Highlights-A multidimensional approach evidence different level of inequalities distribution -Groups with diverse socioeconomic condition of accessibility to services are mapped -Spatial inequalities of a global south megacity São Paulo (Brazil) are explored -Low income groups have low accessibility mainly to hospitals and culture centers -A heterogeneous condition of accessibility and income in the periphery is captured Graphical abstract 3 LEARNING ABOUT SPATIAL INEQUALITIES: CAPTURING THE HETEROGENEITY IN THE URBAN ENVIRONMENT ABSTRACT Transportation systems can be conceptualized as an instrument of spreading people and resources over the territory, playing an important role in developing sustainable cities. The current rationale of transport provision is based on population demand, disregarding land use and socioeconomic information. To meet the challenge to promote a more equitable resource distribution, this work aims at identifying and describing patterns of urban services supply, their accessibility, and household income. By using a multidimensional approach, the spatial inequalities of a large city of the global south reveal that the low-income population has low access mainly to hospitals and cultural centers. A low-income group presents an intermediate level of accessibility to public schools and sports centers, evidencing the diverse condition of citizens in the peripheries.These complex outcomes generated by the interaction of land use and public transportation emphasize the importance of comprehensive methodological approaches to support decisions of urban projects, plans and programs. Reducing spatial inequalities, especially providing services for deprived groups, is fundamental to promote the sustainable use of resources and optimize the daily commuting.