Infectious Disease Clinics of North America volume 25, issue 4, P851-863 2011 DOI: 10.1016/j.idc.2011.07.012 View full text
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Hemda Rosenblum, Yehuda Shoenfeld, Howard Amital

Abstract: Chronic fatigue syndrome (CFS) is characterized by unexplained fatigue that lasts for at least 6 months with a constellation of other symptoms. Most cases start suddenly, and are usually accompanied by a flu-like illness. It is a symptom-based diagnosis of exclusion, the pathogenesis of which is unknown. Studies have examined and hypothesized about the possible biomedical and epidemiologic characteristics of the disease, including genetic predisposition, infections, endocrine abnormalities, and immune dysfunct…

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