2018
DOI: 10.18632/aging.101461
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Abstract: Copy number variations (CNVs) have been shown to cause numerous diseases, however, their roles in human lifespan remain elusive. In this study, we investigate the association of CNVs with longevity by comparing the Han Chinese genomes of long-lived individuals from 90 to 117 years of age and the middle-aged from 30 to 65. Our data demonstrate that the numbers of CNVs, especially deletions, increase significantly in a direct correlation with longevity. We identify eleven CNVs that strongly associate with longev… Show more

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Cited by 21 publications
(10 citation statements)
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References 42 publications
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“…Large-scale distension or “unraveling” of peri/centromeric satellites occurs in all examined models of human and mouse senescence (Enukashvily et al, 2007; Swanson et al, 2013). Some results indicate that satellite CNVs contribute to the genetic component of human longevity (Sidler et al, 2014; Nygaard et al, 2016; Zhao et al, 2018). Although whole-genome sequencing may help to identify CNVs, most analytical methods suffer from limited capacity, especially in low-mappability regions (Monlong et al, 2018).…”
Section: Introductionmentioning
confidence: 99%
“…Large-scale distension or “unraveling” of peri/centromeric satellites occurs in all examined models of human and mouse senescence (Enukashvily et al, 2007; Swanson et al, 2013). Some results indicate that satellite CNVs contribute to the genetic component of human longevity (Sidler et al, 2014; Nygaard et al, 2016; Zhao et al, 2018). Although whole-genome sequencing may help to identify CNVs, most analytical methods suffer from limited capacity, especially in low-mappability regions (Monlong et al, 2018).…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, mortality is increased in individuals with pathologic excess of GH ( Baumann, 1987 ). Studies of the genetic polymorphism of candidate genes, genome-wide association studies (GWAs), and analysis of signaling pathways, genetic networks, and copy number variations, provided evidence that human aging is influenced by genes related to the somatotropic axis ( van Heemst et al, 2005 ; Suh et al, 2008 ; Bonafe and Olivieri, 2009 ; Dato et al, 2018 ) and its downstream targets including FOXO3A ( Blankenburg et al, 2018 ; Revelas et al, 2018 ; Zhao et al, 2018 ).…”
Section: Introductionmentioning
confidence: 99%
“…Sampling, population quality, and genotyping on the cohort have been reported 23‐25 . Samples and data from the CLHLS were randomly selected from half of the counties and cities in 22 of the 31 provinces in China, which means the data cover approximately 85% of the total Chinese population.…”
Section: Methodsmentioning
confidence: 99%
“…In order to search for factors that influence healthy aging and longevity, we initiated the Chinese Longitudinal Healthy Longevity Survey (CLHLS) in a large Chinese cohort from 1998 to 2014 and carried out genetic screening, leading to the identification of a number of genes associated with human longevity. [21][22][23][24] Among these studies, datasets of the genome-wide association study that included 2178 centenarians and 2299 middle-aged controls 23,24 were subjected to searches for the genetic associations of the ABO gene and blood groups with longevity.…”
Section: Ta B L E 1 the Frequencies Of Abo Allelesmentioning
confidence: 99%
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