The COPD Assessment Test: What Do We Know So Far?

Karloh, Manuela; Mayer, Anamaria Fleig; Silva, Rosemeri Maurici da; Pizzichini, Márcia Margaret Menezes; Jones, Paul; Pizzichini, Emílio

doi:10.1378/chest.15-1752

Cited by 115 publications

(59 citation statements)

References 31 publications

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“…In clinical practice, CAT is able to distinguish among patients with exacerbation of COPD [37], patients with different degrees of severity [37], and patients with associated comorbidities [37]. Moreover, CAT has demonstrated its validity as a prognostic measure [38,39]. In the present study, we found a close relationship between SAD and CAT (Fig.…”

Section: Discussionsupporting

confidence: 66%

Prevalence of Small-Airway Dysfunction among COPD Patients with Different GOLD Stages and Its Role in the Impact of Disease

et al. 2016

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Background: In chronic obstructive pulmonary disease (COPD) patients, small-airway dysfunction (SAD) is considered a functional hallmark of disease. However, the exact role of SAD in the clinical presentation of COPD is not yet completely understood; moreover, it is not known whether SAD may have a relationship with the impact of disease. Objectives: To evaluate the prevalence of SAD among COPD patients categorized by the old and the new GOLD classification and to ascertain whether there is a relationship between SAD and impact of disease measured by the COPD Assessment Test (CAT) questionnaire. Methods: We prospectively enrolled COPD outpatients from the University Hospital of Parma. Using the impulse oscillometry system (IOS), we assessed the fall in resistance from 5 to 20 Hz (R5-R20), reactance at 5 Hz (X5), and resonant frequency (F_Res) as markers of peripheral airway dysfunction. According to R5-R20 ≥0.07 or <0.07, the cohort was also categorized in patients with and without SAD, respectively. Results: We studied 202 patients. In both GOLD classifications, a progressive increasing distribution of R5-R20 and F_Res was reported with a decreasing of X5. Moreover, there was a significant correlation between R5-R20 and CAT (r = 0.527, p < 0.001). Finally, the presence of SAD (OR 11.96; 95% CI 4.53-31.58; p < 0.001) and use of ICS + LABA + LAMA (OR 5.31; 95% CI 1.88-15.02; p = 0.002) were independent predictors of higher impact (CAT score ≥10). Conclusion: In COPD patients, the presence of SAD, as assessed by IOS, progressively increases with GOLD classifications and it is closely related to the high impact of disease on health status.

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Section: Discussionsupporting

confidence: 66%

Prevalence of Small-Airway Dysfunction among COPD Patients with Different GOLD Stages and Its Role in the Impact of Disease

et al. 2016

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“…A mean CAT score of 15.8 in these patients, who are characterised with stable disease and a maximum of one acute exacerbation in the past 12 months, raises questions as to the clinical usefulness of the current threshold of 10 points, discriminating patients with low symptom load, as opposed to those with high symptom load. In fact, a recent meta-analysis of studies using the CAT did not support the recommended cut-off of 10 points for the purpose of assessing patient symptoms [20]. …”

Section: Discussionmentioning

confidence: 99%

Phenotypes of COPD patients with a smoking history in Central and Eastern Europe: the POPE Study

Koblížek

Milenković²,

Barczyk

et al. 2017

Eur Respir J

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Chronic obstructive pulmonary disease (COPD) represents a major health problem in Central and Eastern European (CEE) countries; however, there are no data regarding clinical phenotypes of these patients in this region.Participation in the Phenotypes of COPD in Central and Eastern Europe (POPE) study was offered to stable patients with COPD in a real-life setting. The primary aim of this study was to assess the prevalence of phenotypes according to predefined criteria. Secondary aims included analysis of differences in symptom load, comorbidities and pharmacological treatment.3362 patients with COPD were recruited in 10 CEE countries. 63% of the population were nonexacerbators, 20.4% frequent exacerbators with chronic bronchitis, 9.5% frequent exacerbators without chronic bronchitis and 6.9% were classified as asthma–COPD overlap. Differences in the distribution of phenotypes between countries were observed, with the highest heterogeneity observed in the nonexacerbator cohort and the lowest heterogeneity observed in the asthma–COPD cohort. There were statistically significant differences in symptom load, lung function, comorbidities and treatment between these phenotypes.The majority of patients with stable COPD in CEE are nonexacerbators; however, there are distinct differences in surrogates of disease severity and therapy between predefined COPD phenotypes.

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“…The COPD Assessment Test (CAT) is a disease‐special questionnaire designed to provide a simple measure of symptomatology and health status of COPD patients, validated in China . The scale consists of eight items and each question is graded from 0 to 5, giving a total score range of 0 to 40, with higher scores indicating a greater negative impact of the disease .…”

Section: Methodsmentioning

confidence: 99%

Fatigue and health‐related quality of life among patients with chronic obstructive pulmonary disease in China

Yang

Mao

et al. 2019

Clinical Respiratory J

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Objectives Fatigue is an important yet ignored symptom of chronic obstructive pulmonary disease (COPD). However, there is a paucity of literature from China on fatigue and its association with health‐related quality of life (HRQoL) among COPD patients. The purpose of this study was to (a) evaluate fatigue of COPD inpatients in China and (b) explore the association between fatigue and HRQoL. Methods This cross‐sectional study recruited patients hospitalised for an acute exacerbation of COPD within one month from three general hospitals in central China. Disease severity, fatigue and HRQoL were assessed for all participants using COPD Assessment Test (CAT), 9‐item Functional Assessment of Chronic Illness Therapy‐Fatigue scale (FACIT‐F) and 12‐Item Short‐Form Health Survey (SF‐12v2). Results A total of 210 COPD patients participated in the study between April 2017 and January 2018, with an average age of 71.1 ± 12.2 years old. The overall prevalence of moderate to severe fatigue was 48.5%. A worse FACIT‐F score was associated with worse CAT score (r = −0.74, P < 0.01; B = −0.70, P < 0.01) and worse SF‐12v2 score (r = 0.77, P < 0.01; B = 0.66, P < 0.01). Conclusion Almost half of the COPD patients experience moderate to severe fatigue. Patients with greater disease severity exhibited more severe fatigue and worse HRQoL. Fatigue symptom has a strongly negative effect on COPD patients' HRQoL, physical health and mental health. Health personnel is recommended to provide fatigue‐related screening, counselling and health education, particularly for patients with moderate to severe COPD.

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The COPD Assessment Test: What Do We Know So Far?

Cited by 115 publications

References 31 publications

Prevalence of Small-Airway Dysfunction among COPD Patients with Different GOLD Stages and Its Role in the Impact of Disease

Prevalence of Small-Airway Dysfunction among COPD Patients with Different GOLD Stages and Its Role in the Impact of Disease

Phenotypes of COPD patients with a smoking history in Central and Eastern Europe: the POPE Study

Fatigue and health‐related quality of life among patients with chronic obstructive pulmonary disease in China

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