2019
DOI: 10.1111/acel.13012
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Abstract: Whether extension of lifespan provides an extended time without health deteriorations is an important issue for human aging. However, to which degree lifespan and aspects of healthspan regulation might be linked is not well understood. Chromatin factors could be involved in linking both aging aspects, as epigenetic mechanisms bridge regulation of different biological processes. The epigenetic factor LIN-53 (RBBP4/7) associates with different chromatin-regulating complexes to safeguard cell identities in Caenor… Show more

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Cited by 13 publications
(9 citation statements)
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References 74 publications
(112 reference statements)
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“…Different extraction methods have been applied to C. elegans. Most commonly (cold) methanol, ethanol, and chloroform, either individually or in combination (in diverse rations) have been applied [29,[31][32][33][34]. For lipid extractions on the other hand, protocols from Folch and Bligh & Dyer are often used [35,36].…”
Section: Extraction Methodsmentioning
confidence: 99%
“…Different extraction methods have been applied to C. elegans. Most commonly (cold) methanol, ethanol, and chloroform, either individually or in combination (in diverse rations) have been applied [29,[31][32][33][34]. For lipid extractions on the other hand, protocols from Folch and Bligh & Dyer are often used [35,36].…”
Section: Extraction Methodsmentioning
confidence: 99%
“…Histone chaperones interact with different chromatin-regulating factors to provide gene regulatory functions with a broad spectrum of physiological functions such as cell fate safeguarding and blocking reprogramming of cell identities [2]. Recently, it was found that the histone chaperone LIN-53 in the nematode Caenorhabditis elegans (C. elegans), known as RBBP4 and RBBP7 in humans, is important for lifespan as well as healthspan regulation [3]. Interestingly, a previous study in humans revealed that RBBP4/7 are implicated in aging and age-related memory loss [4,5].…”
mentioning
confidence: 99%
“…LIN-53 links lifespan and healthspan. Loss of LIN-53 in C. elegans leads to a severe decrease in muscle function and a shortened lifespan [3]. Motility defects due to deteriorated muscle structure of lin-53 mutant animals are apparent in developing and aging animals.…”
mentioning
confidence: 99%
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