The current profile and outcome of congenital diaphragmatic hernia: A nationwide survey in Japan

The use of human amniotic fluid stem cells as an adjunct to promote pulmonary development in a rabbit model for congenital diaphragmatic hernia

“…At birth, this leads to respiratory insufficiency and persistent pulmonary hypertension (PHT) . Despite prenatal referral to high volume centers offering standardized neonatal care survival rates are around 60–70% …”

Surgical approaches for neonatal congenital diaphragmatic hernia: a systematic review and meta-analysis

“…Although survival in cases of CDH has improved during the past decades, the treatment of severe cases remains challenging, and a considerable number of survivors experience long-term morbidity [2,3].…”

Prognostic factors of gastroesophageal reflux disease in congenital diaphragmatic hernia: a multicenter study

“…Although the rate of GERD in CDH patients varies according to study designs, nearly 40 % of CDH survivors are thought to have symptomatic GERD, and half of them require antireflux surgery [1]. Meanwhile, some reports have revealed that natural history of GERD associated with CDH has the tendency to resolve without surgery, as well as isolated GERD [9,14,15]. In this study, 11 % of total cases underwent surgery by the age of 2 years, while 60 % of patients who had medical therapies for GERD completed it by the age of 3 years.…”

“…This study was subsequent of a nationwide survey of neonatal CDH conducted by The Japanese Congenital Diaphragmatic Hernia Study Group in 2011 [15]. The subject of this retrospective cohort study was 674 CDH patients who were born between January 2006 and December 2010 in 109 institutions.…”