The Cyclopentolate Provocative Test in Suspected or Untreated Open‐angle Glaucoma

Abstract

Significant elevations of IOP, i. e. responses, occurred in eyes with suspected or untreated open-angle glaucoma during the mydriasis test with 1% cyclopentolate (CPT). The possible role of pigment in the IOP elevations seen in the responders was studied. Pigment was liberated in the aqueous, sometimes very profusely, in 88 (31.9%) of 276 eyes during CPT. The maximal IOP elevations, ad 20 mmHg, were seen in just these eyes. They were eyes with capsular or pigmentary glaucoma or eyes in which exceptionally heavy pigment was demonstrated in the chamber angle for other reasons. There was a statistically significant correlation between pigment liberation and IOP elevation during CPT. Evidently profuse pigment liberation may have caused transient blocking of the trabecular meshwork, obstruction of aqueous outflow and elevation of IOP. Liberation of pigment in the aqueous during CPT was statistically highly significantly more profuse in eyes with pseudoexfoliation than in eyes without pseudoexfoliation. An equally significant correlation with demonstrated between the grade of chamber angle pigmentation and the degree of pigment liberation during CPT. The significance of pigment for IOP elevation was seen also in the statistically highly significantly more profuse pigmentation of the chamber angle in the responder than in the non-responder eyes.

Diagnostic Uses of Common Eye Drops

“…Pigment liberation in the aqueous may also occur with cyclopentolate drops, indicating underlying pseudoexfoliation or pigment dispersion syndrome. 15 In this diagnostic “pigment dispersion test,” granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15…”

“…15 In this diagnostic “pigment dispersion test,” granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15…”

“…15 In this diagnostic ''pigment dispersion test,'' granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15 Another scenario whereby cyclopentolate instillation may yield diagnostic results is when patients present to their optometrist with advancing myopic refractive error. This may be the result of overstimulation of the eye's accommodative mechanism known as pseudomyopia.…”

“…Pigment liberation in the aqueous may also occur with cyclopentolate drops, indicating underlying pseudoexfoliation or pigment dispersion syndrome. 15 In this diagnostic ''pigment dispersion test,'' granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15 Another scenario whereby cyclopentolate instillation may yield diagnostic results is when patients present to their optometrist with advancing myopic refractive error.…”

Diagnostic Uses of Common Eye Drops

“…Pigment liberation in the aqueous may also occur with cyclopentolate drops, indicating underlying pseudoexfoliation or pigment dispersion syndrome. 15 In this diagnostic “pigment dispersion test,” granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15…”

“…15 In this diagnostic “pigment dispersion test,” granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15…”

“…15 In this diagnostic ''pigment dispersion test,'' granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15 Another scenario whereby cyclopentolate instillation may yield diagnostic results is when patients present to their optometrist with advancing myopic refractive error. This may be the result of overstimulation of the eye's accommodative mechanism known as pseudomyopia.…”

“…Pigment liberation in the aqueous may also occur with cyclopentolate drops, indicating underlying pseudoexfoliation or pigment dispersion syndrome. 15 In this diagnostic ''pigment dispersion test,'' granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15 Another scenario whereby cyclopentolate instillation may yield diagnostic results is when patients present to their optometrist with advancing myopic refractive error.…”

Diagnostic Uses of Common Eye Drops

“…Pigment liberation in the aqueous may also occur with cyclopentolate drops, indicating underlying pseudoexfoliation or pigment dispersion syndrome. 15 In this diagnostic “pigment dispersion test,” granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15…”

“…15 In this diagnostic “pigment dispersion test,” granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15…”

“…15 In this diagnostic ''pigment dispersion test,'' granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15 Another scenario whereby cyclopentolate instillation may yield diagnostic results is when patients present to their optometrist with advancing myopic refractive error. This may be the result of overstimulation of the eye's accommodative mechanism known as pseudomyopia.…”

“…Pigment liberation in the aqueous may also occur with cyclopentolate drops, indicating underlying pseudoexfoliation or pigment dispersion syndrome. 15 In this diagnostic ''pigment dispersion test,'' granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15 Another scenario whereby cyclopentolate instillation may yield diagnostic results is when patients present to their optometrist with advancing myopic refractive error.…”

Diagnostic Uses of Common Eye Drops

“…Pigment liberation in the aqueous may also occur with cyclopentolate drops, indicating underlying pseudoexfoliation or pigment dispersion syndrome. 15 In this diagnostic “pigment dispersion test,” granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15…”

“…15 In this diagnostic “pigment dispersion test,” granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15…”

“…15 In this diagnostic ''pigment dispersion test,'' granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15 Another scenario whereby cyclopentolate instillation may yield diagnostic results is when patients present to their optometrist with advancing myopic refractive error. This may be the result of overstimulation of the eye's accommodative mechanism known as pseudomyopia.…”

“…Pigment liberation in the aqueous may also occur with cyclopentolate drops, indicating underlying pseudoexfoliation or pigment dispersion syndrome. 15 In this diagnostic ''pigment dispersion test,'' granules are released from the iris pigment epithelium due to pupillary movement seen with irido-zonular or irido-lenticular contact. 15 Another scenario whereby cyclopentolate instillation may yield diagnostic results is when patients present to their optometrist with advancing myopic refractive error.…”