The Comprehensive Approach to Preparation and Investigation of the Eu3+ Doped Hydroxyapatite/poly(L-lactide) Nanocomposites: Promising Materials for Theranostics Application

Zawisza, Katarzyna; Targońska, Sara; Gazińska, Małgorzata; Szustakiewicz, Konrad; Wiglusz, Rafał J.

doi:10.3390/nano9081146

Cited by 19 publications

(20 citation statements)

References 55 publications

(65 reference statements)

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“…PLA has been approved by the US FDA for clinical use to treat multiple medical conditions, including several orthopedic conditions ( Tyler et al, 2016 ). PLA-based composites with nanohydroxyapatite (nHAp) are highly cell-compatible and are excellent scaffolds for modulating proliferation, viability and differentiation of progenitor cells ( Smieszek et al, 2019 ; Szyszka et al, 2019 ). The use of P. purpureum in PLA matrices as a reinforcement filler offers many benefits.…”

Section: Synthetic Polymers As Scaffolds For Cartilage Tissue Engineementioning

confidence: 99%

Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering

Zhao

et al. 2021

Front. Bioeng. Biotechnol.

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Cartilage, especially articular cartilage, is a unique connective tissue consisting of chondrocytes and cartilage matrix that covers the surface of joints. It plays a critical role in maintaining joint durability and mobility by providing nearly frictionless articulation for mechanical load transmission between joints. Damage to the articular cartilage frequently results from sport-related injuries, systemic diseases, degeneration, trauma, or tumors. Failure to treat impaired cartilage may lead to osteoarthritis, affecting more than 25% of the adult population globally. Articular cartilage has a very low intrinsic self-repair capacity due to the limited proliferative ability of adult chondrocytes, lack of vascularization and innervation, slow matrix turnover, and low supply of progenitor cells. Furthermore, articular chondrocytes are encapsulated in low-nutrient, low-oxygen environment. While cartilage restoration techniques such as osteochondral transplantation, autologous chondrocyte implantation (ACI), and microfracture have been used to repair certain cartilage defects, the clinical outcomes are often mixed and undesirable. Cartilage tissue engineering (CTE) may hold promise to facilitate cartilage repair. Ideally, the prerequisites for successful CTE should include the use of effective chondrogenic factors, an ample supply of chondrogenic progenitors, and the employment of cell-friendly, biocompatible scaffold materials. Significant progress has been made on the above three fronts in past decade, which has been further facilitated by the advent of 3D bio-printing. In this review, we briefly discuss potential sources of chondrogenic progenitors. We then primarily focus on currently available chondrocyte-friendly scaffold materials, along with 3D bioprinting techniques, for their potential roles in effective CTE. It is hoped that this review will serve as a primer to bring cartilage biologists, synthetic chemists, biomechanical engineers, and 3D-bioprinting technologists together to expedite CTE process for eventual clinical applications.

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Section: Synthetic Polymers As Scaffolds For Cartilage Tissue Engineementioning

confidence: 99%

Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering

Zhao

et al. 2021

Front. Bioeng. Biotechnol.

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“…Synthetic apatites in nanometric form are extensively studied in the area of biomedical applications due to their biocompatibility, high bioactivity as well as microbiological properties in vitro [ 1 , 2 , 3 ]. Since they enhance tissue regeneration, one of their application is bone grafting and teeth fillings [ 4 ] Hydroxyapatite materials in the form of hydrogels may also be used for the acceleration of skin wound healing, e.g., in a chronic or burn wound treatment [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

New Approach to Antifungal Activity of Fluconazole Incorporated into the Porous 6-Anhydro-α-l-Galacto-β-d-Galactan Structures Modified with Nanohydroxyapatite for Chronic-Wound Treatments—In Vitro Evaluation

Rewak‐Soroczyńska

Sobierajska

Targońska

et al. 2021

IJMS

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New fluconazole-loaded, 6-anhydro-α-L-galacto-β-D-galactan hydrogels incorporated with nanohydroxyapatite were prepared and their physicochemical features (XRD, X-ray Diffraction; SEM-EDS, Scanning Electron Microscopy-Energy Dispersive X-ray Spectroscopy; ATR-FTIR, Attenuated Total Reflectance-Fourier Transform Infrared Spectroscopy), fluconazole release profiles and enzymatic degradation were determined. Antifungal activity of pure fluconazole was tested using Candida species (C. albicans, C. tropicalis, C. glabarata), Cryptococcus species (C. neoformans, C. gatti) and Rhodotorula species (R. mucilaginosa, R. rubra) reference strains and clinical isolates. Standard microdilution method was applied, and fluconazole concentrations of 2–250 µg/mL were tested. Moreover, biofilm production ability of tested isolates was tested on the polystyrene surface at 28 and 37 ± 0.5 °C and measured after crystal violet staining. Strains with the highest biofilm production ability were chosen for further analysis. Confocal microscopy photographs were taken after live/dead staining of fungal suspensions incubated with tested hydrogels (with and without fluconazole). Performed analyses confirmed that polymeric hydrogels are excellent drug carriers and, when fluconazole-loaded, they may be applied as the prevention of chronic wounds fungal infection.

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“…By analyzing the canonical transition 5 D 0 → 7 F 0 , the number of crystallographic sites substituted by europium ions into the structure of the host material can be assumed. The appearance of this transition indicates the location of Eu 3+ ions at the low-symmetry environment and its observation is enabled when Eu 3+ ions occupy sites with local symmetry of C n , C nv , C s [ 70 ]. It can be seen that in the case of transition from the level 5 D 0 to 7 F 0 for the materials that contained only one (VO 4 3 − ) group substituted for the (PO 4 3 − ) group, the band clearly stood out from the spectra of other compounds.…”

Section: Resultsmentioning

confidence: 99%

A Study of Vanadate Group Substitution into Nanosized Hydroxyapatite Doped with Eu3+ Ions as a Potential Tissue Replacement Material

Nowak

Wiglusz

2021

Nanomaterials

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In this study, nanosized vanadate-substituted hydroxyapatites doped with 1 mol% and 2 mol% Eu3+ ions were obtained via the precipitation method. To evaluate the structure and morphology of the obtained compounds, the XRPD (X-ray powder diffraction) technique, Rietveld refinement, SEM-EDS (scanning electron microscopy-energy-dispersive spectrometry) and TEM (transmission electron microscopy) techniques as well as FTIR (Fourier transform infrared) spectroscopy were performed. Moreover, the chemical formula was confirmed using the ICP-OES (Inductively coupled plasma optical emission spectroscopy spectroscopy). The calculated average grain size for powders was in the range of 25 to 90 nm. The luminescence properties of vanadium-substituted hydroxyapatite were evaluated by recording emission spectra and excitation spectra as well as luminescence kinetics. The crucial step of this research was the evaluation of the biocompatibility of the synthesized nanomaterials. Therefore, the obtained compounds were tested toward sheep red blood cells and normal human dermal fibroblast to confirm the nontoxicity and biocompatibility of new nanosized Eu3+ ion-doped vanadate-hydroxyapatite. Moreover, the final step of the research allowed us to determine the time dependent ion release to the simulated body fluid environment. The study confirmed cytocompatibility of vanadium hydroxyapatite doped with Eu3+ ions.

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The Comprehensive Approach to Preparation and Investigation of the Eu3+ Doped Hydroxyapatite/poly(L-lactide) Nanocomposites: Promising Materials for Theranostics Application

Cited by 19 publications

References 55 publications

Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering

Applications of Biocompatible Scaffold Materials in Stem Cell-Based Cartilage Tissue Engineering

New Approach to Antifungal Activity of Fluconazole Incorporated into the Porous 6-Anhydro-α-l-Galacto-β-d-Galactan Structures Modified with Nanohydroxyapatite for Chronic-Wound Treatments—In Vitro Evaluation

A Study of Vanadate Group Substitution into Nanosized Hydroxyapatite Doped with Eu3+ Ions as a Potential Tissue Replacement Material

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