The construction and optimization of engineered yeast chassis for efficient biosynthesis of 8‐hydroxygeraniol
Yu Zhang,
Mengdi Yuan,
Xinxin Wu
et al.
Abstract:Microbial production of monoterpenoid indole alkaloids (MIAs) provides a sustainable and eco‐friendly means to obtain compounds with high pharmaceutical values. However, efficient biosynthesis of MIAs in heterologous microorganisms is hindered due to low supply of key precursors such as geraniol and its derivative 8‐hydroxygeraniol catalyzed by geraniol 8‐hydroxylase (G8H). In this study, we developed a facile evolution platform to screen strains with improved yield of geraniol by using the SCRaMbLE system emb… Show more
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