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Cited by 4 publications
(2 citation statements)
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“…Despite this, some ARG combinations were stably present in multiple plasmid backbones, indicating strong selection for coexistence. For example, the genes strA, strB (streptomycin resistance) and sulII (sulfonamide resistance) co-occurred in two distinct backbones (Sen1 and Kpn2, sequence overlap < 54%), likely as a signature from past co-administration of streptomycin and sulfonamides 46,47 . Similarly, while aminoglycoside resistance genes such as aadD and aac6-Aph2 were widely distributed across plasmid backbones, ant6-Ia and aph3-III were stably shared by two distinct backbones (Efa4 and Efs1, sequence overlap <11%) indicating that they may provide synergistic resistance to aminoglycosides by catalyzing different modifications.…”
Section: Diversity and Dynamics Of Arg Cassettes In The Hospital Envimentioning
confidence: 99%
“…Despite this, some ARG combinations were stably present in multiple plasmid backbones, indicating strong selection for coexistence. For example, the genes strA, strB (streptomycin resistance) and sulII (sulfonamide resistance) co-occurred in two distinct backbones (Sen1 and Kpn2, sequence overlap < 54%), likely as a signature from past co-administration of streptomycin and sulfonamides 46,47 . Similarly, while aminoglycoside resistance genes such as aadD and aac6-Aph2 were widely distributed across plasmid backbones, ant6-Ia and aph3-III were stably shared by two distinct backbones (Efa4 and Efs1, sequence overlap <11%) indicating that they may provide synergistic resistance to aminoglycosides by catalyzing different modifications.…”
Section: Diversity and Dynamics Of Arg Cassettes In The Hospital Envimentioning
confidence: 99%
“…In this background, we observed a few gene combinations that were stably present in multiple plasmid backbones, pointing to strong selection for co-existence. For example, the genes strA, strB (streptomycin resistance) and sulII (sulfonamide resistance) co-occur in two distinct backbones (Sen1 and Kpn2, sequence overlap <54%) as a signature from past co-administration of streptomycin and sulphonamides for clinical use 52,53 . Similarly, while aminoglycoside resistance genes such as aadD and aac6-Aph2 are widely and variably disseminated across plasmid backbones, the genes ant6-Ia and aph3-III are stably shared by two distinct backbones (Efa4 and Efs1, sequence overlap <11%) indicating that they may provide synergistic resistance to aminoglycosides by catalysing different modifications.…”
Section: Diversity and Dynamics Of Antibiotic Resistance Gene Cassettmentioning
confidence: 99%