The connections of presubiculum and parasubiculum in the rat

Groen, Thomas van; Wyss, J. Michael

doi:10.1016/0006-8993(90)90976-i

Cited by 255 publications

(265 citation statements)

References 56 publications

Supporting

Mentioning

243

Contrasting

Unclassified

Order By: Relevance

“…Fibers also coursed along the alveus, consistent with direct alvear projections to the subiculum and CA1 (Amaral and Lavenex, 2007). In addition, projections also reached the presubiculum and, to a lesser extent, the parasubiculum (van Groen and Wyss, 1990). Labeling was virtually restricted to the side ipsilateral to the injection site, consistent with previous reports that the EC projection to the DG is predominantly ipsilateral (van Groen et al, 2002(van Groen et al, , 2003.…”

Section: Entorhinal Cortex Projects Ipsilaterally To the Dgsupporting

confidence: 89%

Stimulation of Entorhinal Cortex Promotes Adult Neurogenesis and Facilitates Spatial Memory

Stone

Teixeira²,

DeVito³

et al. 2011

J. Neurosci.

351

284

View full text Add to dashboard Cite

Deep brain stimulation (DBS)is an established therapeutic modality for the treatment of movement disorders and an emerging therapeutic approach for the treatment of disorders of mood and thought. For example, recently we have shown that DBS of the fornix may ameliorate cognitive decline associated with dementia. However, like other applications of DBS, the mechanisms mediating these clinical effects are unknown. As DBS modulates neurophysiological activity in targeted brain regions, DBS might influence cognitive function via activity-dependent regulation of hippocampal neurogenesis. Using stimulation parameters analogous to clinical high-frequency DBS, here we addressed this question in mice. We found that acute stimulation of the entorhinal cortex (EC) transiently promoted proliferation in the dentate gyrus (DG). Cells generated as a consequence of stimulation differentiated into neurons, survived for at least several weeks, and acquired normal dentate granule cell (DGC) morphology. Importantly, stimulation-induced promotion of neurogenesis was limited to the DG and not associated with changes in apoptotic cell death. Using immunohistochemical approaches, we found that, once sufficiently mature, these stimulation-induced neurons integrated into hippocampal circuits supporting water-maze memory. Finally, formation of water-maze memory was facilitated 6 weeks (but not 1 week) after bilateral stimulation of the EC. The delay-dependent nature of these effects matches the maturation-dependent integration of adult-generated DGCs into dentate circuits supporting water-maze memory. Furthermore, because the beneficial effects of EC stimulation were prevented by blocking neurogenesis, this suggests a causal relationship between stimulation-induced promotion of adult neurogenesis and enhanced spatial memory.

show abstract

Section: Entorhinal Cortex Projects Ipsilaterally To the Dgsupporting

confidence: 89%

Stimulation of Entorhinal Cortex Promotes Adult Neurogenesis and Facilitates Spatial Memory

Stone

Teixeira²,

DeVito³

et al. 2011

J. Neurosci.

351

284

View full text Add to dashboard Cite

show abstract

“…This nucleus receives afferents from and sends projections to the subicular region of the hippocampal formation that travels along the postcommissural fornix. 25,26 Although most in vivo studies to date have indicated that lysosomal enzymes are retrogradely transported in axons, 12,13,27 our data strongly suggests that anterograde transport of bgal is an important component of axonal distribution of this enzyme in the adult GM1-gangliosidosis brain. This notion is supported by a recent study showing identical frequency of anterograde and retrograde movement of GFP-labeled a-L-iduronidase in neurites of primary rat neurons.…”

Section: Mechanisms Of Distribution Of Mouse B-galactosidasementioning

confidence: 68%

Mechanisms of distribution of mouse β-galactosidase in the adult GM1-gangliosidosis brain

et al. 2008

View full text Add to dashboard Cite

“…In stained sections, changes in the appearance of layer II helped to identify the transitions between the presubiculum (very compact layer II), parasubiculum (broad layer II) and medial entorhinal cortex (more compact again; e.g. K ohler, 1985;van Groen & Wyss, 1990). Regional specification of deep layer cells was based on radial extension of superficial layer boundaries down through the deep layers.…”

Section: Recording Techniquesmentioning

confidence: 99%

“…Anatomically, interconnections of presubicular and parasubicular neurons with entorhinal and subicular neurons have been described (e.g. Kohler, 1985;van Groen & Wyss, 1990). Functionally, these connections have received little attention.…”

mentioning

confidence: 99%

Presubicular and Parasubicular Cortical Neurons of the Rat: Functional Separation of Deep and Superficial Neurons in Vitro

Funahashi¹,

Stewart²

1997

The Journal of Physiology

View full text Add to dashboard Cite

1. The presubiculum and parasubiculum are retrohippocampal structures bordered by the subiculum and medial entorhinal cortex. Deep layer (IV-VI) neurons from this region exhibit stable synaptically triggered burst behaviour which distinguishes them from superficial layer (I-III) cells. This functional separation was examined with intracellular and field potential recordings from horizontal slices of rat brain. Neurobiotin labelling and rapid Golgi techniques were used to obtain anatomical evidence of axonal trajectories. 2. Extracellular stimulation of the subiculum, deep medial entorhinal cortex or superficial preor parasubiculum caused, in deep layer cells only, a short latency burst discharge which could be followed by one or more after-discharges. Bursts appeared after repetitive stimulation and were stable for the life of the slice. Each event was supported by giant excitatory postsynaptic potentials (EPSPs). Events were similar whether they were evoked in horizontal slices or slices cut perpendicular to the horizontal plane. 3. Bath application of the NMDA receptor antagonist 3-[2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid (CPP; 5 ìÒ) elevated the threshold for evoking the giant EPSP. Higher concentrations (10-15 ìÒ) reduced the amplitude and duration of the giant EPSP. Bath application of the AMPA receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX; 5 ìÒ) eliminated the evoked EPSP. 4. In intact slices, superficial layer neurons of pre-and parasubiculum could exhibit EPSPs coincident with bursts recorded in the deep layers. However, in isolated subsections of horizontal slices or in 'vertical slices', both of which contained only pre-andÏor parasubiculum, evoked or picrotoxin-induced bursts occurred only in deep layer cells. Superficial layer cells in these subsections showed no response to deep layer events. 5. Antidromic population spikes confirmed projections from superficial cell layers of pre-and parasubiculum down to their deep cell layers. Reciprocal antidromic responses were absent. 6. Axons of superficial layer stellate and pyramidal cells had horizontal collaterals and at least one ascending and one descending collateral. Branches of the descending collaterals were given off in layer V and some axons were found to reach the angular bundle. Axons of deep layer stellate and pyramidal cells also had horizontal collaterals and descending collaterals which could be traced to the angular bundle. One ascending axon collateral was found among the thirty-one deep layer cells examined morphologically. 7. We conclude that the deep layer cells of the presubiculum and parasubiculum are richly interconnected with excitatory synapses. These interconnections can generate giant excitatory synaptic potentials that support the bursting behaviour exhibited by these neurons. Any of the excitatory inputs to deep layer cells can trigger the population bursts and specific inputs from entorhinal cortex produce the after-discharges. Further, connections between superficial and deep layer cells appear to b...

show abstract

The connections of presubiculum and parasubiculum in the rat

Cited by 255 publications

References 56 publications

Stimulation of Entorhinal Cortex Promotes Adult Neurogenesis and Facilitates Spatial Memory

Stimulation of Entorhinal Cortex Promotes Adult Neurogenesis and Facilitates Spatial Memory

Mechanisms of distribution of mouse β-galactosidase in the adult GM1-gangliosidosis brain

Presubicular and Parasubicular Cortical Neurons of the Rat: Functional Separation of Deep and Superficial Neurons in Vitro

Contact Info

Product

Resources

About