The Corticostriatal Adenosine A2A Receptor Controls Maintenance and Retrieval of Spatial Working Memory

Li, Zhihui; Chen, Xingjun; Wang, Tao; Gao, Ying; Li, Fēi; Chen, Long; Xue, Junmin; He, Yan; Li, Yan; Guo, Wei; Zheng, Wu; Zhang, Liping; Ye, Fenfen; Ren, Xiaojun; Yue, Feng; Chan, Piu; Chen, Jiang‐Fan

doi:10.1016/j.biopsych.2017.07.017

Cited by 43 publications

(36 citation statements)

References 71 publications

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“…; Li et al . ), rather than requiring the engagement of A 2A R controlling either the release of dopamine (Gomes et al . ) or the function of D 2 R in MSNs (Ferré et al .…”

Section: Discussionmentioning

confidence: 99%

“…In line with this, working memory is well established to be bolstered upon A 2A R blockade (Zhou et al 2009;Augusto et al 2013) and decreased upon A 2A R over-expression (Gimenez-Llort et al 2007). This effect would directly depend on A 2A R located at corticostriatal synapses (Wei et al 2011;Li et al 2018), rather than requiring the engagement of A 2A R controlling either the release of dopamine (Gomes et al 2009) or the function of D 2 R in MSNs (Ferr e et al 2008). The repeated stimulation of A 2A R also triggers a locomotor sensitization similar to that caused by low doses of caffeine (Tronci et al 2006;Hsu et al 2009), although caffeine also sensitizes cortical A 1 R (Green and Stiles 1986).…”

Section: Discussionmentioning

confidence: 99%

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Chronic adenosine A_2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37‐deficient mice

Morató

Gonçalves

Lopes

et al. 2019

Journal of Neurochemistry

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Adenosine A2A receptors (A2AR) play a key role in modulating dopamine‐dependent locomotor activity, as heralded by the sensitization of locomotor activity upon chronic A2AR blockade, which is associated with elevated dopamine levels and altered corticostriatal synaptic plasticity. Since the orphan receptor GPR37 has been shown to modulate A2AR function in vivo, we aimed to test whether the A2AR‐mediated sensitization of locomotor activity is GPR37‐dependent and involves adaptations of synaptic plasticity. To this end, we administered a selective A2AR antagonist, SCH58261 (1 mg/kg, i.p.), daily for 14 days, and the locomotor sensitization, striatum‐dependent cued learning, and corticostriatal synaptic plasticity (i.e., long‐term depression) were compared in wild‐type and GPR37−/− mice. Notably, GPR37 deletion promoted A2AR‐associated locomotor sensitization but not striatum‐dependent cued learning revealed upon chronic SCH58261 treatment of mice. Furthermore, chronic A2AR blockade potentiated striatal long‐term depression in corticostriatal synapses of GPR37−/− but not of wild‐type mice, thus correlating well with neurochemical alterations of the adenosinergic system. Overall, these results revealed the importance of GPR37 regulating A2AR‐dependent locomotor sensitization and synaptic plasticity in the basal ganglia circuitry. Open science badges This article has received a badge for *Open Materials* because it provided all relevant information to reproduce the study in the manuscript. The complete Open Science Disclosure form for this article can be found at the end of the article. More information about the Open Practices badges can be found at https://cos.io/our-services/open-science-badges/. Open Science: This manuscript was awarded with the Open Materials Badge. For more information see: https://cos.io/our-services/open-science-badges/

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“…; Li et al . ), rather than requiring the engagement of A 2A R controlling either the release of dopamine (Gomes et al . ) or the function of D 2 R in MSNs (Ferré et al .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chronic adenosine A_2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37‐deficient mice

Morató

Gonçalves

Lopes

et al. 2019

Journal of Neurochemistry

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“…Furthermore, cognitive control and working memory processes are important for the efficient control of goal-directed behavior ( Buschman and Miller, 2014 ). We and others have documented that the A 2A R antagonists or focal A 2A R knockdown in the DMS significantly enhance working memory ( Wei et al, 2014 ; Kaster et al, 2015 ; Li et al, 2018 ). Thus, it is possible that when KW6002 is administered prior to the training phase, the A 2A R antagonist may enhance goal-directed behavior by improving working memory.…”

Section: Discussionmentioning

confidence: 81%

Pharmacological Blockade of Adenosine A2A but Not A1 Receptors Enhances Goal-Directed Valuation in Satiety-Based Instrumental Behavior

Pan

et al. 2018

Front. Pharmacol.

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The balance and smooth shift between flexible, goal-directed behaviors and repetitive, habitual actions are critical to optimal performance of behavioral tasks. The striatum plays an essential role in control of goal-directed versus habitual behaviors through a rich interplay of the numerous neurotransmitters and neuromodulators to modify the input, processing and output functions of the striatum. The adenosine receptors (namely A2AR and A1R), with their high expression pattern in the striatum and abilities to interact and integrate dopamine, glutamate and cannabinoid signals in the striatum, may represent novel therapeutic targets for modulating instrumental behavior. In this study, we examined the effects of pharmacological blockade of the A2ARs and A1Rs on goal-directed versus habitual behaviors in different information processing phases of instrumental learning using a satiety-based instrumental behavior procedure. We found that A2AR antagonist acts at the coding, consolidation and expression phases of instrumental learning to modulate animals’ sensitivity to goal-directed valuation without modifying action-outcome contingency. However, pharmacological blockade and genetic knockout of A1Rs did not affect acquisition or sensitivity to goal-valuation of instrumental behavior. These findings provide pharmacological evidence for a potential therapeutic strategy to control abnormal instrumental behaviors associated with drug addiction and obsessive-compulsive disorder by targeting the A2AR.

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“…In the striatum, increased c-Fos mRNA levels were detected in the DlS under the 24s delay conditions, but not in the DmS or NAc. The lack of c-Fos changes in the DmS was somewhat surprising, as prior studies have indicated the involvement of this brain region in controlling the choice accuracy in operant and T-maze-based delayed non-match to position (DNMTP) tasks (Akhlaghpour et al 2016;Li et al 2018). It should be noted that our results do not rule out the role for cortico-striatal projections in WM performance; instead, they suggest that The midline thalamic nucleus termed the NRe has been assigned the role of an important brain structure supporting reciprocal hippocampal-mPFC communication.…”

Section: Discussionmentioning

confidence: 99%

Using rat operant delayed match-to-sample task to identify neural substrates recruited with increased working memory load

Gobin

Schwendt

2020

Preprint

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The delayed match-to-sample task (DMS) is used to probe working memory (WM) across species. While the involvement of the PFC in this task has been established, limited information exists regarding the recruitment of broader circuitry, especially under the low-versus high-WM load. We sought to address this question by using a variable-delay operant DMS task. Male Sprague-Dawley rats were trained and tested to determine their baseline WM performance across all (0-24s) delays. Next, rats were tested in a single DMS test with either 0s or 24s fixed delay, to assess low-/high-load WM performance. c-Fos mRNA expression was quantified within cortical and subcortical regions and correlated with WM performance. High WM load upregulated overall c-Fos mRNA expression within the PrL, as well as within a subset of mGlu5+ cells, with load-dependent, local activation of protein kinase C as the proposed underlying molecular mechanism. The PrL activity negatively correlated with choice accuracy during high load WM performance. A broader circuitry, including several subcortical regions, was found to be activated under low and/or high load conditions. These findings highlight the role of mGlu5 and/or PKC dependent signaling within the PrL, and corresponding recruitment of subcortical regions during highload WM performance.

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The Corticostriatal Adenosine A2A Receptor Controls Maintenance and Retrieval of Spatial Working Memory

Cited by 43 publications

References 71 publications

Chronic adenosine A_2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37‐deficient mice

Chronic adenosine A_2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37‐deficient mice

Pharmacological Blockade of Adenosine A2A but Not A1 Receptors Enhances Goal-Directed Valuation in Satiety-Based Instrumental Behavior

Using rat operant delayed match-to-sample task to identify neural substrates recruited with increased working memory load

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The Corticostriatal Adenosine A2A Receptor Controls Maintenance and Retrieval of Spatial Working Memory

Cited by 43 publications

References 71 publications

Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37‐deficient mice

Chronic adenosine A2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37‐deficient mice

Pharmacological Blockade of Adenosine A2A but Not A1 Receptors Enhances Goal-Directed Valuation in Satiety-Based Instrumental Behavior

Using rat operant delayed match-to-sample task to identify neural substrates recruited with increased working memory load

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Chronic adenosine A_2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37‐deficient mice

Chronic adenosine A_2A receptor blockade induces locomotor sensitization and potentiates striatal LTD IN GPR37‐deficient mice