The Correlation between Serum Sclerostin Level and Arterial Stiffness in Peritoneal Dialysis Patients

Abstract

Objective. To study the correlation between serum sclerostin (SO) and arterial stiffness in peritoneal dialysis (PD) patients. Methods. The study included 50 Parkinson’s disease (PD) patients on continuous ambulatory peritoneal dialysis (CAPD) for more than 6 months at the nephrology department of our hospital. Without regard for age, the eligible patients were assigned to a low PWV group and a high PWV group with brachial-ankle pulse wave velocity (Ba PWV) of 1400 cm/s as the cutoff value. Patient characteristics such as age, gender, height, weight, BMI, smoking history, dialysis age, systolic blood pressure (SBP), diastolic blood pressure (DBP), urea clearance index (Kt/V), residual renal function (RRF), and diabetes mellitus (DM) were analyzed. Biochemical indices for analysis include hemoglobin (Hb), albumin (ALB), total cholesterol (TC), urea nitrogen (BUN), creatinine (CREA), triglyceride (TG), uric acid (UA), parathyroid hormone (PTH), blood phosphorus(P), fasting blood glucose (GLU), corrective calcium (Ca), calcium-phosphorus product, low-density lipoprotein (LDL-C), high-density lipoprotein (HDL-C), SO, and arterial stiffness. Results. There were 9 males and 16 females in the low PWV group and 12 males and 13 females in the high PWV group. Statistical significance was absent in patient characteristics despite more males in the high PWV group ( P = 0.055 ). The low PWV group had significantly lower mean age, SBP, SO, and PWV level, fewer diabetic patients, and higher CREA than the control group. Analysis of PWV-related factors showed that PWV was positively correlated with age, P, Ca, GLU, SBP, PTH, and SO while negatively correlated with CREA. Multiple stepwise regression analysis showed that age, SO, and SBP demonstrated great potential to predict PWV ( P < 0.05 ). Conclusion. The degree of vascular sclerosis is highly correlated with SO level in Parkinson’s disease patients, which might provide a theoretical basis for the evaluation of cardiovascular illness in Parkinson’s disease patients. High serum sclerostin level is a risk factor for deteriorated arterial stiffness. Given the limited sample size, the relevant results require further validation by expanding the sample size.

Analysis of factors influencing vascular calcification in peritoneal dialysis patients and their impact on long-term prognosis

“…2 The differences in the survival time distribution of peritoneal dialysis patients were tested using the log-rank test. There was a statistically significant difference in the overall survival time distribution between the AAC group and the Non-AAC group, with a chi-square value of 35.993 and a P-value of < 0.001 correlation between the severity of arterial stiffness and high levels of Sclerostin in PD patients, indicating that elevated serum Sclerostin levels are a risk factor for the progression of atherosclerosis [27]. In a study by Qureshi et al [28], 89 ESRD patients who underwent kidney transplantation were evaluated for the extent of vascular calcification (VC) using abdominal aortic and coronary artery calcification (CAC) scores.…”

Retracted: The Correlation between Serum Sclerostin Level and Arterial Stiffness in Peritoneal Dialysis Patients

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Peer-review manipulation …”

“…Tis article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. Tis investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”