The contribution of chronic intermittent hypoxia to OSAHS: From the perspective of serum extracellular microvesicle proteins

Zhang, Huina; Yang, Fan; Guo, Yichen; Wang, Li; Fang, Fang; Wu, Hao; Nie, Shaoping; Wang, Yifan; Fung, Man-Lung; Huang, Yü; Deng, Haiteng; Qin, Yanwen; Ma, Xin‐Liang; Wei, Yongxiang

doi:10.1016/j.metabol.2018.02.012

Cited by 23 publications

(16 citation statements)

References 45 publications

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“…Many studies have reported that OSA patients express increased levels of mediators of systemic inflammatory response. Zhang et al 10 used, for the first time, a proteomic approach to detect protein profiles of serum extracellular microvescicle proteins in an intermittent hypoxia (IH) rodent model 11 . Extracellular microvescicles are vesicles released from cells into the extracellular fluid environment, including serum.…”

Section: Proteomics Approachesmentioning

confidence: 99%

“…Its pro-inflammatory and atherogenic properties have been found in endothelial cells, both smooth and striated muscle cells and macrophages. Its levels, as well as those of IL-6, are strongly associated with oxidative stress or anoxia 10 , 15 A similarly important role in the clinical picture of the OSA patient is the high level of TNF-α observed; it is, in fact, a pro-inflammatory cytokine with an important role in the host defence, which at the same time mediates the onset of a series of pathological processes including atherosclerosis, septic shock and autoimmune diseases. The release of TNF-α is mediated by IL-6, as well as by other pro-inflammatory cytokines such as IL-2, IFN-γ and by TNF-α itself through a positive feedback process 16 .…”

Section: Proteomics Approachesmentioning

confidence: 99%

See 1 more Smart Citation

A review of the “OMICS” for management of patients with obstructive sleep apnoea

Conte

Greco

Toraldo

et al. 2020

Acta Otorhinolaryngol Ital

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Section: Proteomics Approachesmentioning

confidence: 99%

Section: Proteomics Approachesmentioning

confidence: 99%

A review of the “OMICS” for management of patients with obstructive sleep apnoea

Conte

Greco

Toraldo

et al. 2020

Acta Otorhinolaryngol Ital

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show abstract

“…At present, most of the clinical analysis on GEPs are based on statistical approaches (Chen et al 2017;Zhang et al 2018;Yang et al 2018), where differentially expressed proteins are calculated using a certain fold change and p-value threshold by t-test or its variants. Unsupervised learning methods, especially hierarchical clustering, are often used for disease subtyping.…”

Section: Statistical Approaches For Gep Analysismentioning

confidence: 99%

“…Although omic data have been studied in disease diagnosis and prognosis (Zhang et al 2018;Shen et al 2020;Chen et al 2017), there remain some problems to be solved. First, existing methods mainly make predictions based on individual GEPs or their random combinations, which cannot correctly reflect the complex disease mechanism, thus yielding limited performance.…”

Section: Introductionmentioning

confidence: 99%

Multi-Level Attention Graph Neural Network for Clinically Interpretable Pathway-Level Biomarkers Discovery

Xing¹,

Yang²,

Li³

et al. 2020

Preprint

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Precision medicine, regarded as the future of healthcare, is gaining increasing attention these years. As an essential part of precision medicine, clinical omics have been successfully applied in disease diagnosis and prognosis using machine learning techniques. However, existing methods mainly make predictions based on gene-level individual features or their random combinations, none of the previous work has considered the activation of signaling pathways. Therefore, the model interpretability and accuracy are limited, and reasonable signaling pathways are yet to be discovered. In this paper, we propose a novel multi-level attention graph neural network (MLA-GNN), which applies weighted correlation network analysis (WGCNA) to format the omic data of each patient into graph-structured data, and then constructs multi-level graph features, and fuses them through a well-designed multi-level graph feature fully fusion (MGFFF) module to conduct multi-task prediction. Moreover, a novel full-gradient graph saliency mechanism is developed to make the MLA-GNN interpretable. MLA-GNN achieves state-of-the-art performance on transcriptomic data from TCGA-LGG/TCGA-GBM and proteomic data from COVID-19/non-COVID-19 patient sera. More importantly, the proposed model's decision can be interpreted in the signaling pathway level and is consistent with the clinical understanding.

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“…Previous studies have shown that inflammatory cytokines such as C reactive protein are involved, (tumor necrosis factor, TNF-α), (interleukin, IL)-6 and so on show high expression in the serum of OSAHS patients [3]. In recent years, systematic research on IL-18 and IL-6 has become more and more profound, but there is still little research on its OSAHS disease [4]. The aim of this study is to check the level of IL-18 and IL-6 in the supernatant of peripheral blood mononuclear cells (PBMCs) in serum and peripheral blood mononuclear cells of OSAHS patients and Changes of serum levels of IL-18 and IL-6 before and after treatment with Han-uvulopalatopharyngoplasty (H-UPPP), to explore the role and meaning of IL-18 and IL-6 in OSAHS pathophysiology and clinical practice [5,6].…”

Section: Introductionmentioning

confidence: 99%

The Level and Meaning of IL-18 and Other Factors in Peripheral Blood of Patients with OSAHS Under ERAS Management

Zhou¹

2018

SJPH

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Discus the management of Enhanced recovery after surgery，levels and clinical meaning of interleukin IL-18 and IL-6 in peripheral blood of patients with sleep apnea hypopnea syndrome (OSAHS). By ELISA to detect the levels of IL-18 and IL-6 in serum and peripheral blood mononuclear cells (PBMCs) supernatants of OSAHS patients and healthy controls and check the changes in serum IL-18 and IL-6 levels in OSAHS patients before and after Han uvulopalatopharyngoplasty (H-UPPP) treatment. The levels of IL-18 and IL-6 in serum and PBMCs supernatant of OSAHS patients were higher than those of the matched group (P <0.05). The levels of serum IL-18 and IL-6 increased with the severity of OSAHS, and the levels of IL-18 and IL-6 in serum and PBMCs supernatants were positively correlated (P <0.05). After 2 months of H-UPPP, the serum levels of IL-18, IL-6 and the index of respiratory disturbance were significantly lower than before the treatment (P <0. 05). The sleep quality and nocturnal hypoxia were significantly improved, and the lowest oxygen saturation was significantly higher than before the treatment (P <0.05). IL-18 and IL-6 may play an important role in the pathogenesis and prognosis of OSAHS.

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The contribution of chronic intermittent hypoxia to OSAHS: From the perspective of serum extracellular microvesicle proteins

Cited by 23 publications

References 45 publications

A review of the “OMICS” for management of patients with obstructive sleep apnoea

A review of the “OMICS” for management of patients with obstructive sleep apnoea

Multi-Level Attention Graph Neural Network for Clinically Interpretable Pathway-Level Biomarkers Discovery

The Level and Meaning of IL-18 and Other Factors in Peripheral Blood of Patients with OSAHS Under ERAS Management

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