The daily gluten intake in relatives of patients with coeliac disease compared with that of the general Dutch population

vanOverbeek, FM; UilDieterman, Iga; Mol, IW; L, Köhler-Brands; Heymans, H. S. A.; Mulder, Cjj

doi:10.1097/00042737-199711000-00013

Cited by 106 publications

(78 citation statements)

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“…The daily intake of cereal containing gluten (wheat, rye, and barley) was assessed by means of a 24-hour dietary-recall questionnaire, and daily gluten intake was calculated as the sum of grams of protein obtained from gluten-related grains multiplied by 0.8. 16 A workup for celiac disease was performed at 15 Children with overt celiac disease began to receive a gluten-free diet, and those with potential celiac disease continued to receive a normal diet unless they had symptoms. Findings from the 2-year follow-up of a subgroup of children with potential celiac disease were reported in a previous study.…”

Section: Patients and Study Designmentioning

confidence: 99%

Introduction of Gluten, HLA Status, and the Risk of Celiac Disease in Children

Lionetti¹,

et al. 2014

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Section: Patients and Study Designmentioning

confidence: 99%

Introduction of Gluten, HLA Status, and the Risk of Celiac Disease in Children

Lionetti¹,

et al. 2014

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“…This was performed using food frequency questionnaires (FFQ) that were previously developed and validated in our population (23). The MDGI was calculated by multiplying the number of grams of vegetable proteins of each reported product by 0.8, according to a generally accepted method (25)(26)(27)(28). (29).…”

Section: Subjects and Study Designmentioning

confidence: 99%

Ten years of follow-up of the Spanish cohort of the European PreventCD study: the lessons learned

et al. 2018

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Aim: to evaluate the influence of gluten consumption on celiac disease development and to describe its natural history in the Spanish cohort of the European PreventCD study.Methods: prospective multi-center double blind study of 225 children that were followed up from birth. All cases were HLA-DQ2/HLA-DQ8 positive with a 1 st degree relative with celiac disease and were followed up in three centers from Madrid, Reus and Valencia. Gluten intake was determined between four and ten months according to the protocol. Gluten intake was ad libitum between eleven and 36 months and was prospectively quantified by means of dietary records. Clinical visits and specific antibody analysis for celiac disease were performed periodically. Results: twenty-six cases were diagnosed, all had a positive biopsy and serology; 21had gastrointestinal symptoms and five were asymptomatic. In addition, 2,565 food records were analyzed and statistically significant differences (p < 0.001) were found with regard to gluten consumption among the three centers, although not between celiac and non-celiac children (p = 0.025). The HLA-DQ2.5/DQ2.5 and DQ2.5/DQ2.2 genotypes had a relative risk of 4.7 (95% CI: 0.80-27.55; p = 0.08), which was higher than for the rest of genotypes. Female gender also had a relative risk that was five times higher than that for males.Conclusions: the amount of gluten intake between eleven and 36 months or the duration of breast feeding were not risk factors for the development of CD in the Spanish population. The HLA genotype and gender were the most relevant associated factors. In this at-risk group, the disease presented before two years of age in the majority of the cases with a weak clinical expression.

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“…The acceptable gluten dose per day is still under debate, although the scientific and medical communities have suggested that around 50 mg/day is safe (Hischenhuber et al, 2005). As a reference, the normal gluten intake by healthy individuals is about 13 g/day (Van Overbeek et al, 1997). Research indicates no significant differences in susceptible individuals undergoing a strict wheat starch-containing, gluten-free diet versus a naturally gluten-free diet (Kupper, 2005).…”

Section: Gliadins and The Celiac Diseasementioning

confidence: 99%