The crab, the turkey and a malignant tale from the year of the rooster

Reuben, Adrian

doi:10.1002/hep.20674

Cited by 7 publications

(8 citation statements)

References 41 publications

(40 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This increased incidence is attributed to viral hepatitis and carcinogenic toxins such as aflatoxin [2]. Alpha fetoprotein (AFP), one of the tumor markers used for diagnostic purposes in hepatocellular carcinoma (HCC), is limited in its diagnostic utility because 50% (35% in Johns Hopkins Hospital [3]) of the patients with HCC do not show high level of AFP [4–6].…”

Section: Introductionmentioning

confidence: 99%

18O Labeling for a Quantitative Proteomic Analysis of Glycoproteins in Hepatocellular Carcinoma

et al. 2008

View full text Add to dashboard Cite

Introduction Quantitative proteomics using tandem mass spectrometry is an attractive approach for identification of potential cancer biomarkers. Fractionation of complex tissue samples into subproteomes prior to mass spectrometric analyses increases the likelihood of identifying cancer-specific proteins that might be present in low abundance. In this regard, glycosylated proteins are an interesting class of proteins that are already established as biomarkers for several cancers. Materials and Methods In this study, we carried out proteomic profiling of tumor and adjacent non-cancer liver tissues from hepatocellular carcinoma (HCC) patients. Glycoprotein enrichment from liver samples using lectin affinity chromatography and subsequent 18O/16O labeling of peptides allowed us to obtain relative abundance levels of lectin-bound proteins. As a complementary approach, we also examined the relative expression of proteins in HCC without glycoprotein enrichment. Lectin affinity enrichment was found to be advantageous to quantitate several interesting proteins, which were not detected in the whole proteome screening approach. We identified and quantitated over 200 proteins from the lectin-based approach. Interesting among these were fetuin, cysteine-rich protein 1, serpin peptidase inhibitor, leucine-rich alpha-2-glycoprotein 1, melanoma cell adhesion molecule, and heparan sulfate proteoglycan-2. Using lectin affinity followed by PNGase F digestion coupled to 18O labeling, we identified 34 glycosylation sites with consensus sequence N-X-T/S. Western blotting and immunohistochemical staining were carried out for several proteins to confirm mass spectrometry results. Conclusion This study indicates that quantitative proteomic profiling of tumor tissue versus non-cancerous tissue is a promising approach for the identification of potential biomarkers for HCC.

show abstract

Section: Introductionmentioning

confidence: 99%

18O Labeling for a Quantitative Proteomic Analysis of Glycoproteins in Hepatocellular Carcinoma

et al. 2008

View full text Add to dashboard Cite

show abstract

“…The aflatoxin story 37 that had the potential for unraveling the molecular pathogenesis of HCC generally did not live up to expectations 38 . Aflatoxins, the bisfuranocoumarin mycotoxin products of the Aspergillus flavus and parasiticus molds that contaminate peanuts, soybeans, grains, and cassava root in tropical areas, are indeed potent carcinogens in animals via some of their metabolites, and this includes hepatocarcinogenesis in rodents, nonrodent species, and nonhuman primates 39 .…”

Section: Figurementioning

confidence: 99%

“…Taiwan's mass vaccination program against HBV An Official Learning Resource of AASLD Historical Perspective of HCC Risk Factors Natarajan and El-Serag review was launched in 1984, and Prof. Mei-Hwei Chang and his group reported in a landmark article that the incidence and mortality rates for liver cancer declined in successive birth cohort generations between 1981 and 1994 of children 6 to 14 years of age in Taiwan. 36 The aflatoxin story 37 that had the potential for unraveling the molecular pathogenesis of HCC generally did not live up to expectations. 38 Aflatoxins, the bisfuranocoumarin mycotoxin products of the Aspergillus flavus and parasiticus molds that contaminate peanuts, soybeans, grains, and cassava root in tropical areas, are indeed potent carcinogens in animals via some of their metabolites, and this includes hepatocarcinogenesis in rodents, nonrodent species, and nonhuman primates.…”

mentioning

confidence: 99%

Risk Factors for Hepatocellular Carcinoma: A Historical Perspective

Natarajan

El–Serag

2021

Clinical Liver Disease

View full text Add to dashboard Cite

“…216 CE). Galen gave an extensive description of the crab-like nature upon examining an advanced stage of breast cancer, 8 expressly commenting, -In the breasts we often find a tumour in size and shape closely resembling the animal known as a crab, for as in the latter the limbs protrude from either side, so in the tumour the swollen veins radiate from its edges and give a perfect picture of the crab.‖ 9 And more vividly by stating: -it appears at length with turgid veins shooting out from it, so as to resemble the figure of a crab; or as others say, because like a crab, where once it has got, it is scarcely possible to drive it away.‖ 10 With the emergence of English as the lingua franca of science, the analogy was universally appreciated and the name was retained. An English physician Peter Lowe in 1579 went so far as to describe the invasive and crab-likeness by saying that they -gnaweth, eateth and goeth like this fish.‖ 11 But the English-speaking people could not decide for centuries which terminology to adopt; cancer, cancre, chancre, and kanker, all from the same etymology, were indiscriminately applied.…”

Section: It's All Greekmentioning

confidence: 99%

The making of oncology: The tales of false carcinogenic worms

Lalchhandama¹

2017

Sci Vis

View full text Add to dashboard Cite

Cancer is a disease of antiquity. The Ancient Greeks were familiar with onkos (from which we have the term oncology)—tumour of all sorts. Hippocrates coined karkinos and karkinoma, our source of the words cancer and carcinoma. Of a plethora of carcinogens, parasitic worms (helminths) constitute a considerable health concern. Three trematodes, Clonorchis sinensis, Opisthorchis viverrini, and Schistosoma haematobium are now officially classified carcinogens. But the discovery of helminths as cancer-causing agents took wrong turns and marks an inglorious chapter in the history of science. The carcinogenicity of worms, vindicating Rudolf Virchow’s reiztheorie (irritation theory) of cancer origin, was glorified in the scientific forefront by Johannes Fibiger in the 1910s. Discovery of a new nematode, which he proudly named Spiroptera carcinoma, and his subsequent demonstration that the parasite could induce stomach cancer in rats, earned Fibiger a retrospective Nobel Prize in Physiology or Medicine in 1926, and a lasting fame. But not in an appealing way. His achievement did not withstand the test of time. S. carcinoma was annulled as an invalid taxon in zoology—supplanted by Gongylonema neoplasticum—and eventually was branded as a non-carcinogenic agent.

show abstract

The crab, the turkey and a malignant tale from the year of the rooster

Cited by 7 publications

References 41 publications

18O Labeling for a Quantitative Proteomic Analysis of Glycoproteins in Hepatocellular Carcinoma

18O Labeling for a Quantitative Proteomic Analysis of Glycoproteins in Hepatocellular Carcinoma

Risk Factors for Hepatocellular Carcinoma: A Historical Perspective

The making of oncology: The tales of false carcinogenic worms

Contact Info

Product

Resources

About