The Consumption of Glucose During Ex Vivo Lung Perfusion Correlates With Lung Edema

Hydrogen inhalation decreases lung graft injury in brain-dead donor rats

“…Detection of glucose levels, lactic acid, pyruvate or lactate dehydrogenase in the perfusate of the donor lungs before or recipient lungs after transplantation might be more meaningful. 46,47 Third, this study has an incomplete 2-factor design, and did not observe the effects of hydrogen inhalation in grafts from non-BD donor rats. Thus, the interaction between BD and hydrogen could not be analyzed.…”

β-Adrenergic agonist infusion during extracorporeal lung perfusion: Effects on glucose concentration in the perfusion fluid and on lung function

“…24 We hypothesized a role of active sodium transport in the resolution of edema. In fact, transalveolar transport of sodium contributes to oppose the accumulation of alveolar fluid occurring after lung ischemia and reperfusion.…”

“…18 We recently showed in a pig model of EVLP that lung edema correlates with the consumption of glucose: the greater the consumption of glucose, the worse the lung edema. 24 To interpret the finding, we speculated a possible role for the active process of lung edema clearance. There is convincing evidence that the vectorial transport of salt and water across the alveolar and distal epithelium contribute to the resolution of pulmonary edema.…”

State of Art: Clinical ex vivo lung perfusion: Rationale, current status, and future directions

“…49 Glucose consumption, however, can be modulated by several variables, such as its available levels, 50 lactate concentration, 51 the presence of endothelial or epithelial injury, 52 nutritional state, 53 the presence or absence of edema, 54 and the addition of insulin to the perfusate. 55 These numerous interacting factors render the linearity and sensibility of this method questionable for the accurate evaluation of lung quality during isolated perfusion.…”