The Content of Reticulocyte Hemoglobin and Serum Concentration of the Soluble Transferrin Receptor for Diagnostics of Anemia in Chronically Hemodialyzed Patients

Kurzawa, T.; Owczarek, Aleksander; Strzelczyk, Joanna Katarzyna; Gołąbek, Karolina; Wiczkowski, Andrzej

doi:10.17219/acem/58786

Cited by 8 publications

(6 citation statements)

References 17 publications

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“…Receiver Operating Characteristics curves revealed that the best predictor for Hb increase after six weeks of iron supplementation was an increase in week one of the intervention in reticulocyte Hb content, transferrin saturation, serum iron levels and reticulocyte count. Conversely, Kurzawa et al (2016) noted that in hemodialyzed patients with chronic renal disease the use of reticulocyte Hb content to identify anemia proved to be ineffective, with accuracy reaching only 45%. In their studies Hb, sTfR, serum iron and CRP proved to be of the most diagnostic value.…”

Section: Use Of Iron Supplements In Id and Anemiamentioning

confidence: 99%

Iron status in the elderly: A review of recent evidence

Wawer

Jennings

Fairweather‐Tait

2018

Mechanisms of Ageing and Development

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A comprehensive literature review of iron status in the elderly was undertaken in order to update a previous review (Fairweather-Tait et al, 2014); 138 summarised papers describe research on the magnitude of the problem, aetiology and age-related physiological changes that may affect iron status, novel strategies for assessing iron status with concurrent health conditions, hepcidin, lifestyle factors, iron supplements, iron status and health outcomes (bone mineral density, frailty, inflammatory bowel disease, kidney failure, cancer, cardiovascular, and neurodegenerative diseases). Each section of this review concludes with key points from the relevant papers. The overall findings were that disturbed iron metabolism plays a major role in a large number of conditions associated with old age. Correction of iron deficiency/overload may improve disease prognosis, but diagnosis of iron deficiency requires appropriate cut-offs for biomarkers of iron status in elderly men and women to be agreed. Iron deficiency (with or without anemia), anemia of inflammation, and anemia of chronic disease are all widespread in the elderly and, once identified, should be investigated further as they are often indicative of underlying disease. Management options should be reviewed and updated, and novel therapies, which show potential for treating anemia of inflammation or chronic disease, should be considered.

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Section: Use Of Iron Supplements In Id and Anemiamentioning

confidence: 99%

Iron status in the elderly: A review of recent evidence

Wawer

Jennings

Fairweather‐Tait

2018

Mechanisms of Ageing and Development

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“…For instance, in hemodialysis patients under erythropoiesis stimulating agents (ESA) therapy, different studies showed that sTfR provides a promising tool to assess bone marrow erythropoietic activity and iron status [7–9]. Recently, sTfR level has been proposed as a useful marker to diagnose iron deficiency-based anemia in chronic dialysis patients [10]. However, the lack of assay standardization and the wide variety in the cutoff values limits its interpretation in clinical practice [11].…”

Section: Introductionmentioning

confidence: 99%

“…Some factors secreted by erythroid cells along the erythropoietic process, such as growth differentiation factor 15 (GDF15) and erythroferron, have also been implicated in the suppression of hepcidin expression [17]. Erythropoiesis and inflammation are, therefore, closely linked and are both altered in dialysis patients [10,18]. The contribution for the increase in hepcidin, in these patients, is still poorly clarified and might result from the enhancement in inflammation, from the lack of renal excretion of this peptide or from other unknown factors [19,20].…”

Section: Introductionmentioning

confidence: 99%

Hepcidin and diabetes are independently related with soluble transferrin receptor levels in chronic dialysis patients

et al. 2019

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Background: Soluble transferrin receptor (sTfR) is a biomarker of erythropoiesis, which is often impaired in dialysis patients. The aim of our study was to evaluate sTfR levels in chronically dialyzed patients and assess potential determinants of its levels. Methods: We performed a cross-sectional study by evaluating 246 end-stage renal disease patients undergoing dialysis and 32 healthy controls. Circulating levels of interleukin (IL)-6, C-reactive protein (CRP), tumor necrosis factor (TNF)-α, hepcidin, sTfR, growth differentiation factor 15 (GDF15), and traditional iron metabolism markers were measured, as well as hemogram parameters. Clinical data was obtained from all patients. Results: Compared to controls, patients presented similar values of sTfR, reticulocytes and reticulocyte production index (RPI), and significantly higher levels of IL-6, CRP, ferritin, hepcidin, TNF-α, and GDF15. Iron, transferrin, hemoglobin levels, erythrocyte count, mean cell hemoglobin (MCH), and mean cell hemoglobin concentration (MCHC) values were significantly lower in dialysis group. Within patients, sTfR values were higher in diabetic patients and were positively and significantly correlated with reticulocytes and erythrocytes, RPI, and therapeutic doses of erythropoiesis stimulating agents (ESA) and intravenous iron; and inversely and significantly correlated with circulating iron, ferritin, transferrin saturation, hepcidin, MCH, and MCHC. In multiple linear regression analysis, ESA dose, RPI, serum iron, diabetes, and hepcidin levels were independently associated with sTfR levels in dialysis patients and, thus, with erythropoiesis. Conclusion: Our data suggest that, besides RPI and ESA dose, diabetes and hepcidin are closely related to erythropoiesis in dialysis patients. The influence of diabetes on sTfR levels deserves further investigation.

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“…Very likely with iron deficiency anemia. (9) This sTfR marker, in principle, checks for transferrin receptors in serum released from the cell surface of erythroblasts. When free iron in cells decreases, it will be followed by the expression of transferrin receptors on the erythroblast cell surface.…”

Section: Correlation With Inflammatory Statusmentioning

confidence: 99%

Soluble Transferrin Receptor and Soluble Transferrin Receptor/Log Ferritin Ratio are Correlated with Iron Status in Regular Hemodialysis Patients

et al. 2021

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BACKGROUND: Monitoring of iron status in chronic kidney disease patients is important, however inflammation may hinder its monitoring. Soluble transferrin receptor (sTfR) is an alternative parameter to overcome this issue, whereas ferritin play a part in the inflammation process. Hence, the correlation between the sTfR ratio and the sTfR/log ferritin ratio with conventional iron status parameters in regular hemodialysis patients is necessary to be evaluated.METHODS: A cross-sectional was conducted in the current study. As many as 5 mL of blood (2 mL for sTfR and 3 mL for serum iron and ferritin levels) was collected. sTfR level was the blood-soluble transferrin receptor level measured by the enzyme-linked immunosorbent assay (ELISA). The amount of ferritin and serum iron was determined using the immunochemiluminescent process. To evaluate the correlation, the Pearson correlation test was used.RESULTS: A total of 80 subjects was included in this study. The mean of hemoglobin was 10.25±1.66 g/dL, serum iron was 58.19±26.56 g/dL, and the median ferritin was 520.4 (49.9-3606) ng/mL. The sTfR was significantly associated only with serum iron levels with a correlation coefficient of r=-0.242; p=0.031. The sTfR/log ferritin was significantly associated with serum iron l evels (InSI)(r=-0.255, p=0.022); and transferrin saturation (r=-0.295; p=0.008).CONCLUSION: sTfR/log ferritin has a negative and significant correlation with serum iron levels and transferrin saturation, while sTfR negatively correlated with serum iron levels. sTfR and sTfR/log ferritin may be considered as an alternative iron marker in inflammation setting such as CKD.KEYWORDS: sTfR/log ferritin, iron status, serum iron, ferritin, chronic kidney disease, hemodialysis

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The Content of Reticulocyte Hemoglobin and Serum Concentration of the Soluble Transferrin Receptor for Diagnostics of Anemia in Chronically Hemodialyzed Patients

Cited by 8 publications

References 17 publications

Iron status in the elderly: A review of recent evidence

Iron status in the elderly: A review of recent evidence

Hepcidin and diabetes are independently related with soluble transferrin receptor levels in chronic dialysis patients

Soluble Transferrin Receptor and Soluble Transferrin Receptor/Log Ferritin Ratio are Correlated with Iron Status in Regular Hemodialysis Patients

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