The cost-effectiveness of predonation screening for transfusion transmissible infections using rapid test kits in a hospital-based blood transfusion centre

Dosunmu, Adedoyin; Akinbami, Akinsegun; Ismail, Ayobami; Olaiya, M. A.; Uche, Ebele; Aile, Igbinoba Kingsley

doi:10.4103/npmj.npmj_33_17

Cited by 4 publications

(3 citation statements)

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“…The program was found to be highly cost-effective, with an ICER of US$540 per DALY averted compared to status quo where no publicly provided HBV screening or treatment was available. Integrating low-cost HBV POCs into existed healthcare services such as antenatal screening [ 52 , 58 , 107 ], blood donor screening [ 62 ] and HIV clinics [ 59 , 60 , 61 ] can be another solution to achieve scale-up of HBV testing [ 108 , 109 ]. Zhang et al [ 109 ] showed the integration of HBV screening within the existing antenatal care in Cambodia was highly cost-effective.…”

Section: Cost-effectiveness Of Using Pocs For Hepatitis Bmentioning

confidence: 99%

Point-of-Care Tests for Hepatitis B: An Overview

Xiao

Thompson

Howell

2020

Cells

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Despite the heavy disease burden posed by hepatitis B, around 90% of people living with hepatitis B are not diagnosed globally. Many of the affected populations still have limited or no access to essential blood tests for hepatitis B. Compared to conventional blood tests which heavily rely on centralised laboratory facilities, point-of-care testing for hepatitis B has the potential to broaden testing access in low-resource settings and to engage hard-to-reach populations. Few hepatitis B point-of-care tests have been ratified for clinical use by international and regional regulatory bodies, and countries have been slow to adopt point-of-care testing into hepatitis B programs. This review presents currently available point-of-care tests for hepatitis B and their roles in the care cascade, reviewing evidence for testing performance, utility, acceptability, costs and cost-effectiveness when integrated into hepatitis B diagnosis and monitoring programs. We further discuss challenges and future directions in aspects of technology, implementation, and regulation when adopting point-of-care testing in hepatitis B programs.

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Section: Cost-effectiveness Of Using Pocs For Hepatitis Bmentioning

confidence: 99%

Point-of-Care Tests for Hepatitis B: An Overview

Xiao

Thompson

Howell

2020

Cells

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“…[53][54][55] Secondly, financial constraints and the cost of blood transfusion are some of the reasons in the literature to explain why there is a lack of predonation screening for the DENV. 56,57 As shown in this review, very minimal research activities were observed in the African region regardless of the presence of dengue on the continent. A similar observation has also been made in a limited number of epidemiological research activities on the continent.…”

Section: Global Distributions Of Research Work Around the Dengue Viru...mentioning

confidence: 87%

Dengue Virus and Blood Safety: A Mini-Review of Research Publications

Mulakoli

Gachara

Ndombi

et al. 2023

EASci

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The growing demand for donated whole blood and blood products to save lives has both health benefits and health risks for blood recipients at the same time. Dengue virus, a re-emerging viral disease poses a threat to blood safety, and it has spread to over 128 countries in the world. Several studies have documented transfusion-transmitted (TT) dengue, with the first cases being reported in China in 2002 and Singapore in 2008. To understand the magnitude and broader picture of the dengue virus and blood safety, we conducted a mini-review of published literature from the Scopus database. The review focused on the number of publications related to the dengue virus among blood donors. Using keywords ‘Dengue virus’ AND ‘Blood safety’, ‘ Dengue virus’ AND ‘Blood donors’ and ‘Emerging infectious diseases’ AND “Blood safety” were used to extract data from the Scopus database which was downloaded as a CSV Excel file covering a period 2004 to 2021. This was followed by a data-cleaning exercise and a descriptive analysis to generate the frequency of the number of publications. Most studies, as can be seen in the review, were concentrated in tropical regions of the world. Globally, South America and the Asian regions had the largest number of publications; while at the country level, Brazil and India had the highest number. More research output was witnessed during the years 2014 and 2018. The regions that experienced more frequent outbreaks of the disease, with the exception Africa, published most of the research work. Therefore, much more research work is needed to protect the safety of blood donors in Africa.

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“…In summary, despite that good cost effectiveness of PDT is reported in high transfusion‐transmissible infection (TTI) prevalence settings in Africa [31], the cost effectiveness in low HIV prevalence settings is still to be assessed. Moreover, stigmatization after HIV donor notification immediately after the donor testing may limit the acceptability of the PDT by benevolent donors and impact on regular blood donation.…”

Section: Discussionmentioning

confidence: 99%

Implementation of an Africa‐specific donor health questionnaire for human immunodeficiency virus risk screening

et al. 2022

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Background and Objectives: We had previously developed an Africa-specific donor health questionnaire (ASDHQ) based on local risk factors and designed a scoring scheme. This study assessed the performance of a new donor health questionnaire by comparing the human immunodeficiency virus (HIV) status in accepted versus deferred donors by ASDHQ and comparing the rate of risk deferrals with historical data. Materials and Methods: Data were collected during a cross-sectional study conducted over 15 months at three referral-hospital-based blood services in Cameroon. ASDHQ was administered to blood donors aged 18-65 years in the same screening conditions as the routine questionnaire. The main outcomes of the study were ASDHQ sensitivity and specificity with regard to HIV laboratory testing as well as donor deferral rates for each of the routine screening algorithms and for ASDHQ.Results: Overall, 71/11,120 (0.6%) were confirmed as HIV positive. The mean ASDHQ score was 95.80 AE 4.4 in HIV-negative donors and 94.80 AE 4.4 in HIV-positive donors (p = 0.05). The optimal cut-off provided by the receiver operating characteristic (ROC) curve for the best performance of ASDHQ was 95.04. Using this optimal cut-off, the ASDHQ sensitivity and specificity were 57% and 53%, respectively (area under curve = 0.58 [0.51, 0.64], p = 0.028).

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The cost-effectiveness of predonation screening for transfusion transmissible infections using rapid test kits in a hospital-based blood transfusion centre

Abstract: This analysis demonstrated that with proper donor selection, rapid screening for hepatitis B virus only before ELISA screening is more cost-effective. This will also reduce the waiting time for donors and counselling if HIV positive.

Cited by 4 publications

References 0 publications

Point-of-Care Tests for Hepatitis B: An Overview

Point-of-Care Tests for Hepatitis B: An Overview

Dengue Virus and Blood Safety: A Mini-Review of Research Publications

Implementation of an Africa‐specific donor health questionnaire for human immunodeficiency virus risk screening

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