The cutaneous mucinoses

Reed, Richard J.; Clark, Wallace H.; Mihm, Martín C.

doi:10.1016/s0046-8177(73)80007-3

Cited by 37 publications

(14 citation statements)

References 22 publications

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“…There are also clinical indications that mast cells are involved in the pathogenesis of several forms of hair loss and alopecia in humans. In some forms of scarring alopecias (41,42) and in androgenetic alopecia (43), the number of skin mast cells is remarkably increased. These data support the notion that mast cells function as a hair cycle regulator and are involved in the control of hair follicle regression.…”

Section: Discussionmentioning

confidence: 99%

Human Chymase Expression in a Mice Induces Mild Hypertension with Left Ventricular Hypertrophy

et al. 2003

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Section: Discussionmentioning

confidence: 99%

Human Chymase Expression in a Mice Induces Mild Hypertension with Left Ventricular Hypertrophy

et al. 2003

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“…Dermal mucinosis is a frequent histological finding in both discoid lupus erythematosus (DLE) and systemic lupus erythematosus (SLE) (Prunieras & Montgomery, 1956;Reed, Clark & Mihm, 1973;Weigand, Burgdorf & Gregg, 1981), but rarely does it produce clinically apparent manifestations. A distinct papular eruption characterized by mucinous dermal deposits has been described by Gold (1954) in two SLE patients, and has since been confirmed in eight further reports.…”

mentioning

confidence: 99%

Papular and nodular mucinosis associated with systemic lupus erythematosus

Rongioletti

Rebora

1986

Br J Dermatol

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A patient is described in whom a papulo-nodular eruption occurred in association with systemic lupus erythematosus. Histopathology disclosed a diffuse deposition of mucin, mainly hyaluronic acid, in the dermis. This, and the 10 similar cases which have been reported in the literature, belong to a distinct clinico-pathological entity for which we propose the eponym of papular and nodular mucinosis of Gold, after the first observer to report it.

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“…Clinical studies have shown that mast cells are involved in the pathogenesis of various types of hair loss and alopecia. In scarring alopecia 12, 13 and androgenetic alopecia 14, the number of skin mast cells is remarkably increased. An increase in mast cells is potentially one of the reasons for remarkably higher chymase activity in skin than other organs, which may lead to alopecia in Tg mice.…”

Section: Discussionmentioning

confidence: 99%

Chymase Activities and Survival in Endotoxin-Induced Human Chymase Transgenic Mice

Rafiq¹,

Fan²,

Sherajee³

et al. 2014

Int. J. Med. Sci.

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We examined the effects of overexpressed human chymase on survival and activity in lipopolysaccharide (LPS)-treated mice. Human chymase transgenic (Tg) and wild-type C57BL/6 (WT) mice were treated with LPS (0.03, 0.1 and 0.3 mg/day; intraperitoneal) for 2 weeks. Treatment with 0.03 mg LPS did not affect survival in either WT or Tg mice. WT mice were not affected by 0.1 mg/day of LPS, whereas 25% of Tg mice died. Survival of mice treated with 0.3 mg/day of LPS was 87.5% and 0% in WT and Tg, respectively. LPS-induced increases in chymase activity in the heart and skin were significantly greater in Tg than WT mice. These data suggest a possible contribution of human chymase activation to LPS-induced mortality.

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The cutaneous mucinoses

Cited by 37 publications

References 22 publications

Human Chymase Expression in a Mice Induces Mild Hypertension with Left Ventricular Hypertrophy

Human Chymase Expression in a Mice Induces Mild Hypertension with Left Ventricular Hypertrophy

Papular and nodular mucinosis associated with systemic lupus erythematosus

Chymase Activities and Survival in Endotoxin-Induced Human Chymase Transgenic Mice

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