The contribution of maternal serum markers in the early prenatal diagnosis of molar pregnancies

Jauniaux, Eric; Bersinger, NA; Gulbis, Béatrice; Meuris, Sylvain

doi:10.1093/humrep/14.3.842

Cited by 27 publications

(19 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A complete hydatidiform mole with a coexisting normal fetus was diagnosed in one of our cases and was reported earlier by our group and others [20][21][22] .…”

Section: Discussionsupporting

confidence: 81%

Adverse Outcome of Pregnancies with Extremely High Levels of Maternal Serum Human Chorionic Gonadotropin

Sharony

Itzhaky²,

Amiel³

et al. 2008

Fetal Diagn Ther

View full text Add to dashboard Cite

Background: The associated risk of elevated levels of maternal serum human chorionic gonadotropin (MShCG) with pregnancy complications was reported in many studies. However, the outcome of pregnancies with extremely high levels of MShCG was never independently studied. Methods: We report on 6 out of 45,990 studied patients with extremely high levels of MShCG (>15 multiples of the medians) analyzed during the second trimester. Results: Although our patient population was composed of more Jewish than Arab pregnant women, all those patients were Arabs. Overall, the prognosis of those pregnancies was poor. In 1 case, an antepartum fetal death occurred, 2 had premature deliveries (one of the newborns had severe failure to thrive), and 2 delivered small for gestational age babies. In 5 of these 6 cases, no specific diagnosis was established. One case was complete hydatidiform mole with a coexisting normal fetus. Conclusions: We recommend that these patients undergo counseling in which the predicted outcome will be described. In addition, a follow-up of high-risk pregnancy should be implemented: sonographic evaluation should be performed, initially to rule out a molar gestation. The patients should then be followed for growth restriction and they should be monitored to rule out other pregnancy complications such as premature labor and antepartum fetal death. Finally, the overrepresentation of Arabs among our affected patients raises the question of a possible genetic tendency for increased MShCG levels especially in the extreme level group.

show abstract

“…A complete hydatidiform mole with a coexisting normal fetus was diagnosed in one of our cases and was reported earlier by our group and others [20][21][22] .…”

Section: Discussionsupporting

confidence: 81%

Adverse Outcome of Pregnancies with Extremely High Levels of Maternal Serum Human Chorionic Gonadotropin

Sharony

Itzhaky²,

Amiel³

et al. 2008

Fetal Diagn Ther

View full text Add to dashboard Cite

show abstract

“…However, diagnosis in the first trimester is more difficult owing to the reduced extent of hydropic change, with sonographic diagnosis of CHM more likely than PHM; in the first trimester, around 80% of CHM is detectable by pre‐evacuation sonography, compared to only about 30% of PHM81–87. Before 13 weeks' gestation some PHM may appear as an enlarged placenta without or with only scanty vesicular changes88–92. Since the introduction of routine first‐trimester ultrasound examination, HMs have been evacuated at earlier gestations (current average 9–10 weeks in the UK), before the stage of development at which they have the classical morphological features, and revised diagnostic histological criteria are now required for their histopathological diagnosis93–95.…”

Section: Placental Malignancymentioning

confidence: 99%

Metal Ion Coordination to Azole Nucleosides

Müller

Böhme

Lax

et al. 2005

Chemistry A European J

View full text Add to dashboard Cite

To evaluate the possibility of introducing azole nucleosides as building blocks for metal-mediated base pairs in artificial oligonucleotides, imidazole nucleoside, 1,2,4-triazole nucleoside and tetrazole nucleoside have been synthesized and characterized. The X-ray crystal structures of p-toluoyl-protected 1,2,4-triazole and tetrazole nucleosides are reported. Contrary to the situation primarily found for deoxyribonucleosides, the sugar moieties adopt C3'-endo conformations. The acidity of the beta nucleosides increases with increasing number of nitrogen ring atoms, giving pKa values of 6.01 +/- 0.05, 1.32+/-0.05 and <-3, respectively. This decrease in basicity results in a decreasing ability to form 2:1 complexes with linearly coordinating metal ions such as Ag+ and Hg2+. In all cases, the Ag+ complexes are of higher stability than the corresponding Hg2+ complexes. Whereas imidazole nucleoside forms highly stable 2:1 complexes with both metal ions (estimated log beta2 values of >10), only Ag+ is able to reach this coordination pattern in the case of triazole nucleoside (log beta2 = 4.3 +/- 0.1). Tetrazole nucleoside does not form 2:1 complexes at all under the experimental conditions used. These data suggest that imidazole nucleoside, and to a lesser extent 1,2,4-triazole nucleoside, are likely candidates for successful incorporation as ligands in oligonucleotides based on metal-mediated base pairs. DFT calculations further corroborate this idea, providing model complexes for such base pairs with glycosidic bond distances (10.8-11.0 Angstroms) resembling those in idealized B-DNA (10.85 Angstroms).

show abstract

“…At that point it was difficult to distinguish between a spontaneous abortion and molar pregnancy. Recently, Jauniaux et al [14] reported the contribution of maternal serum markers to the early prenatal diagnosis of molar pregnancy. Based on the combination of hCG titer and ultrasonographic findings, we suspected molar pregnancy on Day 18 after the first visit.…”

Section: Resultsmentioning

confidence: 99%