogenesis is likely very low, especially with mRNA vaccines [11]. However, these concerns have not been more prevalent in immunocompromised or cancer patients, and the benefits of vaccination outweigh the concerns or these rare adverse effects [12].…”

Section: Safetymentioning

confidence: 99%

Cancer or COVID-19? A Review of Recommendations for COVID-19 Vaccination in Cancer Patients

Gundavda

2021

Curr. Treat. Options in Oncol.

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Opinion statement While emergency use is authorized for numerous COVID-19 vaccines and the high-risk population including cancer patients or those with immunosuppression due to disease or therapy is prioritized, data on this group’s specific safety and efficacy of these vaccines remains limited. Safety data from clinical trials and population data may be extrapolated, and these vaccines may be used for cancer patients. However, concerns of efficacy due to the variable immune response in patients with active cancers undergoing active therapy and cancer survivors with chronic immunosuppression remain. The authors aim to discuss the current recommendations for use of COVID-19 vaccination in patients with cancer.

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The dangers of DNA vaccination

Cited by 10 publications

References 5 publications

COVID-19 Vaccines Currently under Preclinical and Clinical Studies, and Associated Antiviral Immune Response

COVID-19 Vaccines Currently under Preclinical and Clinical Studies, and Associated Antiviral Immune Response

The Use Of Skeletal Muscle To Express Genes For The Treatment Of Cancer

Cancer or COVID-19? A Review of Recommendations for COVID-19 Vaccination in Cancer Patients

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