The Combination of CD147 and MMP-9 Serum Levels Is Identified as Novel Chemotherapy Response Markers of Advanced Non-Small-Cell Lung Cancer

Abstract

To evaluate the correlation between the changes in serum concentrations of cluster of differentiation-147 (scCD147) and chemotherapy outcome in patients with NSCLC and evaluate the combination of scCD147 with serum matrix metalloproteinase-9 (scMMP-9) levels in the prediction of chemotherapy response, eighty-two patients with advanced LC were enrolled. Newly diagnosed cases were treated with platinum-based chemotherapy. We measured scCD147 protein levels in LC cases by ELISA and used receiver operating characteristic (ROC) curves to analyze the results. Four time points were chosen to examine the association between the changes in scCD147 and chemotherapy outcome: before chemotherapy and 21 days after the start of the first, second, and fourth chemotherapy cycles. We assessed the combination of scCD147 and scMMP-9 serum levels in predicting the chemotherapy response. scCD147 was higher in LC cases than that in healthy volunteers (HVs). scCD147 was associated with distant metastases and TNM stage. scCD147 and scMMP-9 appeared to be independent predictive factors for chemotherapy outcomes after the first and second chemotherapy cycles for patients with NSCLC. Multivariable analysis also demonstrated that variations in scCD147 and scMMP-9 could be independent factors for monitoring chemotherapy outcome for patients with NSCLC. Furthermore, when scCD147 and scMMP-9 are combined into a new risk model, it has a markedly better prediction of chemotherapy outcomes than each protein alone. scCD147 and MMP-9 are potential predictive biomarkers for efficacy, and their combination significantly improves the predictive power for chemotherapy response in patients with NSCLC.

Golgi Phosphoprotein 3 Represents a Novel Tumor Marker for Gastric and Colorectal Cancers

“…Wang et al found that combined detection of CA125 and NSE may improve diagnostic efficiency for liver metastasis of lung cancer [ 17 ]. According to Qiao et al, scCD147 and scMMP-9 could be independent factors for the prediction of chemotherapy outcome, presenting an increase in diagnostic efficiency when combined with scCD147 and scMMP-9 [ 18 ]. In our study, the results of ROC curve analysis indicated that serum GOLPH3 has a high AUC.…”

Characterizations of alveolar repair after mandibular second molar extraction: an experimental study in rats

“…The levels of EMMPRIN and MMP-9 have been identified as markers of cancer and inflammatory diseases, being critical to regulate inflammation and bone metabolism. 31 We examined the expression levels of EMMPRIN and its downstream MMP-9 to certify if they participated in alveolar ridge absorption after tooth extraction. 32 The goal of alveolar ridge site preservation is to preserve as much of the alveolar bone of the extraction wound as possible before implanting, ensuring that the implant has more bone to support it.…”

Cardiac ECM: Its Epigenetic Regulation and Role in Heart Development and Repair

“…It is up-regulated in acute coronary syndrome and heart failure, and regulates MMP expression and ECM remodeling [ 87 , 88 , 89 ]. The up-regulation of CD147 and MMPs is closely related to inflammatory processes in cancer development [ 90 , 91 ]. Resident lung progenitor cells/stem cells that differentiate into myofibroblasts lead to lung fibrosis, a complication of coronavirus disease 2019 patients (COVID-19).…”