2008
DOI: 10.1074/jbc.m805643200
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Abstract: Sulfate reduction is one of the earliest types of energy metabolism used by ancestral organisms to sustain life. Despite extensive studies, many questions remain about the way respiratory sulfate reduction is associated with energy conservation. A crucial enzyme in this process is the dissimilatory sulfite reductase (dSiR), which contains a unique siroheme-[4Fe4S] coupled cofactor. Here, we report the structure of desulfoviridin from Desulfovibrio vulgaris, in which the dSiR DsrAB (sulfite reductase) subunits … Show more

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Cited by 150 publications
(233 citation statements)
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References 57 publications
(92 reference statements)
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“…DsrC in its persulfidic state appears to be very stable as we did not detect any reverse transfer reaction from DsrC to TusA or DsrEFH. Persulfurated DsrC very probably serves as a direct substrate for DsrAB in vivo (4,44), and it is, therefore, feasible that DsrC acts as a sulfur trap. This would ensure a constant flow of sulfur atoms necessary for a high turnover rate of DsrAB.…”
Section: Discussionmentioning
confidence: 99%
“…DsrC in its persulfidic state appears to be very stable as we did not detect any reverse transfer reaction from DsrC to TusA or DsrEFH. Persulfurated DsrC very probably serves as a direct substrate for DsrAB in vivo (4,44), and it is, therefore, feasible that DsrC acts as a sulfur trap. This would ensure a constant flow of sulfur atoms necessary for a high turnover rate of DsrAB.…”
Section: Discussionmentioning
confidence: 99%
“…Six electron-transfer reactions are rare in nature. The few examples are the reverse-acting sulfite reductase rDsrAB containing various [4Fe4S] centers (15) and the pentaheme cytochrome c nitrite reductase (16).…”
Section: The Atomic Coordinates and Structure Factors (Code 2xts) Havmentioning
confidence: 99%
“…Two membrane complexes that were identified in the D. gigas genome, the Qmo and Dsr complexes, were proposed to perform this function (21,36). An energy conservation process may result from electron transfer from the quinone pool to AprAB through the Qmo complex (19,37), and also the Dsr complex may be involved in menaquinol oxidation with reduction of DsrC, associated with proton translocation (36,38). Furthermore, other electron transfer pathways to sulfate may involve Hdr-related proteins that could provide a soluble pathway from different donors (such as lactate, pyruvate, ferredoxin, or H 2 ) to the reduction of DsrC in a flavin-based electron bifurcation mechanism for energy conservation (6).…”
Section: Discussionmentioning
confidence: 99%