The Complex History of the Fronto-Occipital Fasciculus

Preserving executive functions in nondominant frontal lobe glioma surgery: an intraoperative tool

“…The involvement of subcortical frontal tracts in EFs, suggested by the literature, 2,15,21,33,34 might be supported by our findings showing that the iST eloquent area is located along fibers running from the inferior frontal gyrus and medial frontal gyrus to the anterior insula, lateral to the head of the caudate nucleus and over the putamen, targeting the cingulum. Evidence correlating subcortical tract abnormalities with emotional or inhibitory control disturbances in autism suggests the involvement of frontostriatal or frontoanterior thalamic connections, possibly involving insular connectivity, in EF deficits.…”

Preserving executive functions in nondominant frontal lobe glioma surgery: an intraoperative tool

“…The involvement of subcortical frontal tracts in EFs, suggested by the literature, 2,15,21,33,34 might be supported by our findings showing that the iST eloquent area is located along fibers running from the inferior frontal gyrus and medial frontal gyrus to the anterior insula, lateral to the head of the caudate nucleus and over the putamen, targeting the cingulum. Evidence correlating subcortical tract abnormalities with emotional or inhibitory control disturbances in autism suggests the involvement of frontostriatal or frontoanterior thalamic connections, possibly involving insular connectivity, in EF deficits.…”

Fragile X–Associated Tremor/Ataxia Syndrome

“…The FXTAS-positive group indeed had significantly elevated FA compared with the older controls after adjusting for age. We also observed that another zone, from axial sections 42 to 48, had elevated FA in the FXTAS-positive group and identified superior fronto-occipital fasciculus 27,28 as the intersecting fiber tract.…”

The Papez Circuit in First-Episode, Treatment-Naive Adults with Major Depressive Disorder: Combined Atlas-Based Tract-Specific Quantification Analysis and Voxel-Based Analysis

“…In addition, other tracts implicated in MDD, such as the superior longitudinal fasciculus and the uncinate fasciculus which were significantly positively associated with depression severity [ 48 ], [ 49 ] were not confirmed in our study. Also, the cingulum in the cingulate cortex is an area that provides connectivity between the anterior cingulate and insula [ 50 ], did not appear to have lower FA in our study. We speculate that perhaps dysfunction in the Papez Circuit is essential for MDD rather than merely a component.…”

Preserving executive functions in nondominant frontal lobe glioma surgery: an intraoperative tool

“…The involvement of subcortical frontal tracts in EFs, suggested by the literature, 2,15,21,33,34 might be supported by our findings showing that the iST eloquent area is located along fibers running from the inferior frontal gyrus and medial frontal gyrus to the anterior insula, lateral to the head of the caudate nucleus and over the putamen, targeting the cingulum. Evidence correlating subcortical tract abnormalities with emotional or inhibitory control disturbances in autism suggests the involvement of frontostriatal or frontoanterior thalamic connections, possibly involving insular connectivity, in EF deficits.…”

Fragile X–Associated Tremor/Ataxia Syndrome

“…The FXTAS-positive group indeed had significantly elevated FA compared with the older controls after adjusting for age. We also observed that another zone, from axial sections 42 to 48, had elevated FA in the FXTAS-positive group and identified superior fronto-occipital fasciculus 27,28 as the intersecting fiber tract.…”

The Papez Circuit in First-Episode, Treatment-Naive Adults with Major Depressive Disorder: Combined Atlas-Based Tract-Specific Quantification Analysis and Voxel-Based Analysis

“…In addition, other tracts implicated in MDD, such as the superior longitudinal fasciculus and the uncinate fasciculus which were significantly positively associated with depression severity [ 48 ], [ 49 ] were not confirmed in our study. Also, the cingulum in the cingulate cortex is an area that provides connectivity between the anterior cingulate and insula [ 50 ], did not appear to have lower FA in our study. We speculate that perhaps dysfunction in the Papez Circuit is essential for MDD rather than merely a component.…”

Preserving executive functions in nondominant frontal lobe glioma surgery: an intraoperative tool

“…The involvement of subcortical frontal tracts in EFs, suggested by the literature, 2,15,21,33,34 might be supported by our findings showing that the iST eloquent area is located along fibers running from the inferior frontal gyrus and medial frontal gyrus to the anterior insula, lateral to the head of the caudate nucleus and over the putamen, targeting the cingulum. Evidence correlating subcortical tract abnormalities with emotional or inhibitory control disturbances in autism suggests the involvement of frontostriatal or frontoanterior thalamic connections, possibly involving insular connectivity, in EF deficits.…”

Fragile X–Associated Tremor/Ataxia Syndrome

“…The FXTAS-positive group indeed had significantly elevated FA compared with the older controls after adjusting for age. We also observed that another zone, from axial sections 42 to 48, had elevated FA in the FXTAS-positive group and identified superior fronto-occipital fasciculus 27,28 as the intersecting fiber tract.…”

The Papez Circuit in First-Episode, Treatment-Naive Adults with Major Depressive Disorder: Combined Atlas-Based Tract-Specific Quantification Analysis and Voxel-Based Analysis

“…In addition, other tracts implicated in MDD, such as the superior longitudinal fasciculus and the uncinate fasciculus which were significantly positively associated with depression severity [ 48 ], [ 49 ] were not confirmed in our study. Also, the cingulum in the cingulate cortex is an area that provides connectivity between the anterior cingulate and insula [ 50 ], did not appear to have lower FA in our study. We speculate that perhaps dysfunction in the Papez Circuit is essential for MDD rather than merely a component.…”