The Correlation Between Lipid Profile and Xanthelasma

Abstract

Background: Xanthelasma is an abnormal lipid deposition on palpebrae, which is observable as yellowish plaque or nodules. Its incidence is 0.56–1.5% with onset of 15–73 years old and mostly occurs in the fourth and fifth decade. Few reports of xanthelasma did not cover the correlation between lipid profile and xanthelasma in Indonesia. Purpose: To find a correlation between lipid profile with xanthelasma in Dr. M. Djamil Hospital, Padang. Methods: This was an analytic cross-sectional study with consecutive sampling. There were 36 participants (18 xanthelasma and 18 control). Result: The highest age group was >36 - ≤45 years old (38.89%). More cases were observed in female (66.67%). Body mass index examination of xanthelasma revealed that most were overweight (55.56%). Grade I xanthelasma was the most common (72.22%). The cholesterol serum level of xanthelasma patients was higher than the subject controls (224.61±29.77 mg/dl versus­ 169.39±35.84 mg/dl) (p<0,05). The High Density Lipoprotein (HDL) serum level of xanthelasma patients was lower than controls (46.44±14.19 mg/dl versus 51.78±15.9 mg/dl) (p>0,05). The Low Density Lipoprotein (LDL) serum level of xanthelasma patients was higher than control (139.39±29.73 mg/dl versus 106.50±35.43 mg/dl) (p<0,05). Triglyceride serum level of xanthelasma patients was higher than the controls (167.83±87.26 mg/dl versus 121.61±54.52 mg/dl) (p>0,05). Conclusion: There was a correlation between higher cholesterol and LDL serum level with xanthelasma. No correlation between lower HDL and a higher triglyceride serum level with xanthelasma.

Dyslipidemia in Patients with Xanthelasma Palpebrarum Visiting the Department of Dermatology of a Tertiary Care Centre: A Descriptive Cross-sectional Study

“… 4 Published literature had shown that the group with the highest prevalence of xanthelasma was 41-50 years old (38.89%). 8 This finding was contrary to our study in which the highest number of cases (26.56%) were in the age group 46-55 years.…”

“…In a reported study, the mean ages of the patient were 47.4±9.97 years and in most patients (69%) duration of xanthelasma lesions was less than one year, 2 where as in another study the mean age of the patients was 48.61±12.36 years old and mean onset was 48.11±12.27 years. 8 In the same way, in our study the mean ages of the patients was 53.28±14.61 years and 57.81% patient with xanthelasma lesions had duration six months to one year.…”

“…12 A different study reported that the majority of patients (72.22%) suffered from multiple lesions affecting two or more eyelids. 8 A study done in India also observed that most of the patients (45.25%) had bilateral upper eyelids involvement. 14 This finding was comparable to the present study in which involvement of multiple eyelids was found to be 43.8%.…”

“…Therefore, the occurrence of xanthelasma in an individual should make health workers aware of dyslipidemia and atherosclerosis. 8 …”

“…The presence of dyslipidemia was defined as a TG of more than 150 mg/dl, TC of more than 200 mg/dl, or LDL of more than 130 mg/dl. 8 …”