The cutaneous amyloidoses. I. Localized forms

Brownstein, Martin H.

doi:10.1001/archderm.102.1.8

Cited by 76 publications

(50 citation statements)

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“…Bence-Jones protein is detectable in the serum of all cases of systemic amyloidosis [4,6,16] and was not present in ours.…”

Section: Discussioncontrasting

confidence: 75%

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Primary Cutaneous Amyloidosis: Clinical, Laboratorial and Histopathological Study of 25 Cases

Habermann¹,

Montenegro²

1980

Dermatology

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25 cases of primary cutaneous amyloidosis are studied. 16 patients had macular amyloidosis (MPA) and 9 lichen amyloidosus (LPA). γ-Globulins were increased in 50% of the patients. IgG and IgA were increased in the serum of 5 and 3 patients with MPA and 4 and 2 patients with LPA, respectively. Volume of amyloid deposits was similar in both forms. By direct immunofluorescence we demonstrated IgG in the amyloid deposits of 21 of the 25 cases and C3 in 13; IgM was present in 9 cases of MPA and in 3 cases of LPA. MPA was more frequent than LPA; histologically, it was impossible to distinguish MPA from LPA; correlation between serum levels of γ-globulins and their presence in amyloid deposits was weak; MPA and LPA seem to be distinct clinical manifestations of the same disease and itching does not cause transformation of MPA in LPA.

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“…Bence-Jones protein is detectable in the serum of all cases of systemic amyloidosis [4,6,16] and was not present in ours.…”

Section: Discussioncontrasting

confidence: 75%

“…In our series and in the literature [2,4,8,24,30,36, 42] females with PA outnumber males and this fact is specially true for cases of MPA; our results, however, must be taken with caution since 54.5% of the patients registered in our dermatology outpatient service are females.…”

Section: Discussionsupporting

confidence: 56%

Primary Cutaneous Amyloidosis: Clinical, Laboratorial and Histopathological Study of 25 Cases

Habermann¹,

Montenegro²

1980

Dermatology

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“…Irregular acanthosis and increased granular layer was observed by Brownstein and Helwig et al in their study. 15 Amyloid deposition were however seen in the dermis as has been observed. The clue to final diagnosis and differentiation from other lesions rests in Apple green birefringence under polarised light on congo red staining.…”

mentioning

confidence: 66%

Clinicoepidemiological and histopathological study of cutaneous amyloidosis with histopathological correlation

Kilaparty

Maripati

2016

Int J Adv Med

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“…Progression of nodular amyloidosis to systemic amyloidosis has been reported to occur in 7% to 50% of patients. 2,3 Our goal was to review the clinical presentations of patients with nodular amyloidosis, examine these cases for evidence of plasma cell monoclonality, and obtain longterm follow-up data on progression to systemic disease. …”

Section: Resultsmentioning

confidence: 99%

“…3 He eventually developed biopsyproven amyloid nodules of the larynx with possible cardiac involvement as well. In a 1970 study by Brownstein and Helwig, 2 5 of 10 patients who initially appeared to have localized "tumefactive" or nodular amyloidosis were subsequently found to have evidence of systemic amyloidosis. Unfortunately, no details regarding initial laboratory investigations or follow-up periods were provided.…”

mentioning

confidence: 99%