Abstract:Unbalanced or prolonged inflammation contributes to the pathogenesis of many conditions such as diabetes, arthritis, atherosclerosis and cancer to name a few. At the cellular level, macrophages of the innate immune system are central players that become inflamed in an M1‐state upon encountering pathogen, and, following clearance, shift in activation to an anti‐inflammatory (M2) state to aid in resolution of inflammation. Unfortunately, chronic diseases are promoted and exacerbated by M1‐macrophages that have b… Show more
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