The coexistence of psoriasis and lupus erythematosus. An analysis of 27 cases

Abstract

From 1950 through 1975, 27 patients at the Mayo Clinic, Rochester, Minn, had coexistent psoriasis and lupus erythematosus (LE). Of the 27 patients, ten had systemic LE (SLE), 13 had discoid LE, and four had drug-induced LE or an SLE-like syndrome. The onset of psoriasis preceded LE in ten patients and was concomitant with it in six. Photosensitivity was noted in 23 patients. In 20 patients, the lesions of psoriasis and LE remained clinically distinct. Morphologic overlap and clinical interaction occurred in seven patients in whom the disorders were severe and complicated by a third disease. Generally, this latter group had extensive psoriasis, prominent photosensitivity, and a poor response to therapy.

Severely Photosensitive Psoriasis: A Phenotypically Defined Patient Subset

“…We selected low-dose bbUVA in preference to a UVB source for provocation testing in this study to avoid confusion due to the elicitation of psoriasis through Ko ¨bnerization; future studies might cautiously explore the impact of UVB challenge. Ros and Wennersten (1986) reported coexistent polymorphic light eruption in 18 of 35 patients with photoaggravated psoriasis, and others reported photoaggravated psoriasis in association with chronic actinic dermatitis (Fujii et al, 2002;Sahoo and Kumar, 2002) and lupus erythematosus (Millns and Muller, 1980;Doyle, 1984). However, although features of polymorphic light eruption were witnessed in three PP patients, we found no evidence of any other coexisting photosensitivity disorder.…”

Epidemiology and comorbidities of psoriasis patients in a national database in Taiwan

“…Studies on the combination of psoriasis and systemic lupus erthematosus (SLE) have been rare, and they were mostly case reports or case series [37][38][39]. There was a higher risk of SLE in our study, especially among those with moderate to severe psoriasis.…”

Aggravation of discoid lupus erythematosus in a patient with psoriasis and psoriatic arthritis during treatment of secukinumab: A case report and review of literature

“…In a case series including 27 patients with coexistent psoriasis and LE, the onset of psoriasis preceded LE in 10 patients as with our patient. 3 High prevalence (42.0%) of PsA among patients with concomitant LE and psoriasis was observed. 5 Previous studies showed controversial results about the predictive value of anti-Ro in the coexistence of LE and psoriasis.…”