2017
DOI: 10.1161/jaha.117.005729
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Abstract: BackgroundThe mechanisms underlying the possible contribution of chronic inflammation to the development of hypertension remain unclear. We examined the longitudinal association of inflammation with the progression of vascular and/or renal abnormalities in the development of hypertension.Methods and ResultsIn 3274 middle‐aged Japanese men without hypertension at the study baseline, brachial‐ankle pulse wave velocity, blood pressure, estimated glomerular filtration rate, and serum CRP (C reactive protein) level… Show more

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Cited by 62 publications
(55 citation statements)
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References 39 publications
(63 reference statements)
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“…Further studies are needed to confirm the present findings in women, in other ethnicities, and in the general population. Second, baPWV actually reflects the stiffness of the large‐ to medium‐sized arteries11, 12, 14; therefore, the importance of aortic stiffness in blood pressure elevation could not be examined precisely in this study. Third, the effect of habitual exercise, which is well known to affect the blood pressure and arterial stiffness,19 was not examined in the present study.…”
Section: Discussionmentioning
confidence: 95%
“…Further studies are needed to confirm the present findings in women, in other ethnicities, and in the general population. Second, baPWV actually reflects the stiffness of the large‐ to medium‐sized arteries11, 12, 14; therefore, the importance of aortic stiffness in blood pressure elevation could not be examined precisely in this study. Third, the effect of habitual exercise, which is well known to affect the blood pressure and arterial stiffness,19 was not examined in the present study.…”
Section: Discussionmentioning
confidence: 95%
“…End of the study period was defined by the last examination of the participants who had undergone at least 2 annual examinations. 8,9 Among the whole study subjects included, 474 (14.5%) developed hypertension (of which 152 were already receiving antihypertensive medication by the end of the study period) by the end of the study period. The mean number of times that the variables were measured was 5.2±2.1×, and the mean duration of follow-up was 6.4±2.5 years.…”
Section: Discussionmentioning
confidence: 99%
“…8,9 The cohort consisted of employees working at the headquarters of a single large Japanese construction company located in downtown Tokyo. According to the Occupational Health and Safety Law in Japan, it is mandatory for all company employees to undergo annual health checkups.…”
Section: Design and Subjectsmentioning
confidence: 99%
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