2021
DOI: 10.1111/all.14555
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Abstract: The complexity of drug hypersensitivity reactionsDrug hypersensitivity reactions (DHRs) represent a global threat to healthcare systems due to their incidence, with a significant increase over last years. 1 DHR figures are overestimated in the general population since <40% of cases initially labelled as allergic can be confirmed as such when evaluated in an allergy unit. 2 Achieving an accurate diagnosis is complex and time-consuming; besides, tests must be tailored to specific clinical manifestations and unde… Show more

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Cited by 4 publications
(4 citation statements)
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“…According to the onset of symptoms, the European Network for Drug Allergy (ENDA) has categorized HSRs into two types of reactions: immediate, with symptoms onset within 1–6 h from the drug exposure, typically IgE-mediated, and non-immediate, with symptoms onset at any time, from 1 h after the initial exposure to many days after the end of the exposure. These reactions are usually delayed T cell-mediated allergic reactions [ 31 , 32 , 33 , 34 ]. It is known that platinum agents, together with their direct cytotoxic effects, also impact the immune system and can lead to immune cell activation [ 35 ].…”
Section: Discussionmentioning
confidence: 99%
“…According to the onset of symptoms, the European Network for Drug Allergy (ENDA) has categorized HSRs into two types of reactions: immediate, with symptoms onset within 1–6 h from the drug exposure, typically IgE-mediated, and non-immediate, with symptoms onset at any time, from 1 h after the initial exposure to many days after the end of the exposure. These reactions are usually delayed T cell-mediated allergic reactions [ 31 , 32 , 33 , 34 ]. It is known that platinum agents, together with their direct cytotoxic effects, also impact the immune system and can lead to immune cell activation [ 35 ].…”
Section: Discussionmentioning
confidence: 99%
“…These reactions usually arise immediately during or after the first administration of drugs, which is quite distinct from IgE-induced allergic reactions ( 6 , 24 ). It has been estimated that NADHRs make up two-thirds of immediate DHRs ( 25 , 26 ).…”
Section: Classification Of Drug Hypersensitivity Reactionsmentioning
confidence: 99%
“…These patients showed more severe systemic inflammation than DRESS and MPE 148 . Interestingly, seven miRNAs were identified as potential biomarkers that correctly identified DRESS or MPE patients 149 . The use of omics technologies, such as single‐cell RNA sequencing (scRNA‐seq), could be a promising new strategy to better understand molecular mechanisms of DHR at the single‐cell level.…”
Section: Biomarkers Of Drug Hypersensitivitymentioning
confidence: 99%
“…148 Interestingly, seven miRNAs were identified as potential biomarkers that correctly identified DRESS or MPE patients. 149 The use of omics technologies, such as single-cell RNA sequencing (scRNA-seq), could be a promising new strategy to better understand molecular mechanisms of DHR at the single-cell level. ScRNA-seq on skin and blood samples from a patient with refractory DHR/DRESS were performed and their data pointed to the JAK-STAT signaling pathway as potential target.…”
Section: Biomarkers Of Drug Hypersensitivit Ymentioning
confidence: 99%